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Autor:
Marika Kangasniemi, Kaisu Luiro, Oskari Heikinheimo, Terhi Piltonen, Riikka K Arffman, Elina K Komsi, Juha S. Tapanainen, J. Kalervo Hiltunen, Annina Haverinen
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:e2483-e2490
Context Combined oral contraceptives (COCs) alter inflammatory status and lipid metabolism. Whether different estrogens have different effects is poorly understood. Objective We compared the effects of COCs containing ethinyl estradiol (EE) or estrad
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 104:5148-5156
Context Medroxyprogesterone acetate (MPA) is a widely used progestin in feminizing hormone therapy. However, the side effects and hormonal changes elicited by this drug have never been investigated in the transgender population. Objective We evaluate
Autor:
Arthi Thirumalai, Lori A. Cooper, Stephanie T. Page, Daniel W. Lin, Katya B. Rubinow, Alvin M. Matsumoto, Jonathan L. Wright, Brett T. Marck, John K. Amory
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 101:2937-2944
Concern exists that T replacement therapy (TRT) might increase the risk of prostate disease. There are limited data regarding the impact of TRT on prostate androgen concentrations.Determine the dose-dependent effects of exogenous T administration on
Autor:
Sath Nag, Simon H. S. Pearce, Shu Chen, S. M. A. Bennett, Bijay Vaidya, Phil King, John D. Isaacs, Bernard Rees Smith, Sukesh Chandran, Anna L. Mitchell
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:E1927-E1932
Context: A diagnosis of Addison's disease means lifelong dependence on daily glucocorticoid and mineralocorticoid therapy and is associated with increased morbidity and mortality as well as a risk of unexpected adrenal crisis. Objective: The objectiv
Autor:
Claudio Ferri, Alexander W. Krug, Benjamin A. Raby, Bindu Chamarthi, Jonathan S. Williams, Bei Sun, Paul N. Hopkins, Gordon H. Williams, Jessica Lasky-Su, Xavier Jeunemaitre
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:E1825-E1829
Both aldosterone and cortisol can activate the mineralocorticoid receptor (MR). Polymorphisms in the MR gene have been inconsistently shown to be associated with risk of hypertension and aldosterone and cortisol levels. The purpose of this project wa
Autor:
Richard D. Gordon, Gregory Ward, Eduardo Pimenta, Paul J. Taylor, Ashraf H. Ahmed, Michael Stowasser
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:1797-1804
The most popular screening test for primary aldosteronism is plasma aldosterone/renin ratio (ARR). Because both estrogen and progesterone affect aldosterone and renin levels, we studied effects of two contraceptives commonly used in our population, o
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 95:E300-E309
Context: Retinoic acid (RA) controls multiple biological processes via exerting opposing effects on cell survival. Retinol uptake into cells is controlled by stimulated by RA 6 (STRA6). RA is then produced from retinol in the cytosol. Partitioning of
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 94:4810-4819
Due to the natural progression of type 2 diabetes (T2D), most patients require combination therapy to maintain glycemic control.Our objective was to evaluate efficacy and safety of saxagliptin plus thiazolidinedione (TZD) in patients with T2D and ina
Autor:
Anna-Lena Eriksson, Fernand Labrie, Alain Bélanger, Anders Rane, Claes Ohlsson, Liesbeth Vandenput, Jenny Jakobsson, Östen Ljunggren, Dan Mellström, Magnus Karlsson, Mattias Lorentzon, Charlotte Swanson, Ulf Smith
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:4878-4882
Context: Previous in vitro studies have demonstrated that the UDP glucuronosyltransferase (UGT)2B15 and UGT2B17 glucuronidate androgens and their metabolites. Objective: Our objective was to determine in vivo whether the UGT2B15 D85Y and the UGT2B17
Autor:
A. Millet, E. Torres, F. Escobar-Jiménez, E. López, Joaquim Calaf, Fortuny A, Juan José Espinós, Justo Callejo, J. Alcañiz, O. Vidal
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:3446-3452
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; OBJECTIVE Our objective was to test the efficacy and tolerability of three doses of flutamide (125, 250, and 375 mg) combined with a triphasic oral contraceptive (ethynyl