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Autor:
Xian Xiao, Jin Cheng, Xiang Wang, Ye Yu, Wei Guang Li, Tian Le Xu, Michael X. Zhu, Zhong Peng, Wei-Zheng Zeng
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(10)
Tissue acidosis and inflammatory mediators play critical roles in inflammatory pain. Extracellular acidosis activates acid-sensing ion channels (ASICs), which have emerged as key sensors for extracellular protons in the central and peripheral nervous
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(30)
Modulation of GABAAreceptor function and inhibitory synaptic transmission by phosphorylation has profound consequences for the control of synaptic plasticity and network excitability. We have established that activating α-calcium/calmodulin-dependen
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(24)
Transient receptor potential V2 (TRPV2) has been proposed to be a high-threshold thermosensor. However, further elucidation of the channel properties and physiological role of TRPV2 have been hindered by the lack of selective pharmacological tools as
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(3)
Intranigral injection of the transient receptor potential vanilloid subtype 1 (TRPV1; also known as VR1) agonist capsaicin (CAP) into the rat brain, or treatment of rat mesencephalic cultures with CAP, resulted in cell death of dopaminergic (DA) neur
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(32)
The ionotropic and cytolytic P2X7receptor is typically found on immune cells, where it is involved in the release of cytokines. Recently, P2X7receptors were reported to be localized to presynaptic nerve terminals and to modulate transmitter release.
Autor:
Paul Morley, Jon P. Durkin, Roger Tremblay, Kimberley Hewitt, Trevor Atkinson, Balu Chakravarthy, Joseph S. Tauskela
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(19)
NMDA receptor antagonists, such as (+)-5-methyl-10, 11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine maleate (MK-801), potently block glutamate-induced neuronal death in myriad in vitro cell models and effectively attenuate ischemic damage in vivo.
Autor:
Stuart A. Lipton, Zhuo Hua Pan
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 15(4)
Inhibitory effects of GABA on K(+)-evoked Ca2+ influx into rat retinal bipolar cell terminals were studied using calcium imaging methods. Application of high K+ evokes a sustained, reversible increase in [Ca2+]i at bipolar cell terminals, which occur
Autor:
R. A. North, Ke Zhong Shen
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 13(3)
ATP and several congeners were applied to locus coeruleus neurons in slices cut from rat pons. Whole-cell recording of membrane current showed that ATP caused an inward current at -60 mV. Effective concentrations (applied by superfusion) were 3-300 m
Loss of acetylcholine receptor clusters induced by treatment of cultured rat myotubes with carbachol
Autor:
RJ Bloch
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 6(3)
Prolonged exposure to carbachol disrupts the acetylcholine receptor (AChR) clusters of cultured rat myotubes without causing myotube loss. The effect is reversible, and is dependent on temperature. Half-maximal cluster loss is achieved at 3 microM ca