Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bruce R. Ransom"'
Autor:
Davin Gong, Jonathan R. Weinstein, Jamie R. Colman, Thu Le, Richard V. Lee, Margaret A. Hamner, Bruce R. Ransom, Zucheng Ye
Publikováno v:
The Journal of Neuroscience. 35:15599-15611
Ischemic preconditioning (IPC) is a robust neuroprotective phenomenon whereby brief ischemic exposure confers tolerance to a subsequent ischemic challenge. IPC has not been studied selectively in CNS white matter (WM), although stroke frequently invo
Autor:
Nancy Ann Oberheim, Takahiro Takano, Xiaoning Han, Wei He, Jane H. C. Lin, Fushun Wang, Qiwu Xu, Jeffrey D. Wyatt, Webster Pilcher, Jeffrey G. Ojemann, Bruce R. Ransom, Steven A. Goldman, Maiken Nedergaard
Publikováno v:
The Journal of Neuroscience. 29:3276-3287
Defining the microanatomic differences between the human brain and that of other mammals is key to understanding its unique computational power. Although much effort has been devoted to comparative studies of neurons, astrocytes have received far les
Autor:
Selva Baltan, Brianna Mbow, Zu Cheng Ye, Bruce R. Ransom, Margaret A. Hamner, Elaine Besancon
Publikováno v:
The Journal of Neuroscience. 28:1479-1489
Stroke incidence increases with age and this has been attributed to vascular factors. We show here that CNS white matter (WM) is intrinsically more vulnerable to ischemic injury in older animals and that the mechanisms of WM injury change as a functi
Publikováno v:
The Journal of Neuroscience. 23:3588-3596
Little is known about the expression and possible functions of unopposed gap junction hemichannels in the brain. Emerging evidence suggests that gap junction hemichannels can act as stand-alone functional channels in astrocytes. With immunocytochemis
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
We studied the effects of GABA on anoxia-induced injury in CNS white matter using optic nerves exposed to 60 min of anoxia. Injury was assessed by recording pre- and postanoxic compound action potentials (CAPs). GABA (1 microM) significantly increase
Publikováno v:
The Journal of Neuroscience. 12:430-439
White matter of the mammalian CNS suffers irreversible injury when subjected to anoxia/ischemia. However, the mechanisms of anoxic injury in central myelinated tracts are not well understood. Although white matter injury depends on the presence of ex
Publikováno v:
Scopus-Elsevier
Activity-dependent shrinkage of extracellular space (ECS) is described in a simple model of the mammalian central nervous system, the rat optic nerve. In response to neural activation, the ECS of the mature nerve rapidly and reversibly decreases by a