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Autor:
Chunxiao Ye, Qing Ding, Xia Zhan, Bin Lv, Jun Peng, Xixiao Yang, Shulong Wu, Tianrong Xun, Congyan Chen, Bin Liu, Liqian Mo, Xiaokang Wang
Publikováno v:
The Journal of pharmacy and pharmacology. 73(8)
Objectives The aim of the study was to explore the effect of total glucosides of paeony (TGP) and Tripterygium wilfordii polyglycosides (TWP) on erythrocyte methotrexate polyglutamates (MTXPGs), the metabolites of methotrexate (MTX). Methods An ultra
Autor:
Jongbong Park, Bombi Lee, Insop Shim, Hyejung Lee, Sang Muk Oh, Mi Jung Yeom, Sunoh Kwon, Dae Hyun Hahm, Moo Won Park
Publikováno v:
The Journal of pharmacy and pharmacology. 62(2)
Objectives The ameliorating effects of wild ginseng on learning and memory deficits were investigated in rats. Methods Rats were treated daily with wild ginseng or cultivated ginseng for 7 days at 30 min before scopolamine injection (2 mg/kg, i.p.).
Publikováno v:
The Journal of pharmacy and pharmacology. 60(10)
This study investigated the effect of pioglitazone on the pharmacokinetics of oral and i.v. nicardipine in rats. Pharmacokinetic parameters were determined after nicardipine was administered orally (12 mg kg−1) or i.v. (4 mg kg−1) with or without
Publikováno v:
The Journal of pharmacy and pharmacology. 60(1)
The aim of this study was to investigate the transdermal iontophoretic delivery of methotrexate, alone or in combination with microneedles, in-vitro and in-vivo using intracutaneous microdialysis in the hairless rat. The average depth of the microdia
Publikováno v:
The Journal of pharmacy and pharmacology. 60(1)
The types of hepatic cytochrome P450 (CYP) isozymes responsible for the metabolism of theophylline and for the formation of 1,3-dimethyluric acid (1,3-DMU) in rats in-vivo does not seem to have been studied at the dose ranges of dose-independent meta
Autor:
Mehrdad Hamidi
Publikováno v:
The Journal of pharmacy and pharmacology. 59(8)
The central nervous system (CNS) distribution kinetics of indinavir were extensively evaluated using a combinational in-vivo model comprising the integration plot method (a single-passage approach) and neuropharmacokinetic method (a multiple-passage
Publikováno v:
The Journal of pharmacy and pharmacology. 57(12)
Sulfasalazine is characterised by low oral bioavailability. In this study, its intestinal transport characteristics were studied in an in-vitro, ex-vivo and in-situ system. The absorptive transport of sulfasalazine across Caco-2 monolayers appeared t
Autor:
Lenka Skálová, Barbora Szotáková, Bohumila Suchanova, Vladimír Wsól, Marek Link, Romana Novotná
Publikováno v:
The Journal of pharmacy and pharmacology. 57(3)
Sibutramine is an anti-obesity drug sold as a racemic mixture under the trademark Meridia or Reductil. With the aim of evaluating the stereoselectivity in phase I of sibutramine biotransformation, the formation of the main metabolites from R-sibutram
Publikováno v:
The Journal of pharmacy and pharmacology. 56(8)
Grapefruit juice can modify the pharmacokinetic parameters of many drugs, in particular simvastatin, an orally active cholesterol-lowering agent. The exact components in grapefruit juice responsible for drug interactions are not perfectly known. Howe
Publikováno v:
The Journal of pharmacy and pharmacology. 56(6)
We evaluated the role of specific isoforms in the biotransformation of phenacetin and chlorzoxazone and examined the effect of age on these reactions using liver microsomes from Fischer 344 rats between 3 and 26 months of age. Using rat cDNA-expresse