Zobrazeno 1 - 10
of 212
pro vyhledávání: ''
Autor:
Chunxiao Ye, Qing Ding, Xia Zhan, Bin Lv, Jun Peng, Xixiao Yang, Shulong Wu, Tianrong Xun, Congyan Chen, Bin Liu, Liqian Mo, Xiaokang Wang
Publikováno v:
The Journal of pharmacy and pharmacology. 73(8)
Objectives The aim of the study was to explore the effect of total glucosides of paeony (TGP) and Tripterygium wilfordii polyglycosides (TWP) on erythrocyte methotrexate polyglutamates (MTXPGs), the metabolites of methotrexate (MTX). Methods An ultra
Autor:
Kazuhiko Arimori, Keishi Yamasaki, Muneaki Hidaka, Yumiko Furuya, Hiroshige Ono, Yohei Kawano
Publikováno v:
The Journal of pharmacy and pharmacology. 73(2)
Objectives Irinotecan is a widely intravenously used drug for the treatment of certain types of solid tumours. The oral administration of irinotecan has recently been recognized as being a more effective method for the treatment than intravenous admi
Autor:
Layany Carolyny Mourão Mulvaney, Vera Lúcia Garcia, Alice M. S. Rodrigues, Francisco Humberto Xavier-Júnior, Didier Stien, Silmara Marques Allegretti
Publikováno v:
Journal of Pharmacy and Pharmacology
Journal of Pharmacy and Pharmacology, Royal Pharmaceutical Society of Great Britain, 2021, 73, pp.377-387. ⟨10.1093/jpp/rgaa030⟩
Journal of Pharmacy and Pharmacology, Royal Pharmaceutical Society of Great Britain, 2021, 73, pp.377-387. ⟨10.1093/jpp/rgaa030⟩
Objectives To evaluate the antibacterial, antifungal and anthelmintic activities of the ethanolic extract (EEMz), fractions (LPFMz and HPFMz) and compounds isolated from the leaves of Manilkara zapota L. P. Royen. Methods Extract and fractions were p
Autor:
Mahsa Kaveh, Nama Mohammadian Roshan, Farzaneh Shakeri, Mohammad Hossein Boskabady, Ramin Rezaee
Publikováno v:
The Journal of pharmacy and pharmacology. 71(7)
Objectives Effect of alpha-linolenic acid (ALA) against ovalbumin (OVA)-induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat. Methods Total and differential WBC count and oxidant/antioxidant levels in BALF
Publikováno v:
The Journal of pharmacy and pharmacology. 71(7)
Objectives Antidepressants need to penetrate the blood–brain barrier (BBB) to exert their functions in the central nervous system. Breast cancer resistance protein (BCRP), an efflux transporter abundantly expressed in the BBB, prevents the accumula
Publikováno v:
The Journal of pharmacy and pharmacology. 71(5)
Objectives To investigate the effects of multiple doses of baicalin (BG) on the pharmacokinetics of ciclosporin (CsA) in rats and the potential mechanisms. Methods Pharmacokinetic parameters of CsA were determined in male rats after administration of
Autor:
Amel Bouzabata, Mohamed L. Ashour, Mansour Sobeh, Riham M. Abu-Zeid, Fadia S. Youssef, Michael Wink, Haidy A. Gad, Mahmoud Zaki El-Readi
Publikováno v:
The Journal of pharmacy and pharmacology. 70(7)
Objectives To explore the potential anti-inflammatory activity of Bupleurum marginatum extracts using in vitro and in vivo studies supported by virtual screening. Methods Antioxidant activity was assessed using the DPPH˙ and inhibition of 2-deoxyrib
Autor:
Glauce Socorro de Barros Viana, Edilberto R. Silveira, Roberta de Oliveira Costa, Luzia Kalyne Almeida Moreira Leal, Alan Diego da Conceição Santos, Kelly Rose Tavares Neves, Patrícia Coelho do Nascimento Nogueira, Jalles Dantas de Lucena, Dayane Pessoa de Araújo, Carlos Vinicius Jataí Gadelha-Filho, Francisco Arnaldo Viana Lima
Publikováno v:
The Journal of pharmacy and pharmacology. 70(6)
Objectives Aspidosperma species are used for several diseases, especially for malaria in Brazil. Although the genus is object of pharmacological studies, almost none are found on Aspidosperma pyrifolium. We investigate neuroprotective, antioxidant an
Autor:
Nastaran Rahimi, Ahmad Reza Dehpour, Shahram Ejtemaei Mehr, Ali Reza Abdollahi, Tahmineh Mokhtari, Fatemeh Yarmohammadi, Hedyeh Faghir-Ghanesefat
Publikováno v:
The Journal of pharmacy and pharmacology. 69(12)
Objectives Alpha7 nicotinic acetylcholine receptor (α7-nAChR), an emerging pharmacological target for a variety of medical conditions, is expressed in the most mammalian tissues with different effects. So, this study was designed to investigate the
Autor:
Mohamed L. Ashour, Michael Wink, Fadia S. Youssef, Abdel Nasser B. Singab, Sherif S. Ebada, Hesham A. El-Beshbishy, Mansour Sobeh
Publikováno v:
The Journal of pharmacy and pharmacology. 69(6)
Objectives This study was designed to evaluate the antihyperglycaemic activity of the methanol leaf extract of Eremophila maculata (EMM) both in vitro and in vivo. Methods The antihyperglycaemic activity was assessed in vitro using differentiated 3T3