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Autor:
Anatole Tounkara, Mariama C. Maiga, William R. Bishai, Nicole C. Ammerman, Robert L. Murphy, Sophia Siddiqui, Michael A. Polis, Mamoudou Maiga
Publikováno v:
The Journal of Infectious Diseases. 208:512-519
Background. Shortening tuberculosis treatment could significantly improve patient adherence and decrease the development of drug resistance. Phosphodiesterase inhibitors (PDE-Is) have been shown to be beneficial in animal models of tuberculosis. We a
Autor:
Rita Tewari, Henry M. Staines, Falgun Shah, Ksenija Slavic, Jon K. Pittman, Jean Halbert, Christian Doerig, Mitchell A. Avery, Richard K. Haynes, Serena Pulcini, Sanjeev Krishna
Publikováno v:
Journal of Infectious Diseases; Vol 208
Background. The mechanism of action of artemisinins against malaria is unclear, despite their widespread use in combination therapies and the emergence of resistance. Results. Here, we report expression of PfATP6 (a SERCA pump) in yeast and demonstra
Publikováno v:
The Journal of Infectious Diseases. 208:224-234
(See the editorial commentary by Celum et al on pages 189–91) Oral antiretroviral (ARV) pre-exposure prophylaxis (PrEP) is a new biomedical intervention against human immunodeficiency virus (HIV) transmission with proven efficacy [1–3]. There is
Autor:
Henry F. Chambers, Bret R. Sellman, Gustavo Matute-Bello, Gerard Lina, Osamu Kajikawa, Cédric Badiou, Hoan N. Le, Anna Afasizheva, Binh An Diep, Christine Tkaczyk
Publikováno v:
The Journal of Infectious Diseases. 208:75-82
Background. Linezolid is recommended for treatment of pneumonia and other invasive infections caused by methicillin-resistant Staphylococcus aureus (MRSA). The premise underlying this recommendation is that linezolid inhibits in vivo production of po
Publikováno v:
The Journal of Infectious Diseases. 208:699-704
Methamphetamine (METH) is a drug of abuse that is a potent and highly addictive central nervous system (CNS) stimulant. The blood brain barrier (BBB) is a unique interface that in part functions to prevent microbial invasion of the CNS. The effects o
Autor:
Seidina A. S. Diakite, Mory Doumbouya, Michael P. Fay, Saibou Doumbia, Tatiana M. Lopera-Mesa, Serena Chiang, Karim Traore, Daouda Ndiaye, Drissa Konaté, Abdoul S. Keita, Mahamadou Diakite, Kasia Stepniewska, Rick M. Fairhurst, Juliana M. Sá, Carole A. Long, Jennifer M. Anderson, Amir E. Zeituni
Publikováno v:
The Journal of Infectious Diseases
Artemisinins rapidly kill all asexual blood stages of Plasmodium falciparum [1], including young ring forms before they sequester in the microvessels of vital organs, and are thus more effective than quinolines in reducing malaria morbidity and morta
Autor:
Jeffrey A. Johnson, Roger Paredes, Daniel R. Kuritzkes, Heather J. Ribaudo, Martin R. Jakobsen, Jonathan Z. Li, Michael J. Kozal, Anna Maria Geretti, Michael D. Miller, Karin J. Metzner, Katherine Huppler Hullsiek, Lars Østergaard, Evguenia S. Svarovskaia
Publikováno v:
Journal of Infectious Diseases; Vol 207
The Journal of Infectious Diseases
Li, J Z, Paredes, R, Ribaudo, H, Kozal, M J, Svarovskaia, E S, Johnson, J A, Geretti, A M, Metzner, K J, Jakobsen, M R, Hullsiek, K H, Østergaard, L J, Miller, M D & Kuritzkes, D R 2012, ' Impact of Minority Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Resistance Genotype after Virologic Failure ', The Internet Journal of Infectious Diseases . https://doi.org/10.1093/infdis/jis925
Journal of Infectious Diseases
The Journal of Infectious Diseases
Li, J Z, Paredes, R, Ribaudo, H, Kozal, M J, Svarovskaia, E S, Johnson, J A, Geretti, A M, Metzner, K J, Jakobsen, M R, Hullsiek, K H, Østergaard, L J, Miller, M D & Kuritzkes, D R 2012, ' Impact of Minority Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Resistance Genotype after Virologic Failure ', The Internet Journal of Infectious Diseases . https://doi.org/10.1093/infdis/jis925
Journal of Infectious Diseases
Drug-resistant human immunodeficiency virus type 1 (HIV-1) minority variants increase the risk of virologic failure for first-line nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimens. We performed a pooled analysis to evaluate the re
Autor:
Bram Neirinck, Karin Thevissen, Patrick Van Dijck, Anna Bink, Soňa Kucharíková, Jef Vleugels, Bruno P. A. Cammue
Publikováno v:
The Journal of Infectious Diseases. 206:1790-1797
In this study, we demonstrated that in vitro Candida albicans biofilms grown in the presence of diclofenac showed increased susceptibility to caspofungin. These findings were further confirmed using a catheter-associated biofilm model in rats. C. alb
Autor:
Eric S. Daar, Katie R. Mollan, David W. Haas, Gene D. Morse, Paul E. Sax, Camlin Tierney, Margaret A. Fischl, Ann C. Collier, Heather J. Ribaudo
Publikováno v:
The Journal of Infectious Diseases. 207:420-425
The UGT1A1*28 variant has been associated with hyperbilirubinemia and atazanavir discontinuation. Protocol A5202 randomly assigned human immunodeficiency virus type 1 (HIV-1)-infected patients to receive atazanavir/ritonavir (atazanavir/r) or efavire
Autor:
Michael M. Lederman, M. R. Sandhya Rani, Benigno Rodriguez, Kathy Medvik, Sara J. Conry, Johan K. Sandberg, Alan L. Landay, Ronald E. Blanton, Yngve Falck-Ytter, Donald D. Anthony
Publikováno v:
The Journal of Infectious Diseases. 206:969-973
Disease progression of human immunodeficiency virus type 1 (HIV-1) is associated with immune activation. Activation indices are higher during coinfection of hepatitis C virus (HCV) and HIV. The effect of immune activation on interferon α (IFN-α) th