Zobrazeno 1 - 10
of 25
pro vyhledávání: ''
Autor:
Xi Chu, Fan Yang, Yuanyuan Zhang, Nan Zhang, Yongsheng Dong, Hui Guo, Ling Liu, Jianping Zhang, Zhenyi Liu, Yifan Bao, Xuan Zhang
Publikováno v:
The Journal of pharmacy and pharmacology. 68(4)
Objectives This study investigated the effect of tannic acid (TA), a plant-derived hydrolyzable polyphenol, on Kv7.4 and Kv7.5 K+ channels and rat mesenteric artery. Methods Whole-cell patch clamp experiments were used to record the Kv7.4 and Kv7.3/7
Antispasmodic activity of licochalcone A, a species-specific ingredient of Glycyrrhiza inflata roots
Publikováno v:
The Journal of pharmacy and pharmacology. 59(10)
Licochalcone A, a species-specific and characteristic retrochalcone ingredient of Glycyrrhiza inflata root, has been shown to possess multiple bioactive properties. However, its muscle relaxant activity has not been reported previously. Licochalcone
Publikováno v:
The Journal of pharmacy and pharmacology. 58(7)
We have investigated the relationship between structure and antioxidative activity of piperidine nitroxides which were substituted by different groups at the 4-position. All of the tested piperidine nitroxides inhibited malondialdehyde (MDA) generati
Autor:
Gabino Garrido, Lucía Márquez Montiel, Alina Álvarez León, Ivones Hernández Balmaseda, René Delgado Hernández, Belkis Cancio Hernández, Salvatore Cuzzocrea, Dagmar García Rivera
Publikováno v:
The Journal of pharmacy and pharmacology. 58(3)
Vimang is the brand name of formulations containing an extract of Mangifera indica L., ethnopharmacologically used in Cuba for the treatment of some immunopathological disorders, including bronchial asthma, atopic dermatitis and other allergic diseas
Autor:
Wilfried Dimpfel
Publikováno v:
The Journal of pharmacy and pharmacology. 58(3)
This study investigated the possibility that hesperidin or hesperetin might interact directly with brain matter in a physiological manner. The effects of both compounds were followed in the in-vitro hippocampus preparation by continuous superfusion i
Autor:
Meng-Ling Wang, Wei-Ping Zhang, Zhong Chen, Er-Qing Wei, Lu-ying Liu, Fang-Xue Chen, Yan-Min Zhao
Publikováno v:
The Journal of pharmacy and pharmacology. 57(8)
Baicalin is a flavonoid derivative from Scutellaria baicalensis Georgi with various pharmacological effects. Recently, the neuroprotective effect of baicalin was reported. To confirm this effect and explore the possible mechanism, we have investigate
Publikováno v:
The Journal of pharmacy and pharmacology. 57(6)
Using a cyanide model to induce neurotoxic effects in rat brain homogenates, we examined the neuroprotective properties of three H3 antagonists, namely clobenpropit, thioperamide and impentamine, and compared them to aspirin, a known neuroprotective
Autor:
Masakazu Yamaguchi, Kenji Nishioka, Masataka Saito, Osamu Shibata, Tetsuji Makita, Koji Sumikawa, Maki Yoshimura
Publikováno v:
The Journal of pharmacy and pharmacology. 56(7)
Selegiline is widely used for Parkinson's disease and sometimes for Alzheimer's disease. It is reported to affect intracellular Ca2+ concentration. Since intracellular Ca2+ is partly regulated by phosphatidylinositol (PI) response and is important fo
Autor:
Eun Sook Yoo, Ho Jung Son, Joon Seok Park, Ae Ra Kim, Kyong Up Baik, Myung Hwan Park, Jae Youl Cho
Publikováno v:
The Journal of pharmacy and pharmacology. 56(4)
Dialkoxyphenyl compounds have been reported to possess anti-inflammatory activity through inhibition of phosphodieseterase (PDE) type IV. In this study, a series of derivatives of dialkoxyphenyl compounds with an oxime group, which is generally known
Publikováno v:
The Journal of pharmacy and pharmacology. 54(11)
Progesterone induced rapid relaxation of KCl-induced contraction of rat aortic rings. The relaxant effect of progesterone on aortic rings was concentration-dependent (over the range of 10−10 to 10−5M) and partially dependent on the endothelium. A