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Publikováno v:
J Infect Dis
Background Rapid diagnostic tests based on detection of histidine-rich proteins (HRPs) are widely used for malaria diagnosis, but parasites carrying pfhrp deletions can evade detection and are increasing in frequency in some countries. Models aim to
Autor:
Cooper K Hayes, Christopher K Villota, Fiona B McEnany, Stacey Cerón, Sita Awasthi, Moriah L Szpara, Harvey M Friedman, David A Leib, Richard Longnecker, Matthew D Weitzman, Lisa N Akhtar
Publikováno v:
J Infect Dis
Herpes simplex virus (HSV) infection of the neonatal brain causes severe encephalitis and permanent neurologic deficits. However, infants infected with HSV at the time of birth follow varied clinical courses, with approximately half of infants experi
Autor:
Tsun-Yung Kuo, Chia En Lien, Yi-Jiun Lin, Meei-Yun Lin, Chung-Chin Wu, Wei-Hsuan Tang, John D Campbell, Paula Traquina, Ya-Shan Chuang, Luke Tzu-Chi Liu, Jinyi Cheng, Charles Chen
Publikováno v:
The Journal of infectious diseases. 226(9)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern negatively impact the effectiveness of vaccines. In this study, we challenge hamsters with the delta variant after 2- or 3-dose inoculations with SARS-CoV-2 vaccines con
Autor:
IkRak Jung, Becky Tu-Sekine, Sunghee Jin, Frederick Anokye-Danso, Rexford S Ahima, Todd T Brown, Sangwon F Kim
Publikováno v:
J Infect Dis
Background Antiretroviral therapy (ART) containing integrase strand transfer inhibitors (INSTIs) has been associated with weight gain in both ART initiation and switch studies, especially in women, but the underlying mechanisms are unclear. Methods T
Autor:
Sangphil Moon, Ibo Janssens, Kyung Hyun Kim, Benoit Stijlemans, Stefan Magez, Magdalena Radwanska
Publikováno v:
The Journal of infectious diseases. 226(3)
Background Trypanosoma brucei brucei evades host immune responses by multiple means, including the disruption of B-cell homeostasis. This hampers anti-trypanosome vaccine development. Because the cellular mechanism underlying this pathology has never
Autor:
Yufei Zhang, Jindong Gao, Kun Huang, Ya Zhao, Xianfeng Hui, Ting Wang, Changmin Hu, Xiaomei Sun, Ying Yang, Chao Wu, Xi Chen, Zhong Zou, Lian zong Zhao, Meilin Jin
Publikováno v:
The Journal of infectious diseases. 226(9)
Isolated reports of new-onset diabetes in patients with coronavirus disease 2019 (COVID-19) have led researchers to hypothesize that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects human exocrine and endocrine pancreatic cells ex
Autor:
Julia Li, Sabine Wellnitz, Xiaoyuan S Chi, Yujuan Yue, Kimberli A Schmidt, Nancy Nguyen, Wei Chen, Irina Yurgelonis, Eduardo Rojas, Yuhang Liu, Jakob Loschko, Eneida Pollozi, Yury V Matsuka, Elie Needle, Eugene Vidunas, Robert G K Donald, Justin Moran, Kathrin U Jansen, Philip R Dormitzer, Peter A Barry, Xinzhen Yang
Publikováno v:
J Infect Dis
The development of a vaccine to prevent congenital human cytomegalovirus (HCMV) disease is a public health priority. We tested rhesus CMV (RhCMV) prototypes of HCMV vaccine candidates in a seronegative macaque oral challenge model. Immunogens include
Autor:
Ryan, Kathryn A, Schewe, Katarzyna E, Crowe, Jonathan, Fotheringham, Susan A, Hall, Yper, Humphreys, Richard, Marriott, Anthony C, Paterson, Jemma, Rayner, Emma, Salguero, Francisco J, Watson, Robert J, Whittaker, Catherine J, Carroll, Miles W, Dibben, Oliver
Publikováno v:
The Journal of Infectious Diseases
Cocirculation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses could pose unpredictable risks to health systems globally, with recent studies suggesting more severe disease outcomes in coinfected patients. The ini
Autor:
Susanna F. Greer, Zehava Eichenbaum, Ya Shu Huang, Nilanjana Chatterjee, Lawrence M. Kauvar, Kristin V. Lyles, Julie E. Morgan
Publikováno v:
J Infect Dis
Background A vaccine against group A Streptococcus (GAS) has been actively pursued for decades. The surface receptor Shr is vital in GAS heme uptake and provides an effective target for active and passive immunization. Here, we isolated human monoclo
Autor:
Zhan Zhang, Benoit Chassaing, Jun Zou, Xu Zhao, Zhenda Shi, Matam Vijay-Kumar, Andrew T. Gewirtz
Publikováno v:
The Journal of Infectious Diseases
J Infect Dis
J Infect Dis
Background Bacterial flagellin is a major target of innate and adaptive immunity, both of which can promote and/or compensate for deficiencies in each other’s function. Methods To investigate the role of innate immune detection of flagellin irrespe