Zobrazeno 1 - 10
of 291
pro vyhledávání: ''
Autor:
Cristina Parrado-Fernandez, Paula Merino-Serrais, Silvia Maioli, Raúl Loera-Valencia, Julen Goikolea
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the complete pathogenesis of the disease is still unknown. High leve
Autor:
Alberto Benito-Martin, CheukMan C Au, Kristy A. Brown, Heta Ladumor, Sofya Oshchepkova, Ruth Moges, Priya Bhardwaj
Publikováno v:
J Steroid Biochem Mol Biol
Obesity is a risk factor for estrogen receptor-positive (ER+) breast cancer after menopause. The pro-proliferative effects of estrogens are well characterized and there is a growing body of evidence to also suggest an important role in tumorigenesis.
5-Lipoxygenase (ALOX5): Genetic susceptibility to type 2 diabetes and vitamin D effects on monocytes
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 187:52-57
The arachidonate 5-lipoxygenase (ALOX5) pathway has been implicated in chronic inflammatory disease which may be influenced by vitamin D due to vitamin D response elements (VDRE). We investigated an ALOX5 polymorphism (rs4987105) in patients with typ
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 185:7-16
Chromosome region maintenance 1 (CRM-1) and calreticulin (CALR) are two proteins that act as exportins for some nuclear receptors, in addition to other critical functions for cellular homeostasis. In several cancer types, CRM-1 and CALR are upregulat
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 185:137-141
Angiotensin 1-7 (Ang 1-7), which is a protein cleaved from angiotensin II (A-II), binds to the MAS receptor. Ang 1-7 has been demonstrated to exert protective effects against A-II-mediated cardiac, atherosclerotic, and renal damages. The aims of our
Autor:
Yoshihiro Harada, Munechika Enjoji, Nobuhiro Harada, Fumiaki Ito, Kunihisa Kobayashi, Yuriko Hamaguchi, Takafumi Yamasaki, Makito Tanabe, Toshihiko Yanase, Ichiro Abe, Kenji Ohe, Hiroki Terai, Yusuke Murata, Akila Mayeda, Masayoshi Mori, Yuta Horita, Toshiaki Utsumi, Tomoko Tanaka, Yuki Beppu, S. Miyajima, Kenji Ashida
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 182:21-26
The high-mobility group A protein 1a (HMGA1a) protein is known as an oncogene whose expression level in cancer tissue correlates with the malignant potential, and known as a component of senescence-related structures connecting it to tumor suppressor
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 209
Estrogen receptor subtype α (ERα) plays key roles in breast cancers, and has been a target for endocrine therapy for a long time. Unfortunately, long-term treatment by Aromatase Inhibitors (AIs) or Selective Estrogen Receptor Modulators (SERMs) cou
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 201
Estrogen receptor (ER)α and the human epidermal growth factor receptor (HER) family are inversely expressed in ERα-positive cancer in association with resistance to hormonal therapy, but the mechanism underlying their relationship remains unknown.
Autor:
Jürgen Geisler, Daehoon Park, Torill Sauer, Berit Gravdehaug, Marie Loeng, Nazli Bahrami, Noriko Kanaya, Shiuan Chen, Gregory Chang
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 200
The aromatase inhibitors (AIs), letrozole (Femar®/Femara®) and exemestane (Aromasin®), are widely used to treat estrogen receptor (ER) positive breast cancer in postmenopausal patients. In the setting of metastatic breast cancer, these drugs may b
Autor:
Declan P. Naughton, Hana Fakhoury, Vikentia Harizopoulou, Merve Alaylıoğlu, Spyridon N. Karras, Vasiliki Antonopoulou, Stefan Pilz, Duygu Gezen-Ak, Fatme Al Anouti, Cédric Annweiler, Kalliopi Kotsa, Dimitrios G. Goulis, Theocharis Koufakis, Pantelis Zebekakis, Erdinç Dursun
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 199
Maternal vitamin D deficiency is considered to be the key determinant of the development of neonatal vitamin D deficiency at birth and during early infancy. Specific vitamin D receptor (VDR) gene polymorphisms have been associated with adverse pregna