Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Charles Swanton"'
Publikováno v:
The Journal of Pathology. 232:264-273
Despite advances in the diagnosis and treatment of cancer, the majority of advanced metastatic solid tumours remain incurable. Differential gene expression, somatic mutational status, tumour-specific genetic signatures and micro-environmental selecti
Autor:
Nicholas McGranahan, James Larkin, Sergio A. Quezada, Karl S. Peggs, Andrew Furness, Marco Gerlinger, Charles Swanton, Teresa Marafioti, Vishvesh H. Shende, Rosalie Fisher, Andrew Rowan, David Nicol, Lisa Pickering, Martin Gore, Steven Hazell, Harlan Robins, David Hamm
Publikováno v:
The Journal of Pathology
The recognition of cancer cells by T cells can impact upon prognosis and be exploited for immunotherapeutic approaches. This recognition depends on the specific interaction between antigens displayed on the surface of cancer cells and the T cell rece
Autor:
Adriana C. Flora, Richard Marais, Dominique Stoppa-Lyonnet, Roger A'Hern, Alan Mackay, Iwanka Kozarewa, Vidya Pawar, Alan Ashworth, Christopher J. Lord, Odette Mariani, Petra van der Groep, Marc-Henri Stern, Andrew R. Green, Simon J. Furney, William D. Foulkes, Rachael Natrajan, Jason S. Carroll, Simon S. McDade, Elodie Manié, Patty Wai, Maryou B. Lambros, Charles Swanton, Paul J. van Diest, Anne Vincent-Salomon, Britta Weigelt, Jorge S. Reis-Filho, Ian O. Ellis, Tatiana Popova, Samra Turajlic, Anita Grigoriadis, Olivier Delattre, Daniel Nava Rodruigues, Paul M. Wilkerson
Publikováno v:
The Journal of Pathology. 227:29-41
BRCA1 encodes a tumour suppressor protein that plays pivotal roles in homologous recombination (HR) DNA repair, cell-cycle checkpoints, and transcriptional regulation. BRCA1 germline mutations confer a high risk of early-onset breast and ovarian canc
Autor:
Philip East, Rebecca Roylance, Charles Swanton, Lina M. Obeid, Sharon A. Tooze, Neil P. Jones, Stefka D. Spassieva, Julian Downward, Andrew M. Hanby, Valerie Speirs, Andrew Rowan, Patricia Gorman, Alvin J.X. Lee, Barbara Nicke, Zoltan Szallasi, Nicolai Juul Birkbak, Nicole C. McKnight, Jil Sander, Maik Kschischo, David Endesfelder
Publikováno v:
Lee, A J X, Roylance, R, Sander, J, Gorman, P, Endesfelder, D, Kschischo, M, Jones, N P, East, P, Nicke, B, Spassieva, S, Obeid, L M, Birkbak, N J, Szallasi, Z, McKnight, N C, Rowan, A J, Speirs, V, Hanby, A M, Downward, J, Tooze, S A & Swanton, C 2012, ' CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction ', Journal of Pathology, vol. 226, no. 3, pp. 482-494 . https://doi.org/10.1002/path.2998
Chromosomal instability (CIN) has been implicated in multidrug resistance and the silencing of the ceramide transporter, CERT, promotes sensitization to diverse cytotoxics. An improved understanding of mechanisms governing multidrug sensitization mig
Publikováno v:
The Journal of pathology. 232(2)
Despite advances in the diagnosis and treatment of cancer, the majority of advanced metastatic solid tumours remain incurable. Differential gene expression, somatic mutational status, tumour-specific genetic signatures and micro-environmental selecti
Autor:
Rebecca A. Burrell, Andrew Rowan, James Larkin, Pierre Martinez, Tejal Joshi, Charles Swanton, Zoltan Szallasi, Nicolai Juul Birkbak, Rosalie Fisher, Marco Gerlinger, Nicholas McGranahan
Publikováno v:
Martinez, P, Birkbak, N J, Gerlinger, M, McGranahan, N, Burrell, R, Rowan, A, Joshi, T, Fisher, R, Larkin, J, Szallasi, Z I & Swanton, C 2013, ' Parallel evolution of tumor subclones mimics diversity between tumors ', Journal of Pathology, vol. 230, no. 4, pp. 356-364 . https://doi.org/10.1002/path.4214
Intratumour heterogeneity (ITH) may foster tumour adaptation and compromise the efficacy of personalized medicine approaches. The scale of heterogeneity within a tumour (intratumour heterogeneity) relative to genetic differences between tumours (inte
Autor:
Liwen, Lu, Vitor H, Teixeira, ZhengQiang, Yuan, Trevor A, Graham, David, Endesfelder, Krishna, Kolluri, Noura, Al-Juffali, Nicholas, Hamilton, Andrew G, Nicholson, Mary, Falzon, Maik, Kschischo, Charles, Swanton, Nicholas A, Wright, Bernadette, Carroll, Fiona M, Watt, Jeremy P, George, Kim B, Jensen, Adam, Giangreco, Sam M, Janes
Publikováno v:
The Journal of Pathology
Epidermal growth factor receptor (EGFR) pathway activation is a frequent event in human carcinomas. Mutations in EGFR itself are, however, rare, and the mechanisms regulating EGFR activation remain elusive. Leucine-rich immunoglobulin repeats-1 (LRIG