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of 36
pro vyhledávání: ''
Autor:
Sandra Persson, Monica L. Vieira, Eliete Caló Romero, Karin Kirchgatter, Ana L. T. O. Nascimento, Heiko Herwald, Mônica Lopes-Ferreira
Publikováno v:
The Journal of Infectious Diseases. 219:996-1006
BACKGROUND: Leptospirosis, caused by spirochetes of the genus Leptospira, is one of the most widespread zoonoses worldwide. Efficient diagnostic methods for early diagnosis of leptospirosis are still lacking, and acute disease presents with nonspecif
Autor:
Bren E Sedmak, Sanjay Varikuti, Abhay R. Satoskar, Gregory Halsey, Noushin Saljoughian, Nathan Ryan, Gabriella R. Seidler, Greta Volpedo, Tracey L. Papenfuss, Steve Oghumu, Omar Hamza
Publikováno v:
The Journal of Infectious Diseases. 219:599-608
Background New drugs are needed for leishmaniasis because current treatments such as pentavalent antimonials are toxic and require prolonged administration, leading to poor patient compliance. Ibrutinib is an anticancer drug known to modulate T-helpe
Autor:
Martin MacDonald, Penny A. Rudd, Michael S. Rolph, Kirsten Spann, Keiko Kan-o, Belinda J. Thomas, Philip G. Bardin, Ruben Ramirez, Suresh Mahalingam
Publikováno v:
The Journal of Infectious Diseases. 215:1536-1545
BACKGROUND.: Human metapneumovirus (hMPV) infection is implicated in exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Research into the pathogenesis of infection is restricted to animal models, and information about hMPV repl
Autor:
Jean Francois Lauzon-Joset, Deborah H. Strickland, Naomi M. Scott, Philip A. Stumbles, Kyle T Mincham, Patrick G. Holt
Publikováno v:
The Journal of infectious diseases. 219(11)
Background Influenza virus infection during pregnancy is associated with enhanced disease severity. However, the underlying mechanisms are still not fully understood. We hypothesized that normal alveolar macrophage (AM) functions, which are central t
Publikováno v:
The Journal of infectious diseases. 217(4)
During influenza pandemics, secondary pneumococcal infections cause excessive mortality. However, the current 13-valent pneumococcal conjugate vaccine, PCV13, provides only limited protection against secondary infection. Therefore, a more effective p
Autor:
Anatole Tounkara, Mariama C. Maiga, William R. Bishai, Nicole C. Ammerman, Robert L. Murphy, Sophia Siddiqui, Michael A. Polis, Mamoudou Maiga
Publikováno v:
The Journal of Infectious Diseases. 208:512-519
Background. Shortening tuberculosis treatment could significantly improve patient adherence and decrease the development of drug resistance. Phosphodiesterase inhibitors (PDE-Is) have been shown to be beneficial in animal models of tuberculosis. We a
Publikováno v:
The Journal of infectious diseases. 214(1)
BACKGROUND Brucella species are facultative intracellular gram-negative bacteria that cause brucellosis, a common global zoonosis. Infection of the joints is the most common focal complication of brucellosis in humans. The purpose of this study was t
Autor:
Mike Bray, Steven Jones, Judie B. Alimonti, Ute Ströher, Hans-Dieter Klenk, Lisa Fernando, Heinz Feldmann, Xianggou Qiu, Pasquale L. Melito
Publikováno v:
The Journal of Infectious Diseases. 196:S404-S412
Background. In humans and nonhuman primates, Ebola virus causes a virulent viral hemorrhagic fever for which no licensed vaccines or therapeutic drugs exist. In the present study, we used the mouse model for Ebola hemorrhagic fever to assess the safe
Autor:
Arnold Louie, Lawrence J. Sullivan, Jennifer Bassett, Henry S. Heine, Fritz Sörgel, Lynda Miller, George L. Drusano, Martina Kinzig-Schippers
Publikováno v:
The Journal of Infectious Diseases. 196:782-787
Introduction. Intentional release of Yersinia pestis will likely be propagated by aerosol exposure. We explored the effects of neutropenia on the outcome of doxycycline and gentamicin therapy. Methods. Female BALB/c mice were exposed to 20 LD 50 of Y
Publikováno v:
The Journal of infectious diseases. 212(2)
This study examined the therapeutic and prophylactic potential of bacteriophages in a mouse model of Klebsiella pneumoniae lobar pneumonia. Phages were administered intraperitoneally. Liposome-entrapped phages (LP) were effective in treating infectio