Zobrazeno 1 - 10
of 166
pro vyhledávání: ''
Autor:
Saki Tohyama, Charles R. Tyler, Tohru Kobayashi, Masaru Ihara, Shinichi Miyagawa, Takeshi Mizutani, Norihisa Tatarazako, Anke Lange, Yukiko Ogino, Hiroaki Tanaka, Taisen Iguchi
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 158:189-197
In vertebrates, estrogens play fundamental roles in regulating reproductive activities through estrogen receptors (ESRs), and disruption of estrogen signaling is now of global concern for both wildlife and human health. To date, ESRs of only a limite
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 158:90-103
In fishes, the expression of steroidogenic enzyme genes and their related transcription factors (TFs) are critical for the regulation of steroidogenesis and gonadal development. 11-KT is the potent androgen and hence, 11β-hsd, enzyme involved in 11-
Autor:
Nourdine Faresse
Publikováno v:
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Aldosterone or glucocorticoid stimulation of the mineralocorticoid receptor (MR) is involved in numerous physiological responses, including ions and water homeostasis, blood pressure control and metabolism. The understanding of MR signaling regulatio
Autor:
Huafeng Zou, Zhihua Jiang, Zheng Jiang, Ruqian Zhao, Yingdong Ni, Yimin Jia, Lu Qian, Xiaojing Yang
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 141:87-93
Glucocorticoid receptor (GR) is transcribed in a tissue- and cell-specific manner with multiple exon 1 mRNA variants driven by selective promoters. We recently cloned and characterized the 5.3kb proximal promoter sequence of porcine GR gene containin
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 137:57-70
Mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) are descended from an ancestral corticoid receptor (CR). To date, the earliest CR have been found in lamprey and hagfish, two jawless fish (cyclostomes) that evolved at the base of th
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 136:47-53
Novel paradigms for CYP24A1 inhibitor development are needed to circumvent existing efficacy and toxicity issues related to human therapeutics in this class. We hypothesize that improved structural knowledge of CYP24A1 in complex with natural substra
Autor:
Cindi A. Hoover, Sarah R. Greytak, Apolonia Novillo, L. Ciaccia, Kellie A. Cotter, P. Yacci, Gloria V. Callard, Ann M. Tarrant, Dima Kozakov, Sara L. Sawyer, Sandor Vajda, Gwo-Yu Chuang
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 127:176-188
Classically, the estrogen signaling system has two core components: cytochrome P450 aromatase (CYP19), the enzyme complex that catalyzes the rate limiting step in estrogen biosynthesis; and estrogen receptors (ERs), ligand activated transcription fac
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 123:91-100
Acetylation is an essential post-translational modification featuring an acetyl group that is covalently conjugated to a protein substrate. Histone acetylation was first proposed nearly half a century ago by Dr. Vincent Allfrey. Subsequent studies ha
Autor:
Baidyanath Chakrabarty, Nalini J. Gupta, Lalji Singh, Kumarasamy Thangaraj, Pooja Singh, Rajender Singh
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 122:359-363
The present study was undertaken on a case of partial androgen insensitivity syndrome to look at the etiology of the disorder. The patient exhibited a female phenotype despite 46,XY chromosome complement. Direct DNA sequencing of coding region of the
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 119:112-120
In adrenal steroidogenesis, CYP17 catalyses the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17,20-lyase reaction, yielding adrenal androgens. The enzyme exhibits distinctly different selectivities towards these substrate