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of 201
pro vyhledávání: ''
Autor:
Douglas R. Houston, Richard Lathe
Publikováno v:
Lathe, R & Houston, D 2018, ' Fatty-acylation target sequence in the ligand-binding domain of vertebrate steroid receptors demarcates evolution from estrogen-related receptors ', Journal of Steroid Biochemistry and Molecular Biology, vol. 184, pp. 20-28 . https://doi.org/10.1016/j.jsbmb.2018.07.010
Present-day nuclear receptors (NRs) responding to adrenal and sex steroids are key regulators of reproduction and growth in mammals, and are thought to have evolved from an ancestral NR most closely related to extant estrogen-related receptors (ERRs)
Autor:
Yoshihiro Harada, Munechika Enjoji, Nobuhiro Harada, Fumiaki Ito, Kunihisa Kobayashi, Yuriko Hamaguchi, Takafumi Yamasaki, Makito Tanabe, Toshihiko Yanase, Ichiro Abe, Kenji Ohe, Hiroki Terai, Yusuke Murata, Akila Mayeda, Masayoshi Mori, Yuta Horita, Toshiaki Utsumi, Tomoko Tanaka, Yuki Beppu, S. Miyajima, Kenji Ashida
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 182:21-26
The high-mobility group A protein 1a (HMGA1a) protein is known as an oncogene whose expression level in cancer tissue correlates with the malignant potential, and known as a component of senescence-related structures connecting it to tumor suppressor
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 209
Estrogen receptor subtype α (ERα) plays key roles in breast cancers, and has been a target for endocrine therapy for a long time. Unfortunately, long-term treatment by Aromatase Inhibitors (AIs) or Selective Estrogen Receptor Modulators (SERMs) cou
Autor:
Hiroyuki Okimura, T. Amami, Taisuke Mori, Akemi Koshiba, Izumi Kusuki, Yukiko Tanaka, Jo Kitawaki, S. Shigehiro, Fumitake Ito, Osamu Takaoka, Hisashi Kataoka
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 181:125-132
Endometriosis is an estrogen-dependent disease, and isoflavones interact with estrogen receptors. The purposes of this study are to investigate the in vitro and in vivo effects of daidzein-rich isoflavone aglycones (DRIAs), dietary supplements, on ce
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 202
Treatment of hormone sensitive breast cancer tumors with endocrine therapy such as antiestrogens or aromatase inhibitors has improved the outcome significantly. Studies including our own have shown that downregulation of ERα with pure antiestrogen f
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 176:31-37
Metabolic homeostasis is differentially regulated in males and females. The lower incidence of obesity and associated diseases in pre-menopausal females points towards the beneficial role of the predominant estrogen, 17β‐estradiol (E2). The action
Autor:
Rosamaria Lappano, Marcello Maggiolini
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 176:49-56
The aggressiveness of breast tumors is deeply influenced by the surrounding stroma. In this regard, the functional crosstalk between cancer cells and the tumor microenvironment has received considerable attention in recent years. Cancer-associated fi
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 176:65-72
Estrogens are potent regulators of vasomotor tone, yet underlying receptor- and ligand-specific signaling pathways remain poorly characterized. The primary physiological estrogen 17β-estradiol (E2), a non-selective agonist of classical nuclear estro
Autor:
Cristina Ripoll, Juan Martinez-Pinna, Ivan Quesada, Esther Fuentes, Manuel Castellano-Muñoz, Sergi Soriano, Paloma Alonso-Magdalena, Sabrina Villar-Pazos, Angel Nadal
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 176:16-22
Endocrine Disrupting Chemicals (EDCs), including bisphenol-A (BPA) do not act as traditional toxic chemicals inducing massive cell damage or death in an unspecific manner. EDCs can work upon binding to hormone receptors, acting as agonists, antagonis
Autor:
Lihua Li, Huitao Cheng, Fengqi Huang, Huihong Zhao, Leyun Zheng, Qing Wang, Danqi Lu, Wenbiao Niu, Chunli Zhang, Huirong Yang, Xinhe Ruan, Xuzhuo Duan, Qi He
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 212:105926
The main physiological function of 17β-estradiol (E2) in vertebrates is to regulate sexual development and reproduction. In fish, especially hermaphroditic fish, estrogen is often used to aid reproduction, but it also can trigger an inflammatory res