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Autor:
Sandra E. Juul
Publikováno v:
The Journal of Pediatrics. 143:321-326
Human fetuses and neonates ingest erythropoietin (Epo) when they swallow amniotic fluid, colostrum, and human milk. This study was designed to determine whether enterally dosed recombinant Epo (rEpo) stimulates erythropoiesis in preterm neonates.Pret
Publikováno v:
The Journal of Pediatrics. 129:258-263
To determine whether intravenously administered iron supplements would improve the hematologic response to recombinant erythropoietin in stable preterm infants.Forty-two preterm infants (33 weeks' gestation, birth weight1500 gm, hematocrit38%) were t
Publikováno v:
The Journal of Pediatrics. 123:996-1000
Because anemia in patients with bronchopulmonary dysplasia is characterized by inappropriately low serum concentrations of erythropoietin but increased in vitro sensitivity of erythroid progenitors to erythropoietin, we speculated that administration
Publikováno v:
The Journal of Pediatrics. 121:98-102
To determine whether prophylactic treatment with recombinant human erythropoietin (rHuEPO) and iron would reduce the need for blood transfusions, we randomly assigned 22 premature infants with gestational ages less than or equal to 32 weeks and birth
Autor:
Kevin Shannon, Robert I. Abels, Sharon Decelle, Roderic H. Phibbs, Marcia Wertz, Wen Yi Li, Dorothy Thompson, Jodie Thayer-Moriyama, William C. Mentzer
Publikováno v:
The Journal of Pediatrics. 120:586-592
We randomly assigned eight concurrently symptom-free premature infants (birth weight less than or equal to 1250 gm) at high risk of requiring erythrocyte transfusions for anemia of prematurity to 6 weeks of intensive treatment with either subcutaneou
Autor:
Nancy Newton, Kevin Shannon, Susan Sniderman, Roderic H. Phibbs, Roberta A. Ballard, Robert I. Abels, Patricia Freeman, William C. Mentzer, Dorothy Thompson
Publikováno v:
The Journal of Pediatrics. 118:949-955
Experimental and clinical data implicate inadequate erythropoietin production as an important reason that infants acquire this anemia and suggest that recombinant human erythropoietin (r-HuEPO) might be used to treat or prevent it. We therefore rando
Autor:
Jean-Claude Fauchère, Brigitte M. Koller, Alois Tschopp, Christof Dame, Christoph Ruegger, Hans Ulrich Bucher, Georg Zeilinger, Sylviane Pasquier, Christoph Bührer, René Glanzmann, Sven Schulzke, Brigitte Scharrer, Walter Bär, Riccardo Pfister, Krämer Karin, Brigitte Koller, Sven Wellmann
Publikováno v:
The Journal of Pediatrics, Vol. 167, No 1 (2015) pp. 52-57.e3
Objective To investigate the safety and short term outcome of high dose recombinant human erythropoietin (rhEpo) given shortly after birth and subsequently over the first 2 days for neuroprotection to very preterm infants. Study design Randomized, do
Publikováno v:
The Journal of pediatrics. 142(3)
Objective Zinc protoporphyrin/heme ratio (ZnPP/H) has been well established as an indicator of functional iron deficiency in subjects 6 months of age to adult. The primary objective of this study was to establish normative values for ZnPP/H in NICU p
Autor:
Dimitrios Tsakiris, Chaido Tsantali, Vassiliki Soubasi, Elissavet Diamanti, Kosmas Sarafidis, George Kremenopoulos
Publikováno v:
The Journal of pediatrics. 127(2)
Treatment with recombinant human erythropoietin (rHuEPO) stimulates erythropoiesis and reduces the need for transfusions in hospitalized preterm infants. The aim of our study was to follow very low birth weight infants after the initial 6 weeks of rH
Effects of recombinant human erythropoietin in infants with the anemia of prematurity: a pilot study
Autor:
Jean-François Babel, Daniel S. Halperin, Gerald Lacourt, Martine Félix, Marinette Wyss, Matti Aapro, Pierre Wacker
Publikováno v:
The Journal of pediatrics. 116(5)
In an attempt to stimulate endogenous erythrocyte production and thereby provide an alternative to erythrocyte transfusions, we administered recombinant human erythropoietin (rHuEpo) in doses of 75 to 300 units/kg/wk to seven infants with the anemia