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Autor:
Tianhe Li, Tingting Zhang, Huanhuan Wang, Qiaoli Zhang, Huimin Gao, Ruixia Liu, Chenghong Yin
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 225
Dimethylarginine dimethylaminohydrolase 1 (DDAH1) mainly degrades asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor. Emerging evidence suggested that plasma ADMA is accumulated in patients with polycystic ovary syndrom
Autor:
Lei, Shi, Fangyan, Meng, Shaowei, Wang, Zhiyan, Hu, Jingjing, Li, Fuhong, Tian, Haixing, Wang, Yang, Zhu, Yiyan, Wang, Ren-Shan, Ge, Huitao, Li
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 225:106202
Human 3β-hydroxysteroid dehydrogenase type I (HSD3B1) and rat type IV (HSD3B4) in placentas catalyze the conversion of pregnenolone to progesterone, which plays a key role in maintaining pregnancy. Many phenolic compounds potentially inhibit HSD3B i
Autor:
Yanmin Huang, Zining Peng, Meizhen Wei, Liping Pang, Yang Cheng, Jun-An Xiao, Chunfang Gan, Jianguo Cui
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 225:106203
Straightforward access to steroidal selenocyanates in a single assembly step from steroids remains a significant challenge. However, the development of novel method for the synthesis of steroidal selenocyanates and further investigation of their bioa
Autor:
Haoxin Zhan, Silin Zhang, Lirong Li, Zikai Chen, Yi Cai, Junjun Huang, Dan Wu, Biyun Huang, Bo Wu, Xiawen Liu
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 221
Accumulation of androgens mediate alterations in prostate growth and has emerged as an essential factor in benign prostate hyperplasia (BPH). Dihydrotestosterone (DHT), the most potent natural androgen, binds to androgen receptors (AR) and regulates
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 221
The epidemiological investigation has suggested prenatal nicotine exposure (PNE) induces multiorgan developmental toxicity and increases the risk of metabolic diseases in offspring. Our previous study found that the occurrence of fetal-originated dis
Publikováno v:
Journal of Steroid Biochemistry and Molecular Biology
Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 2021, 214, pp.105996. ⟨10.1016/j.jsbmb.2021.105996⟩
Journal of Steroid Biochemistry and Molecular Biology, 2021, 214, pp.105996. ⟨10.1016/j.jsbmb.2021.105996⟩
Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 2021, 214, pp.105996. ⟨10.1016/j.jsbmb.2021.105996⟩
Journal of Steroid Biochemistry and Molecular Biology, 2021, 214, pp.105996. ⟨10.1016/j.jsbmb.2021.105996⟩
International audience; No abstract available
Autor:
Charlotte Thieffry, Marie Van Wynendaele, Lucie Samain, Donatienne Tyteca, Christophe Pierreux, Etienne Marbaix, Patrick Henriet
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology, Vol. 223, no.106153, p. 106153 (2022)
The endometrium plays a crucial role in reproduction and, in humans, is cyclically remodeled under hormonal control. Estradiol favors tissue proliferation whereas progesterone inhibits tissue growth and induces morphological changes. Endometriosis is
Autor:
Donald Poirier, Atunga Nyachieo, Andrea Romano, Jenny Roy, René Maltais, Daniel Chai, Bert Delvoux, Carla Tomassetti, Arne Vanhie
Publikováno v:
Journal of Steroid Biochemistry and Molecular Biology, 222:106136. Elsevier Science
Endometriosis is a gynecological disorder affecting about 10% of women and can lead to invalidating painful symptoms and infertility. Since there is no current definitive cure for this disease, new therapeutic options are necessary. 17β-Hydroxystero
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 218
Recent studies have highlighted the potential role of 11oxygenated (keto or hydroxy) androgens in human reproductive function with 11keto androgens circulating at concentrations comparable with testosterone in women and children. However, the intrins
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 217
In teleost, ovarian steroidogenesis governed by the neuroendocrine system is also regulated by several transcription factors of gonadal origin. Investigating the synchronized interactions between the transcriptional and the hormonal factors is vital