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Autor:
Botond Z. Igyártó, Monica Montes, Aurélie Bouteau, Zhiqing Wang, Yves Levy, Sandra Zurawski, Jerome Ellis, Valentina Ceglia, Gerard Zurawski
Publikováno v:
J Immunol
CD40 is a potent activating receptor within the TNFR family expressed on APCs of the immune system, and it regulates many aspects of B and T cell immunity via interaction with CD40 ligand (CD40L; CD154) expressed on the surface of activated T cells.
Autor:
Isuzu Kobayashi, Tatsufumi Goto, Hideki Wakui, Kumi Ubukawa, Ken Asanuma, Yumi Sasaki, Naoto Takahashi, Yong-Mei Guo, Kenichi Sawada
Publikováno v:
The Journal of Immunology. 207:1078-1086
Emergency granulopoiesis, also known as demand-adapted granulopoiesis, is defined as the response of an organism to systemic bacterial infections, and it results in neutrophil mobilization from reservoir pools and increased myelopoiesis in the bone m
Autor:
Yuehan Gao, He Li, Binyao Chen, Wenru Su, Zhaohuai Li, Zhaohao Huang, Yingfeng Zheng, Xianggui Wang, Lihui Xie, Xiuxing Liu, Xianchai Lin
Publikováno v:
The Journal of Immunology. 207:837-848
Dendritic cells (DCs) are critical for pathogen recognition and Ag processing/presentation. Human monocyte-derived DCs (moDCs) have been extensively used in experimental studies and DC-based immunotherapy approaches. However, the extent of human moDC
Publikováno v:
The Journal of Immunology. 206:1681-1689
The original concept stated that immature dendritic cells (DC) act tolerogenically whereas mature DC behave strictly immunogenically. Meanwhile, it is also accepted that phenotypically mature stages of all conventional DC subsets can promote toleranc
Publikováno v:
The Journal of Immunology. 206:1793-1805
In addition to the membrane-bound form, CD154 also exists as a soluble molecule originating from an intracellular and membrane cleavage. We have previously shown that CD154 cleavage from T cell surface is mediated by CD40 and involves the action of A
Autor:
Andrew Appert, Sridhar Rao, Seok Hee Jang, Richard Dahl, Nathan Klopfenstein, William Morgan Hallas, Kirthi Pulakanti, Karen D. Cowden Dahl, Austin Boucher, Jennifer Skibbe
Publikováno v:
J Immunol
Macrophages are critical for regulating inflammatory responses. Environmental signals polarize macrophages to either a proinflammatory (M1) state or an anti-inflammatory (M2) state. We observed that the microRNA (miRNA) cluster mirn23a, coding for mi
Publikováno v:
The Journal of Immunology. 206:257-263
Stromal cells have for a long time been viewed as structural cells that support distinct compartments within lymphoid tissues and little more. Instead, an active cross-talk between endothelial and fibroblastic stromal cells drives the maturation of l
Publikováno v:
J Immunol
Foxo1 is an essential transcription factor required for the survival and differentiation of memory CD8 T cells, yet it is unclear whether these Foxo1-dependent functions are inherently coupled. To address this question, we examined the effects of dif
Autor:
H. Robert Frost, Kristine B. Valenteros, Nicholas K. Preiss, Yasmin Kamal, Young-Kwang Usherwood, Edward J. Usherwood, Yanbo Sun
Publikováno v:
J Immunol
CD8 T cell differentiation is orchestrated by dynamic metabolic changes that direct activation, proliferation, cytotoxic function, and epigenetic changes. We report that the BTB-ZF family transcriptional repressor Zbtb20 negatively regulates CD8 T ce
Publikováno v:
The Journal of Immunology. 205:1909-1919
IL-33 is known to promote type 2 immune responses through ST2, a component of the IL-33R complex, expressed primarily on mast cells, Th2 cells, group 2 innate lymphoid cells and regulatory T cells, and to a lesser extent, on NK cells and Th1 cells. C