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Autor:
Christophe Ferrand, Olivier Adotevi, Emilie Picard, Olivier Mauvais, Jean-René Pallandre, Yann Godet, Nathalie Chaput, John Wijdenes, Guillaume Kellerman, Virginie Mougey, Jeanne Galaine, Christophe Borg, Pedro Romero, Lise Queiroz, Romain Loyon, Patricia Mercier-Letondal
Publikováno v:
The Journal of Immunology. 197:85-96
NK cells are critical for innate immunity–mediated protection. The main roles of NK cells rely on their cytotoxic functions or depend on the tuning of Th1 adaptive immunity by IFN-γ. However, the precise influence of inflammatory cytokines on NK c
Autor:
Kyung-Hyun Park-Min, Celestia Fang, Se Hwan Mun, Lionel B. Ivashkiv, Min Joon Lee, Yu Qiao, Seyeon Bae, Baohong Zhao, Koichi Murata
Publikováno v:
The Journal of Immunology. 196:4452-4456
Osteoclasts are resorptive cells that are important for homeostatic bone remodeling and pathological bone resorption. Emerging evidence suggests an important role for epigenetic mechanisms in osteoclastogenesis. A recent study showed that epigenetic
Autor:
Dafne Franz, Hugo González, Rodrigo Pacheco, Valentina Ugalde, Daniela Elgueta, Francisco Contreras, Carolina Prado, Alvaro Lladser, Alicia Figueroa, Francisco Osorio-Barrios, Ernesto Lopez, Fabiola Osorio
Publikováno v:
The Journal of Immunology. 196:4143-4149
Dopamine receptor D3 (DRD3) expressed on CD4+ T cells is required to promote neuroinflammation in a murine model of Parkinson’s disease. However, how DRD3 signaling affects T cell–mediated immunity remains unknown. In this study, we report that T
Publikováno v:
The Journal of Immunology. 196:3975-3982
The human body is exposed to potentially pathogenic microorganisms at barrier sites such as the skin, lungs, and gastrointestinal tract. To mount an effective response against these pathogens, the immune system must recruit the right cells with effec
Autor:
Ángeles Domínguez-Soto, Concha Nieto, Carmen Sánchez-Torres, Mariana Pacheco-Blanco, Angel L. Corbí, Marco Antonio Meraz-Ríos, José Luis Flores-Sevilla, Miguel A. Vega, Erika González-Domínguez, Victoria Campos-Peña
Publikováno v:
The Journal of Immunology. 196:1327-1337
Human CD14++CD16− and CD14+/loCD16+ monocyte subsets comprise 85 and 15% of blood monocytes, respectively, and are thought to represent distinct stages in the monocyte differentiation pathway. However, the differentiation fates of both monocyte sub
Autor:
Ryoko Morita, Fumiko Hirota, Yasuhiro Mouri, Junko Morimoto, Mitsuru Matsumoto, Hiroshi Kawano, Yasuhiko Nishioka, Hitoshi Nishijima
Publikováno v:
The Journal of Immunology. 195:5149-5158
Aire in medullary thymic epithelial cells (mTECs) plays an important role in the establishment of self-tolerance. Because Aire+ mTECs appear to be a limited subset, they may constitute a unique lineage(s) among mTECs. An alternative possibility is th
Publikováno v:
The Journal of Immunology. 195:2648-2656
Hepatic stellate cells (HSCs) inhibit T cells, a process that could help the liver to maintain its immunoprivileged status. HSCs secrete latent TGF-β1, but the detailed mechanisms by which latent TGF-β1 is activated and whether it plays any role in
Autor:
Alexandra Lainé, Bruno Martin, Cédric Auffray, Georges Bismuth, Marine Luka, Lucile Mir, Céline Charvet, Bruno Lucas
Publikováno v:
The Journal of Immunology. 195:1791-1803
An uncontrolled exaggerated Th17 response can drive the onset of autoimmune and inflammatory diseases. In this study, we show that, in T cells, Foxo1 is a negative regulator of the Th17 program. Using mixed bone marrow chimeras and Foxo1-deficient mi
Autor:
Tohru Ikeda, Ethan M. Shevach, Deborah D. Glass, Amina Metidji, Sadiye Amcaoglu Rieder, Bruce A. Morgan, Angela M. Thornton
Publikováno v:
The Journal of Immunology. 195:553-563
Eos belongs to the Ikaros family of transcription factors. It was reported to be a regulatory T cell (Treg) signature gene, to play a critical role in Treg suppressor functions, and to maintain Treg stability. We used mice with a global deficiency in
Autor:
Marie Le Bras, Thomas Felzmann, Angela Halfmann, Matthias Gaestel, Fiona Poyer, Klara Soukup, Thomas Haider, Sarah Vittori, Gernot Schabbauer, Emine Sahin, Stephan Blüml, Cornelia Schuh, Romana Luger, Alexey Kotlyarov, Birgit Niederreiter, Dagmar Stoiber, Alexander M. Dohnal
Publikováno v:
The Journal of Immunology. 195:541-552
Dendritic cell (DC)–mediated inflammation induced via TLRs is promoted by MAPK-activated protein kinase (MK)-2, a substrate of p38 MAPK. In this study we show an opposing role of MK2, by which it consolidates immune regulatory functions in DCs thro