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Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(17)
Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotransmission in brain regions, such as the amygdala and hippocampus, which are relevant to seizures and epilepsy. Here we used 2-amino-3-(3-hydroxy-5-tert
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(3)
Intranigral injection of the transient receptor potential vanilloid subtype 1 (TRPV1; also known as VR1) agonist capsaicin (CAP) into the rat brain, or treatment of rat mesencephalic cultures with CAP, resulted in cell death of dopaminergic (DA) neur
Autor:
Matthew D. Kohls, Priyattam J. Shiromani, Thomas S. Kilduff, Douglas A. Lappi, Rafael J. Salín-Pascual, Nahid Waleh, MaryAnn Greco, Dmitry Gerashchenko
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(18)
Hypocretins (Hcrts) are recently discovered peptides linked to the human sleep disorder narcolepsy. Humans with narcolepsy have decreased numbers of Hcrt neurons and Hcrt-null mice also have narcoleptic symptoms. Hcrt neurons are located only in the
Autor:
Paul Morley, Jon P. Durkin, Roger Tremblay, Kimberley Hewitt, Trevor Atkinson, Balu Chakravarthy, Joseph S. Tauskela
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(19)
NMDA receptor antagonists, such as (+)-5-methyl-10, 11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine maleate (MK-801), potently block glutamate-induced neuronal death in myriad in vitro cell models and effectively attenuate ischemic damage in vivo.
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(7)
Because injury of the CNS causes an astrogliosis, characterized by cell swelling and proliferation, similar to the effects of the serine protease thrombin on astrocytes, we hypothesized that a high level of thrombin at the site of injury might initia
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(19)
We have previously shown that NMDA receptor activation during status epilepticus (SE) is required to produce epilepsy inin vitroandin vivomodels. As in human symptomatic epilepsy, the epilepsy in these models is permanent, suggesting that the patholo
Autor:
Mary Jo LaDu, Richard J. Miller, Catherine A. Reardon, Joaquín Jordán, Maria F. Galindo, Godfrey S. Getz
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 18(1)
Although the genetic link between the epsilon4 allele of apolipoprotein E (apoE) and Alzheimer's disease is well established, the isoform-specific activity of apoE underlying this correlation remains unclear. To determine whether apoE influences the