Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Eric L. Nuermberger"'
Autor:
Sandeep Tyagi, Kala Barnes-Boyle, Kelly E. Dooley, Rada M. Savic, Amelia N. Deitchman, Si Yang Li, Heena Soni, Kristina M. Bigelow, Eric L. Nuermberger
Publikováno v:
The Journal of Infectious Diseases
The Journal of infectious diseases, vol 223, iss 11
The Journal of infectious diseases, vol 223, iss 11
Background Linezolid (LZD) is bactericidal against Mycobacterium tuberculosis, but it has treatment-limiting toxicities. A better understanding of exposure-response relationships governing LZD efficacy and toxicity will inform dosing strategies. Beca
Publikováno v:
The Journal of infectious diseases. 211
Background Several nonclinical drug-development tools (DDTs) have been used for antituberculosis drug development over several decades. The role of the DDTs used for evaluating the efficacy of antituberculosis drug combinations and the gaps in the ev
Autor:
Eric L. Nuermberger, Sanjay K. Jain, Stephanie L. Davis, Mariah Weir, Rokeya Tasneen, William R. Bishai, Jamie Harper, Igor Kramnik, Ciaran Skerry, Martin G. Pomper
Publikováno v:
The Journal of infectious diseases. 205(4)
With few exceptions, current preclinical evaluation of new tuberculosis drug candidates in animals is limited to mice. Mice are relatively inexpensive and permit investigation of disease mechanisms given the wide availability of reagents. However, th
Autor:
Michael L. Pinn, William R. Bishai, Mostafa Fraig, Petros C. Karakousis, Lee G. Klinkenberg, Charles A. Peloquin, Zahoor Ahmad, Eric L. Nuermberger, Jacques H. Grosset
Publikováno v:
The Journal of infectious diseases. 200(7)
The marked reduction in the potent early bactericidal activity of isoniazid during the initial phase of antituberculosis (anti-TB) therapy has been attributed not only to the depletion of logarithmically growing bacilli but also to the emergence of i
Autor:
Norman E. Morrison, Paul J. Converse, Gyanu Lamichhane, Prabhpreet Singh, Jacques H. Grosset, Lan H. Ly, Lee G. Klinkenberg, Qi-Jian Cheng, David N. McMurray, William R. Bishai, Sanjay K. Jain, S. Moises Hernandez-Abanto, Eric L. Nuermberger, Petros C. Karakousis
Publikováno v:
The Journal of infectious diseases. 195(11)
Background. Mouse and guinea pig models have been used to identify Mycobacterium tuberculosis mutants attenuated for survival. However, unlike mice, M. tuberculosis-infected guinea pigs form caseating granulomas, which may simulate human disease more