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Autor:
Petra Reinke, Lisa Rollins, Michael Schmueck-Henneresse, Natalia Lapteva, Sandhya Sharma, Gianpietro Dotti, Thomas Shum, Maksim Mamonkin, Bilal Omer, Haruko Tashiro, Cliona M. Rooney, Hans-Dieter Volk
Publikováno v:
The Journal of Immunology. 199:348-362
The outcome of therapy with chimeric Ag receptor (CAR)-modified T cells is strongly influenced by the subset origin of the infused T cells. However, because polyclonally activated T cells acquire a largely CD45RO+CCR7− effector memory phenotype aft
Autor:
Christophe Ferrand, Olivier Adotevi, Emilie Picard, Olivier Mauvais, Jean-René Pallandre, Yann Godet, Nathalie Chaput, John Wijdenes, Guillaume Kellerman, Virginie Mougey, Jeanne Galaine, Christophe Borg, Pedro Romero, Lise Queiroz, Romain Loyon, Patricia Mercier-Letondal
Publikováno v:
The Journal of Immunology. 197:85-96
NK cells are critical for innate immunity–mediated protection. The main roles of NK cells rely on their cytotoxic functions or depend on the tuning of Th1 adaptive immunity by IFN-γ. However, the precise influence of inflammatory cytokines on NK c
Autor:
Dafne Franz, Hugo González, Rodrigo Pacheco, Valentina Ugalde, Daniela Elgueta, Francisco Contreras, Carolina Prado, Alvaro Lladser, Alicia Figueroa, Francisco Osorio-Barrios, Ernesto Lopez, Fabiola Osorio
Publikováno v:
The Journal of Immunology. 196:4143-4149
Dopamine receptor D3 (DRD3) expressed on CD4+ T cells is required to promote neuroinflammation in a murine model of Parkinson’s disease. However, how DRD3 signaling affects T cell–mediated immunity remains unknown. In this study, we report that T
Autor:
Jae Il Lee, Seong Hoe Park, Hye In Yum, Eun Bong Lee, Byung Hyun Kang, Kyeong Cheon Jung, Chung Gyu Park, Eun Ha Kang, Hyo Jin Park, Jin Kyun Park, Seung Pyo Park
Publikováno v:
The Journal of Immunology. 194:5861-5871
Identification of intrathymic eomesodermin+ (Eomes+) CD4 T cells creates a novel idea that there is more than one way for the generation of innate CD4 T cells. Promyelocytic leukemia zinc finger protein+ T cells and natural Th17 cells are known to be
Autor:
Ali Gawanbacht, Christof Kaltenmeier, Ramin Lotfi, Georg Härter, Manfred Hönig, Klaus Schwarz, Peter Kern, Timo Trzaska, Beate Grüner, Frank Kirchhoff, Hubert Schrezenmeier, Dorit Fabricius, Bernd Jahrsdörfer, Stefanie Lindner, Johannes A. van der Merwe, Catharina Schütz, Thamara Beyer, Ansgar Schulz, Martin Bommer
Publikováno v:
The Journal of Immunology. 194:3768-3777
IL-21 can induce both plasma cells and regulatory B cells. In this article, we demonstrate that untreated HIV patients display CD4+ T cells with enhanced IL-21 expression and high in vivo frequencies of regulatory B cells overexpressing the serine pr
Autor:
Bruce R. Blazar, Todd Lenvik, Julie M. Curtsinger, Bree Foley, Dave Ankarlo, Xianghua Luo, Stephen K. Anderson, Martin Felices, Jeffrey S. Miller
Publikováno v:
The Journal of Immunology. 192:3889-3897
Acquisition of a functional NK cell repertoire, known as education or licensing, is a complex process mediated through inhibitory receptors that recognize self. We found that NK cells containing self-killer Ig-like receptors for cognate HLA ligand in
Autor:
Yoichiro Kusunoki, Lauren F. Young, Kengo Yoshida, Marcel R.M. van den Brink, Yoshiko Kubo, Junko Kajimura, Kei Nakachi, Tomonori Hayashi, Kazue Imai, Seishi Kyoizumi, Malcolm A.S. Moore
Publikováno v:
The Journal of Immunology. 190:6164-6172
Age-associated changes of T and NK cell (T/NK) potential of human hematopoietic stem cells are unknown. In this study, we enumerate and characterize T/NK precursors among CD34+Lin− cell populations circulating in normal human adult peripheral blood
Autor:
Andrew T. Lacek, Tamson V. Moore, David J. Cole, José A. Guevara-Patiño, Michael C. Jagoda, Jeremy A. O'Sullivan, Frederick J. Kohlhapp, James McCracken, Andrew Zloza
Publikováno v:
The Journal of Immunology. 188:3639-3647
CD8+ T cell responses have been shown to be regulated by dendritic cells (DCs) and CD4+ T cells, leading to the tenet that CD8+ T cells play a passive role in their own differentiation. In contrast, by using a DNA vaccination model, to separate the e
Autor:
Janani Sivakumaran, Stephen Mackinnon, May Sabry, Robert H. Anderson, Konstantinos Giannopoulos, Janet North, Maria Tsirogianni, Ismail Bakhsh, Mark W. Lowdell
Publikováno v:
The Journal of Immunology. 187:6227-6234
Resting human NK cells require a two-stage activation process that we have previously described as “priming” and “triggering.” NK-sensitive tumor cells provide both priming and triggering signals. NK-resistant tumors evade lysis, mostly by fa
Autor:
Diletta Di Mitri, Natalie E. Riddell, Richard Macaulay, Luca Battistini, Sian M. Henson, Valentina Libri, David Glyn Kipling, Arne N. Akbar, Rita I. Azevedo, Maria V. D. Soares
Publikováno v:
The Journal of Immunology. 187:2093-2100
Persistent viral infections and inflammatory syndromes induce the accumulation of T cells with characteristics of terminal differentiation or senescence. However, the mechanism that regulates the end-stage differentiation of these cells is unclear. H