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Autor:
Cristina Parrado-Fernandez, Paula Merino-Serrais, Silvia Maioli, Raúl Loera-Valencia, Julen Goikolea
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the complete pathogenesis of the disease is still unknown. High leve
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 190:198-206
Human individuals are constantly confronted to various kinds of stressors and the body's response and adaptation is essential for human health. The adrenal gland as the main producer of stress hormones plays a major role in the response to physiologi
Autor:
Rainer B. Lanz, Maria M. Szwarc, Francesco J. DeMayo, Qianxing Mo, John P. Lydon, William E. Gibbons, Lan Hai
Publikováno v:
J Steroid Biochem Mol Biol
Mouse studies support a role for endometrial early growth response 1 (EGR1) in uterine receptivity and decidualization, which are processes controlled by estrogen and progesterone. However, the importance of this transcription factor in similar cellu
Autor:
Stefan A. Wudy, David W. Walker, Ronda F. Greaves, Margaret Zacharin, Jonathan J. Hirst, Tracey A. Quinn, Emilio Badoer
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 188:77-85
DHEA and DHEAS are neuroactive neurosteroids that interact with several major receptor systems in the brain, including sigma (σ), glutamate, and GABA-A receptors. It has been recognized as early as 1952, that the loss of DHEA/DHEAS in adult life is
Autor:
Michael D. West, Hal Sternberg, Nyam Osor Chimge, Sara H Windahl, Yonatan Amzaleg, Anna E. Törnqvist, Aysha B. Khalid, Susan A. Krum, Jie Ji, Dustin E. Schones, Donlaporn Kittivanichkul, John A. Katzenellenbogen, Yankel Gabet, Baruch Frenkel, Claes Ohlsson, Elias Sabag
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 183:10-17
Estrogens attenuate bone turnover by inhibiting both osteoclasts and osteoblasts, in part through antagonizing Runx2. Apparently conflicting, stimulatory effects in osteoblast lineage cells, however, sway the balance between bone resorption and bone
Autor:
Abhishek Shetty, Padmanaban S. Suresh
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 209
Obesity increases the risk of developing cancers for both males and females. This study investigated potential crosstalk between estradiol and leptin signaling pathways within the endometrium of high-fat-diet-induced obese ovariectomized mice to gain
Autor:
Yanina Benzo, Mercedes Lasaga, Cristina Paz, Melina Andrea Dattilo, Lucía Manuela Herrera, Carla Mariana Caruso, Paula Maloberti, Paula Fernanda Lopez, Jesica Giselle Prada, Corina I. García
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 208
Acyl-CoA synthetase 4 (Acsl4), an enzyme involved in arachidonic acid (AA) metabolism, participates in physiological and pathological processes such as steroidogenesis and cancer. The role of Acsl4 in neurons and in nervous system development has als
Autor:
Davoud Jafari-Gharabaghlou, Reza Zarezadeh, Hajar Oghbaei, Amir Fattahi, Nathalie Bleisinger, Zahra Bahrami, Naser Samadi, Ralf Dittrich, Yeganeh Rastgar Rezaei, Hamid Reza Nejabati, Mohammad Nouri, Saba Nikanfar
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 209
Adipokines are mainly produced by adipose tissue; however, their expression has been reported in other organs including female reproductive tissues. Therefore, adipokines have opened new avenues of research in female fertility. In this regard, studie
Autor:
Pardis Hosseinzadeh, William Gibbons, Chellakkan S. Blesson, Jamie Merkison, Maya Barsky, Janet Bruno-Gaston, Jay Dunn, L. Yang
Publikováno v:
J Steroid Biochem Mol Biol
Polycystic ovary syndrome (PCOS) is a common form of anovulatory infertility with a strong hereditary component but no candidate genes have been found. The inheritance pattern may be due to in utero androgen programming on gene expression and mitocho
Autor:
Ying Si, Peter H. King, Siyu Zhou, Mohamed Kazamel, Tina Anderson, Yuri Kwon, Ikjae Lee, Derek Wiggins, Marcas M. Bamman, Thaddaeus Kwan
Publikováno v:
J Steroid Biochem Mol Biol
Extra-renal expression of Cytochrome P450 Family 27 Subfamily B Member 1 (CYP27B1) has been well recognized and reflects the importance of intracrine/paracrine vitamin D signaling in different tissues under physiological and pathological conditions.