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Publikováno v:
The Journal of steroid biochemistry and molecular biology. 200
Bisphenol A(BPA) is one of the most widespread endocrine disruptors in the environment and is associated with reproductive diseases. In this study, we focused on the correlation between environmentally relevant levels of BPA exposure and histone modi
Autor:
Jürgen Geisler, Daehoon Park, Torill Sauer, Berit Gravdehaug, Marie Loeng, Nazli Bahrami, Noriko Kanaya, Shiuan Chen, Gregory Chang
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 200
The aromatase inhibitors (AIs), letrozole (Femar®/Femara®) and exemestane (Aromasin®), are widely used to treat estrogen receptor (ER) positive breast cancer in postmenopausal patients. In the setting of metastatic breast cancer, these drugs may b
Autor:
Melissa C. Smart, Maija E. Miettinen, Graham A. Hitman, Leena Moilanen, Leena Kinnunen, Juha Saltevo, Hannu Puolijoki, Jaakko Tuomilehto, Heikki Oksa, Markku Peltonen, Sirkka Keinänen-Kiukaanniemi
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 178:229-233
In addition to sunlight and dietary sources, several genes in the metabolic pathway of vitamin D affect serum 25-hydroxyvitamin D (25OHD) concentration. It is not known whether this genetic regulation is influenced by host characteristics. We investi
Autor:
Randa Salam, Hazem. El-Sayed Abou-youssef, Cristiano Rizzo, Hemmat E. El Haddad, Hany William Z. Hanna, Radwa Marawan Abdel Halim
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 212:105922
Background Hashimoto's thyroiditis (HT) is considered the predominant cause of hypothyroidism in iodine sufficient countries. The deficiency of 25−OH-vitamin D3 serum level and the variation of vitamin D receptor (VDR) gene were implicated in a num
Autor:
Sini Heinonen, Jesper Lundbom, Kirsi H. Pietiläinen, Antti Hakkarainen, Ursula Turpeinen, Jaakko Kaprio, Tomi S. Mikkola, Veera Vihma, Nina Lundbom, Esa Hämäläinen, Jussi Naukkarinen, Aila Rissanen, Matti J. Tikkanen
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 172:98-105
Obesity and ageing are associated with lower serum testosterone levels in men. How fat distribution or adipose tissue metabolism, independent of genetic factors and age, are related to sex steroid metabolism is less clear. We studied the associations
Autor:
Koen Deventer, Frederique Van de Velde, Bruno Lapauw, Peter Van Eenoo, Tim Reyns, Wim Van Gansbeke, Tom Fiers, Yves Van Nieuwenhove, Jean-Marc Kaufman, Pieter Van Renterghem
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 209:105851
Objective Men with obesity often have low total and, with increasing adiposity, also low free testosterone (T) levels, which can partially restore during weight loss. Although this is partly explained by lower sex hormone binding globulin (SHBG) prod
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 193
Innate immunity plays an important role in pathophysiology of tuberculosis which is influenced by various host factors. One such factor is vitamin D which, along with its associated molecule, can alter the host defense against Mycobacterium Tuberculo
Autor:
María V. Tschopp, María Florencia Rossetti, Cora Stoker, Luisa Gaydou, Verónica L. Bosquiazzo, Jorge G. Ramos
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 204:105767
Sex hormone synthesis occurs in various organs and tissues besides the gonads, such as adrenal glands, brain, intestines, skin, fat, bone, and cells of the immune system. Regarding the latter, it is still not clear which pathways are active, and if t
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 204:105773
Breast cancer (BC) is a major concern to female health worldwide. We assessed the circulating osteocyte-related biomarkers, hepcidin, and oxidative stress status among early-stage BC patients in aspects of clinical severity and impact on the outcome.
Autor:
Afrozul Haq, Alpana Sharma, Nidhi Gupta, Vishwajeet Singh, Raman Kumar, Vimal Kumar, Himani, Anissa Atif Mirza
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 199:105588
Multiple myeloma (MM) is a plasma cell malignancy frequently accompanied with skeletal co-morbidity. Vitamin D (1,25(OH)2D) is an important mediator of skeletal homeostasis that mediates its effect by binding to vitamin D receptor (VDR), a steroid fa