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Publikováno v:
The Journal of Neuroscience. 41:9065-9081
Stimulatory coupling of dopamine D1(D1R) and adenosine A2Areceptors (A2AR) to adenylyl cyclase within the striatum is mediated through a specific Gαolfβ2γ7heterotrimer to ultimately modulate motor behaviors. To dissect the individual roles of the
Autor:
Mahomi Kuroiwa, Akinori Nishi, Yukie Kawahara, Yoshinori N. Ohnishi, Takaichi Fukuda, Takahide Shuto, Keita Sugiyama, Yuta Miyamoto
Publikováno v:
J Neurosci
The Journal of neuroscience 41(30):6388-6414, 2021
The Journal of neuroscience 41(30):6388-6414, 2021
The striatum is the main structure of the basal ganglia. The striatum receives inputs from various cortical areas, and its subregions play distinct roles in motor and emotional functions. Recently, striatal maps based on corticostriatal connectivity
Autor:
Anna Blasiak, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Anna Gugula, Patryk Sambak, Ewa Błasiak, Grzegorz Hess, Agata Szlaga, Andrew L. Gundlach, Alan Kania, Mohammad Akhter Hossain
Publikováno v:
The Journal of Neuroscience
Binge-eating disorder is the most common eating disorder. Various neuropeptides play important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which stimulates food intake in rats through the activation of the relaxin-family
Autor:
Rosalba Satta, Mark S. Brodie, Bertha J. Vandegrift, Pingwen Xu, Chang You, Hu Chen, Donghong He, Amy W. Lasek, Rex Tai, Elisa R. Hilderbrand, Cassandre Coles
Publikováno v:
J Neurosci
Elevations in estrogen (17β-estradiol, E2) are associated with increased alcohol drinking by women and experimentally in rodents. E2 alters the activity of the dopamine system, including the VTA and its projection targets, which plays an important r
Autor:
Lori L. McMahon, David G. Standaert, Karen L. Eskow Jaunarajs, Mariangela Scarduzio, Michelle E. Ehrlich
Publikováno v:
The Journal of Neuroscience. 39:7195-7205
Clinical and experimental data indicate striatal cholinergic dysfunction in dystonia, a movement disorder typically resulting in twisted postures via abnormal muscle contraction. Three forms of isolated human dystonia result from mutations in the TOR
Autor:
Shaodong Zhang, Claudia Mattern, Magalie Fréchou, Antoine Pianos, Christian Denier, Philippe Liere, Xiaoyan Zhu, Rachida Guennoun, Michael Schumacher, Neïké Fernandez
Publikováno v:
Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2017, epub ahead of print. ⟨10.1523/JNEUROSCI.3874-16.2017⟩
Journal of Neuroscience, Society for Neuroscience, 2017, epub ahead of print. ⟨10.1523/JNEUROSCI.3874-16.2017⟩
Treatment with progesterone protects the male and female brain against damage after middle cerebral artery occlusion (MCAO). However, in both sexes, the brain contains significant amounts of endogenous progesterone. It is not known whether endogenous
Publikováno v:
The Journal of Neuroscience. 37:9686-9704
Memantine and ketamine are clinically useful NMDA receptor (NMDAR) open channel blockers that inhibit NMDARs with similar potency and kinetics, but display vastly different clinical profiles. This discrepancy has been hypothesized to result from inhi
Publikováno v:
The Journal of Neuroscience. 37:8742-8754
Repeated alcohol intake leads to mesostriatal neuroadaptations, resulting in drinking escalation and addiction phenotypes. Fibroblast growth factor 2 (FGF2) has been shown to interact with the mesostriatal dopaminergic system, and has been implicated
Publikováno v:
The Journal of Neuroscience. 37:5562-5573
The use of angiotensin receptor blockers (ARBs) correlates with reduced onset and progression of Alzheimer's disease (AD). The mechanism depicting how ARBs such as losartan restore cerebrovascular and cognitive deficits in AD is unknown. Here, we pro
Autor:
Melissa D. Giraldo, Daniel J. Shiwarski, Brigitte F. Schmidt, Amynah A. Pradhan, Manojkumar A. Puthenveedu, Michael S. Gold, Alycia F Tipton
Publikováno v:
The Journal of Neuroscience. 37:3741-3752
The δ opioid receptor (δR) is a promising alternate target for pain management because δR agonists show decreased abuse potential compared with current opioid analgesics that target the μ opioid receptor. A critical limitation in developing δR a