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Autor:
Andrew Appert, Sridhar Rao, Seok Hee Jang, Richard Dahl, Nathan Klopfenstein, William Morgan Hallas, Kirthi Pulakanti, Karen D. Cowden Dahl, Austin Boucher, Jennifer Skibbe
Publikováno v:
J Immunol
Macrophages are critical for regulating inflammatory responses. Environmental signals polarize macrophages to either a proinflammatory (M1) state or an anti-inflammatory (M2) state. We observed that the microRNA (miRNA) cluster mirn23a, coding for mi
Publikováno v:
J Immunol
Foxo1 is an essential transcription factor required for the survival and differentiation of memory CD8 T cells, yet it is unclear whether these Foxo1-dependent functions are inherently coupled. To address this question, we examined the effects of dif
Autor:
H. Robert Frost, Kristine B. Valenteros, Nicholas K. Preiss, Yasmin Kamal, Young-Kwang Usherwood, Edward J. Usherwood, Yanbo Sun
Publikováno v:
J Immunol
CD8 T cell differentiation is orchestrated by dynamic metabolic changes that direct activation, proliferation, cytotoxic function, and epigenetic changes. We report that the BTB-ZF family transcriptional repressor Zbtb20 negatively regulates CD8 T ce
Publikováno v:
The Journal of Immunology. 205:1909-1919
IL-33 is known to promote type 2 immune responses through ST2, a component of the IL-33R complex, expressed primarily on mast cells, Th2 cells, group 2 innate lymphoid cells and regulatory T cells, and to a lesser extent, on NK cells and Th1 cells. C
Autor:
Todd M. Brusko, Michael V. Wiles, David V. Serreze, Cheng Ye, Benjamin E. Low, John P. Driver
Publikováno v:
J Immunol
The CD27–CD70 costimulatory pathway is essential for the full activation of T cells, but some studies show that blocking this pathway exacerbates certain autoimmune disorders. In this study, we report on the impact of CD27–CD70 signaling on disea
Autor:
Jessy Presumey, Matthew B. Johnson, Steffen Thiel, Beth Stevens, Heidi Gytz Olesen, Esra Yalcin, Annette G. Hansen, Alessandra Zarantonello, Lea Simoni, Gregers R. Andersen, Nick S. Laursen, Michael C. Carroll, Rachel Fox
Publikováno v:
Zarantonello, A, Presumey, J, Simoni, L, Yalcin, E, Fox, R, Hansen, A, Olesen, H G, Thiel, S, Johnson, M B, Stevens, B, Laursen, N S, Carroll, M C & Andersen, G R 2020, ' An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase ', Journal of Immunology, vol. 205, no. 6, pp. 1678-1694 . https://doi.org/10.4049/jimmunol.2000528
The classical and lectin pathways of the complement system are important for the elimination of pathogens and apoptotic cells and stimulation of the adaptive immune system. Upon activation of these pathways, complement component C4 is proteolytically
Publikováno v:
The Journal of Immunology. 204:3400-3415
Mixed-lineage leukemia 1 (MLL1), which exerts its H3K4 methyltransferase activity by interacting with WDR5, ASH2L, and RBBP5, plays a pivotal role in regulating hematopoietic stem cell homeostasis. Disrupting the integrity of MLL1-complex has been re
Autor:
Maria Metsger, Eloise Scamardella, Valentina Serra, Elena Tenedini, Alexey N. Davydov, Emilia Maria Cristina Mazza, Karolina Pilipow, Alessandra Roberto, Francesco Ferrari, Joshua M. Farber, Domenico Mavilio, Clelia Peano, David Price, Veronica Zanon, Federico Colombo, Federica Sallusto, Gabriele De Simone, Edoardo Fiorillo, Antonino Cassotta, Dmitriy M. Chudakov, Matteo Iannacone, Enrico Tagliafico, Luca Gattinoni, Valeria Orrù, Enrico Lugli, Federica De Paoli, Mirela Kuka, Satya P. Singh, Francesco Cucca
Publikováno v:
The Journal of Immunology
The Journal of Immunology Author Choice
The Journal of Immunology Author Choice
Key Points CXCR3 identifies human naive CD8+ T cells with biased effector potential. Human naive CD8+ T cell subsets are functionally and transcriptionally distinct. Effector potential correlates with the physicochemical attributes of expressed TCRs.
Autor:
Brian J. Lee, Shan Zha, Zhengping Shao, Verna M Estes, Jennifer L. Crowe, Xiaobin S Wang, Wenxia Jiang, Xiaohui Lin
Publikováno v:
J Immunol
The classical nonhomologous end-joining (cNHEJ) pathway is a major DNA double-strand break repair pathway in mammalian cells and is required for lymphocyte development and maturation. The DNA-dependent protein kinase (DNA-PK) is a cNHEJ factor that e
Autor:
Véronique Laplante, Mukut Sharma, Sarah Pasquin, Andreea Milasan, Gaétan Mayer, Aurélie Jeanne Tormo, Catherine Martel, Shiriane Kouadri, Virginia J. Savin, Jean-François Gauchat
Publikováno v:
The Journal of Immunology. 201:2462-2471
CLCF1 is a neurotrophic and B cell–stimulating factor belonging to the IL-6 family. Mutations in the gene coding for CLCF1 or its secretion partner CRLF1 lead to the development of severe phenotypes, suggesting important nonredundant roles in devel