Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ye Zheng"'
Publikováno v:
The Journal of Immunology. 208:167.10-167.10
The maintenance of tissue homeostasis in steady state or under stress is dependent on the proper communication between the stem cells and the supporting cells in their microenvironment or “niche”. In addition to promoting immune tolerance, regula
Publikováno v:
The Journal of Immunology. 206:53.07-53.07
Regulatory T cells (Tregs) play a pivotal role in suppressing auto-reactive T cells and maintaining immune homeostasis. Treg development and function are dependent on the transcription factor Foxp3. Although a large body of work has been devoted to d
Autor:
Jeniffer B Hernandez, Si Cave, Qiyuan Yang, Carl Decker, Jack Swanson, Ezra Wiater, Ye Zheng, Marc Montminy
Publikováno v:
The Journal of Immunology. 206:53.02-53.02
GPR65 has been shown to be a critical regulator of Th17 pathogenicity. Loss of GPR65 in mice results in a decrease in Th17 cells and reduced susceptibility to a mouse model of multiple sclerosis. The CREB/CRTC2 pathway has emerged as an important reg
Autor:
Kelly A. Remedios, Mark H. Ginsberg, Jane E. Klann, Justine Lopez, Brian G. Petrich, Lauren A. Mack, John T. Chang, Stephanie H. Kim, Ye Zheng, Patrick J. Metz
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 198, iss 12
Talin, a cytoskeletal protein essential in mediating integrin activation, has been previously shown to be involved in the regulation of T cell proliferation and function. In this study, we describe a role for talin in maintaining the homeostasis and
Autor:
Chin San Loo, Ye Zheng
Publikováno v:
The Journal of Immunology. 204:80.4-80.4
Regulatory T cells (Tregs) are a specialized immune population that act to suppress overactive inflammatory response and maintain immune homeostasis. There is of great interest in harnessing Treg for controlling autoimmune disease or boosting anti-tu
Autor:
Soyoung Ha, Dan R. Littman, Brandon N. Nelson, Jingping Lu, Saiyu Hang, Michael A. Fischbach, Jamma Trinath, Michael R. Krout, Donggi Paik, Ye Zheng, Samantha P. Kelly, Lin Wu, Fraydoon Rastinejad, A. Sloan Devlin, Jun R. Huh
Publikováno v:
The Journal of Immunology. 204:230.6-230.6
Bile acids are abundantly present in the mammalian gut, where they undergo bacteria-mediated transformation, generating a large pool of bioactive molecules. While they have been shown to affect host metabolism, cancer progression and innate immunity,
Autor:
Jeniffer B Hernandez, Si Cave, Carl Decker, Jack Swanson, Qiyuan Yang, Ye Zheng, Marc Montminy
Publikováno v:
The Journal of Immunology. 204:76.1-76.1
The cAMP response element-binding (CREB) protein has emerged as an important regulator of immune function. We have previously shown that CREB, along with its co-activator CRTC2, modulates autoimmune disease by promoting differentiation of the pro-inf
Autor:
Chin San Loo, Ye Zheng
Publikováno v:
The Journal of Immunology. 202:128.1-128.1
Forkhead box P3 (Foxp3) is an indispensable transcription factor that controls the development of regulatory T cells (Tregs) and programs their suppressive functions. Understanding the mechanisms that regulate Foxp3 expression can potentially lead to
Autor:
Nidhanjali Bansal, Christina Chang, Yuqiong Liang, Eleen Y. Shum, Jody C. Martin, James Ghadiali, Devon Jensen, Jing Hu, David Rosenfeld, Ye Zheng, H. Christina Fan
Publikováno v:
The Journal of Immunology. 200:120.11-120.11
Diverse immune populations reside in non-lymphoid organs and contribute to immune defense and tissue homeostasis. However, these cells are often hard to study due to low cell abundance and high heterogeneity. Recent advancements in single-cell sequen
Autor:
David L. Owen, Shawn A Mahmud, Jason B Williams, Jonathan C Jeschke, Praful Aggarwal, Ulrich Broeckel, Marisa Alegre, Ye Zheng, Calvin B Williams, Michael A Farrar
Publikováno v:
The Journal of Immunology. 198:215.15-215.15
Mature thymic regulatory T cells (Tregs) are defined by dual expression of Foxp3 and CD25 on CD4SP thymocytes. However, the cellular pathways by which CD4 thymocytes differentiate into Tregs remain incompletely understood. Previous reports demonstrat