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Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(37)
Over the past few years, δ-opioid receptors (DOPRs) and μ-opioid receptors (MOPRs) have been shown to interact with each other. We have previously seen that expression of MOPR is essential for morphine and inflammation to potentiate the analgesic p
Autor:
Eric J. Nestler, Ming-Hu Han, Scott Edwards, Kimberly N. Whisler, Diana Simmons, Erin B. Larson, Kwang H. Choi, Amelia J. Eisch, Zia Ur Rahman, Lisa M. Monteggia, David W. Self, Danielle Graham, Rachael L. Neve, Allyson K. Friedman, Jessica J. Walsh
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(21)
Chronic cocaine use produces numerous biological changes in brain, but relatively few are functionally associated with cocaine reinforcement. Here we show that daily intravenous cocaine self-administration, but not passive cocaine administration, ind
Autor:
Allan I. Levey, D. H. Snyder, Zixiu Xiang, James J. Doherty, Thomas M. Bridges, Jack Philip Kennedy, Albert A. Davis, Edward P. Christian, Jana K. Shirey, Ashley E. Brady, Michelle M. Nicolle, Satyawan Jadhav, Usha N. Menon, P.J. Conn, Michael C. Quirk, M. L. Watson, J. J. Lah, Paulianda J. Jones, Craig W. Lindsley
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(45)
M1muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment of disorders involving impaired cognitive function. However, a major limitation to testing this hypothesis has been a lack of highly selective ligands for indiv
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(23)
Cortical networks spontaneously fluctuate between persistently active Up states and quiescent Down states. The Up states are maintained by recurrent excitation within local circuits, and can be turned on and off by synaptic input. GABAergic inhibitio
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(10)
Adolescence is a transitional period during development that is associated with a greater likelihood of addiction to drugs than any other age. In the prefrontal cortex (PFC), D1dopamine receptors mediate motivational salience attribution, which plays
Autor:
Cheng Fang, Masaki Fukata, Gong Chen, Yuko Fukata, Bernhard Lüscher, Cheryl A. Keller, Lunbin Deng
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(49)
Golgi-specific DHHC (Asp-His-His-Cys) zinc finger protein (GODZ) is a DHHC family palmitoyl acyltransferase that is implicated in palmitoylation and regulated trafficking of diverse substrates that function either at inhibitory or excitatory synapses
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(47)
Typically, D1 and D2 dopamine (DA) receptors exert opposing actions on intracellular signaling molecules and often have disparate physiological effects; however, the factors determining preferential activation of D1 versus D2 signaling are not clear.
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(26)
Extracellular signal-regulated kinase (ERK) 1/2, a well known regulator of gene expression, is likely to contribute to signaling events underlying enduring neural adaptations. Phosphorylated (phospho)-ERK was examined immunohistochemically after both
Autor:
Zheng-Xiong Xi, Russell W. Lake, Peter W. Kalivas, Hui Shen, Devadoss J. Samuvel, Sammanda Ramamoorthy
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(8)
Repeated cocaine causes enduring changes in dopamine and glutamate transmission in the nucleus accumbens, and dopamine and glutamate terminals synapse on GABAergic accumbens neurons. The present study demonstrates that there are changes in GABA trans
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(1)
A remarkable feature of opioids is that they inhibit pain that persists from previous injuries without eliminating either the initial pain of a new injury or the protective reflexes triggered by it. Here we ask whether selective expression of the mu-