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Publikováno v:
J Infect Dis
Pertussis, caused by Bordetella pertussis, is a reemerging disease that can produce severe disease manifestations in infants, including pulmonary hypertension (PH). B. pertussis-induced PH is a major risk factor for infection-induced death, but the m
Autor:
Mélanie Foulon, Marie Robbe-Saule, Lucille Esnault, Marine Malloci, Anthony Mery, Jean-Paul Saint-André, Anne Croue, Marie Kempf, Chadi Homedan, Estelle Marion, Laurent Marsollier
Publikováno v:
The Journal of Infectious Diseases. 224:1973-1983
Ketogenic diets have been used to treat diverse conditions, and there is growing evidence of their benefits for tissue repair and in inflammatory disease treatment. However, their role in infectious diseases has been little studied. Buruli ulcer (Myc
Autor:
Amber M. Smith, Amanda P. Smith, Jonathan A. McCullers, Peter Vogel, Rhiannon R. Penkert, Julia L. Hurwitz, Eike R. Hrincius
Publikováno v:
J Infect Dis
Background Secondary bacterial coinfections are ranked as a leading cause of hospitalization and morbid conditions associated with influenza. Because vitamin A deficiency (VAD) and insufficiency are frequent in both developed and developing countries
Publikováno v:
J Infect Dis
Background Immunocompromised patients infected with influenza virus require prolonged treatment with neuraminidase inhibitors, because these patients are not able to eradicate the virus from the respiratory tract, leading to the emergence of drug-res
Autor:
Smriti Mehra, Abigail Gerberick, Qian Wu, Daniel J. Wozniak, Murugesan V. S. Rajaram, Latha P. Ganesan, Austin P Hossfeld, Charu Tiwari, Noushin Saljoughian
Publikováno v:
The Journal of Infectious Diseases. 220:1989-1998
Background Tuberculosis is caused by Mycobacterium tuberculosis. Recent emergence of multidrug-resistant (MDR) tuberculosis strains seriously threatens tuberculosis control and prevention. However, the role of macrophage multidrug resistance gene MDR
Autor:
Rama Subba Rao Vidadala, Grant R. Whitman, Carlie S. Dorr, Molly C. McCloskey, Ryan Choi, Mansi Khatod, Samuel L.M. Arnold, Mary Morada, Wesley C. Van Voorhis, Nigel Yarlett, Dustin J. Maly, Lynn K. Barrett, Matthew A. Hulverson
Publikováno v:
The Journal of Infectious Diseases
Recent studies have illustrated the burden Cryptosporidium infection places on the lives of malnourished children and immunocompromised individuals. Treatment options remain limited, and efforts to develop a new therapeutic are currently underway. Ho
Autor:
George Sakoulas, Hannah Tsunemoto, Erlinda R. Ulloa, Nicholas Dillon, Victor Nizet, Joe Pogliano
Publikováno v:
The Journal of Infectious Diseases
Infections caused by New Delhi metallo-β-lactamase (NDM)–producing strains of multidrug-resistant Klebsiella pneumoniae are a global public health threat lacking reliable therapies. NDM is impervious to all existing β-lactamase inhibitor (BLI) dr
Autor:
Jerry Ware, Alex F. de Vos, Gavin C. K. W. Koh, Direk Limmathurotsakul, W. Joost Wiersinga, Nicholas P. J. Day, Theodora A. M. Claushuis, Tom van der Poll, Joris J. T. H. Roelofs, Emma Birnie, Cornelis van 't Veer, Baidong Hou
Publikováno v:
The Journal of Infectious Diseases
Journal of infectious diseases, 219(4), 648-659. Oxford University Press
Journal of infectious diseases, 219(4), 648-659. Oxford University Press
Thrombocytopenia predicts mortality in melioidosis patients and during experimental melioidosis, platelets play a protective role in both innate immunity and vascular integrity.
Background Infection with the gram-negative bacillus Burkholderia p
Background Infection with the gram-negative bacillus Burkholderia p
Autor:
Bren E Sedmak, Sanjay Varikuti, Abhay R. Satoskar, Gregory Halsey, Noushin Saljoughian, Nathan Ryan, Gabriella R. Seidler, Greta Volpedo, Tracey L. Papenfuss, Steve Oghumu, Omar Hamza
Publikováno v:
The Journal of Infectious Diseases. 219:599-608
Background New drugs are needed for leishmaniasis because current treatments such as pentavalent antimonials are toxic and require prolonged administration, leading to poor patient compliance. Ibrutinib is an anticancer drug known to modulate T-helpe
Monoclonal Antibody Requires Immunomodulation for Efficacy Against Acinetobacter baumannii Infection
Autor:
Brian Luna, Matthew Slarve, Jun Yan, Brad Spellberg, Robert A. Bonomo, Yuli Talyansky, Travis B. Nielsen
Publikováno v:
J Infect Dis
Monoclonal antibodies (mAbs) are gaining significant momentum as novel therapeutics for infections caused by antibiotic-resistant bacteria. We evaluated the mechanism by which antibacterial mAb therapy protects against Acinetobacter baumannii infecti