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Autor:
Cristina Parrado-Fernandez, Paula Merino-Serrais, Silvia Maioli, Raúl Loera-Valencia, Julen Goikolea
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the complete pathogenesis of the disease is still unknown. High leve
Autor:
Dalila Marques, Sandra K. Erickson, Hiroshi Nittono, Genta Kakiyama, Hajime Takei, Jasmohan S. Bajaj, Daniel Rodriguez-Agudo, Gregorio Gil, Phillip B. Hylemon, Michael Fuchs, Huiping Zhou, William M. Pandak
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 189:36-47
The aim of this paper was to more completely study the mitochondrial CYP27A1 initiated acidic pathway of cholesterol metabolism. The mitochondrial CYP27A1 initiated pathway of cholesterol metabolism (acidic pathway) is known to synthesize two well-de
Autor:
Alberto Benito-Martin, CheukMan C Au, Kristy A. Brown, Heta Ladumor, Sofya Oshchepkova, Ruth Moges, Priya Bhardwaj
Publikováno v:
J Steroid Biochem Mol Biol
Obesity is a risk factor for estrogen receptor-positive (ER+) breast cancer after menopause. The pro-proliferative effects of estrogens are well characterized and there is a growing body of evidence to also suggest an important role in tumorigenesis.
Autor:
Nicole Bertoletti, Aline Keils, Sandrine Marchais-Oberwinkler, Gerhard Klebe, Andreas Heine, Mohammed J. Badran
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 189:135-144
17β-Hydroxysteroid dehydrogenase type 14 (17β-HSD14) catalyzes the conversion of highly active estrogens and androgens into their less active oxidized forms in presence of NAD+ as cofactor. The crystal structure of 17β-HSD14 has been determined, h
5-Lipoxygenase (ALOX5): Genetic susceptibility to type 2 diabetes and vitamin D effects on monocytes
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 187:52-57
The arachidonate 5-lipoxygenase (ALOX5) pathway has been implicated in chronic inflammatory disease which may be influenced by vitamin D due to vitamin D response elements (VDRE). We investigated an ALOX5 polymorphism (rs4987105) in patients with typ
Autor:
L.А. Kaluzhskiy, A. V. Florinskaya, А.А. Gilep, Yu. V. Mezentsev, А.S. Ivanov, Sergei A. Usanov, Е.O. Yablokov, A.M. Tumilovich, P V Ershov
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 187:124-129
The goal of this work was to test the hypothesis that the affinity of protein-protein interactions in the cytochrome P450-dependent monooxygenase system is modulated by the low-molecular-weight compounds (substrates or inhibitors). The surface plasmo
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 186:4-21
Vitamin D, referring to the two forms, D2 from the diet and D3 primarily derived from phototransformation in the skin, is a prohormone important in human health. The most hormonally active form, 1α,25-dihydroxyvitamin D (1α,25(OH)(2)D), formed from
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 185:7-16
Chromosome region maintenance 1 (CRM-1) and calreticulin (CALR) are two proteins that act as exportins for some nuclear receptors, in addition to other critical functions for cellular homeostasis. In several cancer types, CRM-1 and CALR are upregulat
Autor:
Carsten Carlberg, Antonio Neme
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 185:103-109
The vitamin D-modulated transcriptome of highly responsive human cells, such as THP-1 monocytes, comprises more than 500 genes, half of which are primary targets. Recently, we proposed a chromatin model of vitamin D signaling demonstrating that nearl
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 185:137-141
Angiotensin 1-7 (Ang 1-7), which is a protein cleaved from angiotensin II (A-II), binds to the MAS receptor. Ang 1-7 has been demonstrated to exert protective effects against A-II-mediated cardiac, atherosclerotic, and renal damages. The aims of our