Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vincenzo Bronte"'
Autor:
Alberto Visintin, Elisa Apolloni, Jessica H. Spitzer, Alessandra Mazzoni, Paolo Serafini, David M. Segal, Vincenzo Bronte, Paola Zanovello
Publikováno v:
The Journal of Immunology. 168:689-695
CD11b+Gr-1+ myeloid suppressor cells (MSC) accumulate in lymphoid organs under conditions of intense immune stress where they inhibit T and B cell function. We recently described the generation of immortalized MSC lines that provide a homogeneous sou
Autor:
Vincenzo Bronte, Michael Wang, Willem W. Overwijk, Deborah R. Surman, Federica Pericle, Steven A. Rosenberg, Nicholas P. Restifo
Publikováno v:
The Journal of Immunology. 161:5313-5320
Following an infection or immunization, a primary CD8+ T cell response generally rises then falls rapidly before giving rise to a “memory” response. When we immunized mice with recombinant viral immunogens optimized to enhance the lytic capabilit
Publikováno v:
The Journal of Immunology. 190:185.9-185.9
Myeloid-derived suppressor cells (MDSCs) are an immunosuppressive population of immature monocytic and granulocytic cells. MDSCs emerge from the bone marrow as inactive precursors and upon migration to sites of inflammation become activated regulator
Autor:
Jessica Haverkamp, Amber Smith, Joseph Qualls, Liza Balouzian, Vincenzo Bronte, Joseph Opferman, Peter Murray
Publikováno v:
The Journal of Immunology. 188:48.11-48.11
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immunosuppressive cells and are identified in mice as Gr-1+ (Ly6G/C) CD11b+ cells with the ability to inhibit T cell proliferation. However, the key functional immunosuppressiv
Autor:
Mathias Oelke, Stefano Ugel, Alessia Zoso, Carmela De Santo, Yu Li, Ilaria Marigo, Paola Zanovello, Elisa Scarselli, Barbara Cipriani, Vincenzo Bronte, Jonathan P. Schneck
Publikováno v:
The Journal of Immunology. 184:131.13-131.13
The development of effective anti-tumor immune responses is normally constrained by low avidity, tumor-specific cytotoxic T lymphocytes (CTL) which are unable to eradicate the tumor. Therefore, new strategies to rescue anti-tumor activity of low avid
Publikováno v:
The Journal of Immunology. 184:131.19-131.19
It has been shown that high avidity tumor-specific CD8+ T cells are superior to low-avidity T cells in anti-tumor activity. However, adoptive transfer of high-avidity CTL populations could still fail as a therapy due to the fact that CTL effector fun
Autor:
Alessia Zoso, Carmela De Santo, Ilaria Marigo, Jonathon Drew Bennet, Paola Zanovello, Jonathan P. Schneck, Vincenzo Bronte, Mathias Oelke
Publikováno v:
The Journal of Immunology. 178:LB31-LB31
The development of effective anti-tumor immune responses is normally constrained by low affinity tumor specific CTL which are unable to eradicate the tumor. Strategies to rescue anti-tumor activity of low affinity melanoma-specific CTL in vivo might