Zobrazeno 61 - 70
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Autor:
Jean Francois Lauzon-Joset, Deborah H. Strickland, Naomi M. Scott, Philip A. Stumbles, Kyle T Mincham, Patrick G. Holt
Publikováno v:
The Journal of infectious diseases. 219(11)
Background Influenza virus infection during pregnancy is associated with enhanced disease severity. However, the underlying mechanisms are still not fully understood. We hypothesized that normal alveolar macrophage (AM) functions, which are central t
Publikováno v:
The Journal of infectious diseases. 221(7)
Background Stimulator of interferon genes (STING) is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. Cyclic dinucleotide STING agonists may comprise a novel class of vaccine adjuvants capable
Publikováno v:
The Journal of infectious diseases. 219(2)
Preexisting immunity to Zika virus (ZIKV) or dengue virus (DENV) may alter the course of their infection, and here we use robust mouse models to examine pathological outcomes following passive immunization, sequential cross-infection, or vaccination
Autor:
Muhammad Ali Shah, Habib Bukhari, Joan Colom, Brendan W. Wren, Paul A. Barrow, Jingliang Su, Banwarilal Sarkar, Robert J. Atterbury, Abiyad Baig, Jenny M Ritchie, S. G. Bhandare
Publikováno v:
J Infect Dis
Cholera remains a major risk in developing countries, particularly after natural or man-made disasters. Vibrio cholerae El Tor is the most important cause of these outbreaks, and is becoming increasingly resistant to antibiotics, so alternative thera
Publikováno v:
The Journal of infectious diseases. 218(suppl_5)
Marburg virus (MARV), family Filoviridae, causes Marburg hemorrhagic fever (MHF) in humans and nonhuman primates with case fatality rates of up to 90%. There is no approved therapeutic for MHF, yet several experimental approaches have been evaluated
Autor:
James F. Papin, Leslie D Wagner, Roman F. Wolf, Tod J. Merkel, Parul Kapil, Lindsey I. Zimmerman
Publikováno v:
The Journal of infectious diseases. 217(8)
Background Bordetella pertussis is a human pathogen responsible for serious respiratory illness. The disease is most severe in infants too young to be vaccinated with most hospitalizations and deaths occurring within this age group. The Advisory Comm
Autor:
Ousmane A. Koita, Donald J. Krogstad
Publikováno v:
The Journal of infectious diseases. 217(5)
Autor:
Juan J. Marugan, Andrés E. Dulcey, Takuro Uchida, Marc Singleton, T. Jake Liang, Adam Rolt, Pranav Shah, Xin Xu, Emma Hughes, Michio Imamura, Amy Wang, Derek Le, Kazuaki Chayama, Zongyi Hu, Shanshan He
Publikováno v:
The Journal of infectious diseases. 217(11)
Hepatitis C virus (HCV) is a small, single-stranded, positive-sense RNA virus that infects more than an estimated 70 million people worldwide. Untreated, persistent HCV infection often results in chronic hepatitis, cirrhosis, or liver failure, with p
Autor:
Alan Schumitzky, Michael Neely, Steven Fikes, David Brown, Michael VanGuilder, Dodge Baluya, Arnold Louie, Roger W. Jelliffe, Stephanie Kurhanewicz, George L. Drusano, Weiguo Liu, Nichole Robbins
Publikováno v:
The Journal of Infectious Diseases. 211:1326-1333
Background. Meropenem plus levofloxacin treatment was shown to be a promising combination in our in vitro hollow fiber infection model. We strove to validate this finding in a murine Pseudomonas pneumonia model. Methods. A dose-ranging study with mer
Autor:
Femke-Anouska Heinsen, Beatriz Martínez-Vallespín, Lukasz Grzeskowiak, Wilfried Vahjen, Salah Amasheh, Knut Reinert, Temesgen Hailemariam Dadi, Jürgen Zentek, Robert Pieper, Judith Radloff, Andre Franke
Publikováno v:
The Journal of infectious diseases. 217(9)
Spontaneous outbreaks of Clostridium difficile infection (CDI) occur in neonatal piglets, but the predisposing factors are largely not known. To study the conditions for C. difficile colonization and CDI development, 48 neonatal piglets were moved in