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Autor:
Sandra E. Juul
Publikováno v:
The Journal of Pediatrics. 143:321-326
Human fetuses and neonates ingest erythropoietin (Epo) when they swallow amniotic fluid, colostrum, and human milk. This study was designed to determine whether enterally dosed recombinant Epo (rEpo) stimulates erythropoiesis in preterm neonates.Pret
Autor:
Paul Scigalla, B L Salle, Christian P. Speer, Rolf F. Maier, Martin Wagner, G. Moriette, Bianca M. Regazzoni, E. Kattner, Jürgen Natzschka, Peter Groneck, Gaston J E Verellen, E Ludwig Grauel, Michael Obladen, Jean Messer, Vineta Fellman
Publikováno v:
The Journal of Pediatrics. 132:866-870
Objective: To investigate whether a weekly 1500 IU/kg dose of recombinant human erythropoietin (rhEPO) is more effective than a dose of 750 IU/kg/week in preventing anemia and reducing the transfusion need in infants with birth weights less than 1000
Publikováno v:
The Journal of Pediatrics. 129:258-263
To determine whether intravenously administered iron supplements would improve the hematologic response to recombinant erythropoietin in stable preterm infants.Forty-two preterm infants (33 weeks' gestation, birth weight1500 gm, hematocrit38%) were t
Publikováno v:
The Journal of Pediatrics. 125:117-122
To compare the efficacy of dopamine and dobutamine for the treatment of hypotension (mean arterial blood pressure,or = 30 mm Hg) in preterm (or = 34 weeks of gestation) infants with respiratory distress syndrome in the first 24 hours of life, we enro
Publikováno v:
The Journal of Pediatrics. 124:215-219
The objectives of this study were to quantify the amount of blood required to suppress synthesis of hemoglobin S (HbS) in patients with hemoglobin SS on a long-term transfusion regimen and to evaluate factors that might contribute to variations in tr
Publikováno v:
The Journal of pediatrics. 160(5)
Objective To compare reticulocyte responses of once-per-week erythropoietin (EPO) dosing with 3-times-a-week dosing in preterm infants. Study design Infants weighing ≤1500 g and ≥7 days of age were randomized to once-per-week EPO, 1200 U/kg/dose,
Publikováno v:
The Journal of Pediatrics. 123:996-1000
Because anemia in patients with bronchopulmonary dysplasia is characterized by inappropriately low serum concentrations of erythropoietin but increased in vitro sensitivity of erythroid progenitors to erythropoietin, we speculated that administration
Publikováno v:
The Journal of Pediatrics. 121:98-102
To determine whether prophylactic treatment with recombinant human erythropoietin (rHuEPO) and iron would reduce the need for blood transfusions, we randomly assigned 22 premature infants with gestational ages less than or equal to 32 weeks and birth
Autor:
Kevin Shannon, Robert I. Abels, Sharon Decelle, Roderic H. Phibbs, Marcia Wertz, Wen Yi Li, Dorothy Thompson, Jodie Thayer-Moriyama, William C. Mentzer
Publikováno v:
The Journal of Pediatrics. 120:586-592
We randomly assigned eight concurrently symptom-free premature infants (birth weight less than or equal to 1250 gm) at high risk of requiring erythrocyte transfusions for anemia of prematurity to 6 weeks of intensive treatment with either subcutaneou
Autor:
Nancy Newton, Kevin Shannon, Susan Sniderman, Roderic H. Phibbs, Roberta A. Ballard, Robert I. Abels, Patricia Freeman, William C. Mentzer, Dorothy Thompson
Publikováno v:
The Journal of Pediatrics. 118:949-955
Experimental and clinical data implicate inadequate erythropoietin production as an important reason that infants acquire this anemia and suggest that recombinant human erythropoietin (r-HuEPO) might be used to treat or prevent it. We therefore rando