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Autor:
David L. Swerdlow, Luis Jodar, Yasmeen Agosti, Heinz-Josef Schmitt, John M McLaughlin, Farid Khan, Eric A. F. Simões
Publikováno v:
The Journal of Infectious Diseases. 225:1100-1111
Background Although global reviews of infant respiratory syncytial virus (RSV) burden exist, none have summarized data from the United States or evaluated how RSV burden estimates are influenced by variations in study design. Methods We performed a s
Autor:
Curtis Dobrowolski, Michael F. Para, Jonathan Karn, Joshua C. Cyktor, Edward P. Acosta, Ronald T. Mitsuyasu, Joseph Hesselgesser, Joan Dragavon, Evgenia Aga, Rajesh T. Gandhi, Bernard J.C. Macatangay, John W. Mellors, Deborah McMahon, Catherine Godfrey, Lu Zheng
Publikováno v:
J Infect Dis
Background Romidepsin (RMD) is a histone deacetylase inhibitor reported to reverse HIV-1 latency. We sought to identify doses of RMD that were safe and induced HIV-1 expression. Methods Enrollees had HIV-1 RNA Results In the single-dose cohorts 1–3
Autor:
Manohar Mutnal, Arundhati Rao, Yuwei Zhu, Lisa M Keong, Laura Adams, Juliana DaSilva, Lydia Clipper, Kempapura Murthy, Kailey Hughes, John W Williams, Briana Krantz, Claudia Guevara Pulido, Mary Patricia Nowalk, Emily R Smith, Jill M. Ferdinands, Thomas J. Stark, Joshua G. Petrie, Rendi McHenry, Karen Speer, Manish M. Patel, Natasha B. Halasa, Helen Talbot, Ryan E. Malosh, Shekhar Ghamande, Emily T. Martin, Sean G Saul, Lori Stiefel, Lynn Peterson, Kelsey Bounds, Chandni Raiyani, Alejandro Arroliga, Donna Carillo, Kevin Chang, Goundappa K. Balasubramani, Stephanie Longmire, Kellie Graves, Donald B Middleton, Heather Eng, Dayna Wyatt, Tnelda Zunie, Emily Sedillo, Jan Orga, Alina Simion, Mohamed Yassin, Zhouwen Liu, Anurag Malani, Shoshona Le, Arnold S. Monto, Richard K. Zimmerman, Adam S. Lauring, Fernanda P. Silveira, Heath White, Nicole Wheeler, Lois Lamerato, Bethany Alicie, Amelia Drennan, Manjusha Gaglani
Publikováno v:
J Infect Dis
We estimated vaccine effectiveness (VE) for prevention of influenza-associated hospitalizations among adults during the 2018–2019 influenza season. Adults admitted with acute respiratory illness to 14 hospitals of the US Hospitalized Adult Influenz
Publikováno v:
J Infect Dis
Decades of research have failed to define the pathophysiology of necrotizing enterocolitis (NEC), a devastating pediatric gastrointestinal disorder of preterm infants. However, evidence suggests that host-microbiota interactions, in which microbial d
Autor:
Sam P. Brown, John J. Varga, Joanna B. Goldberg, Yifei Wang, Arlene A. Stecenko, Yiqi Hao, Conan Y. Zhao
Publikováno v:
J Infect Dis
Background Microbiome sequencing has brought increasing attention to the polymicrobial context of chronic infections. However, clinical microbiology continues to focus on canonical human pathogens, which may overlook informative, but nonpathogenic, b
Autor:
Felix Espinoza, Edson D. Moreira, Inge Lefevre, Maria Theresa Alera, Asvini D. Fernando, Mengya Liu, Delia Yu, Pope Kosalaraksa, Luis Rivera, Vianney Tricou, Martina Rauscher, Hector Velásquez, Pujitha Wickramasinghe, Dulanie Gunasekera, Derek Wallace, Lulu Bravo, Luis Martinez Vargas, Xavier Sáez-Llorens, Rivaldo Venâncio da Cunha, Veerachai Watanaveeradej, Astrid Borkowski, Charissa Borja-Tabora, Kleber Giovanni Luz, Edith Johana Rodriguez-Arenales, Chukiat Sirivichayakul, Reynaldo Dietze, Shibadas Biswal, Humberto Reynales, Eduardo López-Medina, LakKumar Fernando
Publikováno v:
The Journal of Infectious Diseases. 225:1521-1532
Background Takeda’s dengue vaccine is under evaluation in an ongoing phase 3 efficacy study; we present a 2-year update. Methods Children (20 099, 4–16 years old) were randomized to receive 2 doses of TAK-003 or placebo 3 months apart and are und
Autor:
Petito, Eleonora, Falcinelli, Emanuela, Paliani, Ugo, Cesari, Enrica, Vaudo, Gaetano, Sebastiano, Manuela, Cerotto, Vittorio, Guglielmini, Giuseppe, Gori, Fabio, Malvestiti, Marco, Becattini, Cecilia, Paciullo, Francesco, De Robertis, Edoardo, Bury, Loredana, Lazzarini, Teseo, Gresele, Paolo, Lapenna, Maria, D’Abbondanza, Marco, Cristallini, Stefano, Franco, Laura, Saccarelli, Luca
Publikováno v:
The Journal of Infectious Diseases
Background Severe acute respiratory syndrome coronavirus 2 infection is associated with hypercoagulability, which predisposes to venous thromboembolism (VTE). We analyzed platelet and neutrophil activation in patients with coronavirus disease 2019 (C
Autor:
Chee Fu Yung, Kee Thai Yeo, Poh Choo Khoo, Bin Huey Quek, Seyed Ehsan Saffari, Mee See How, Jane Swee Peng Sng
Publikováno v:
The Journal of Infectious Diseases. 224:279-287
Background The year-round respiratory syncytial virus (RSV) circulation in tropical regions leads to different transmission patterns and burden of disease among infants born very preterm. Methods We conducted a retrospective cohort study to estimate
Publikováno v:
The Journal of Infectious Diseases. 222:S758-S772
The World Health Organization has set a goal to eliminate hepatitis C virus (HCV) infection as public health threat by 2030. Although the advent of highly effective and tolerable direct-acting antiviral therapy has paved the way for HCV elimination,
Autor:
William C. Weldon, Adebiyi Olowu, Beckie N. Tagbo, Pascal Mkanda, Harish Verma, Visalakshi Jeyaseelan, Kehinde Craig, Roland W. Sutter, Eric Nwaze, Steven M. Oberste, Dorothy O Esangbedo, Kolade Ernest, Roosevelt O Nnani, Chinedu M. Chukwubike, Fiona Braka, Zubairu M Mahmud, Abdullahi Walla Hamisu
Publikováno v:
The Journal of Infectious Diseases. 226:299-307
Background We conducted a trial in Nigeria to assess the immunogenicity of the new bivalent oral poliovirus vaccine + inactivated poliovirus vaccine (bOPV+IPV) immunization schedule and gains in type 2 immunity with addition of second dose of IPV. Th