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Autor:
Jing Qian, Aakriti Gupta, Eunyoung Kim, Wei He, Joyce Yan, Tanayott Thaweethai, James B. Meigs, Heidi Lumish, Andrea S. Foulkes, Steven A. Lubitz, Virginia A. Triant, Daniel J Shinnick, David Cheng, Caitlin A. Selvaggi, Muredach P. Reilly, Tingyi Cao, Ingrid V. Bassett, Kevin J. Clerkin, Mahesh V. Madhavan, Frances Lu
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Background Obesity is an established risk factor for severe COVID-19 outcomes. The mechanistic underpinnings of this association are not well-understood. Objective To evaluate the mediating role of systemic inflammation in obesity-associated COVID-19
Autor:
Miriam A. Bredella, Madhusmita Misra
Publikováno v:
J Clin Endocrinol Metab
Purpose The prevalence of childhood obesity has increased over past decades with a concomitant increase in metabolic and bariatric surgery (MBS). While MBS in adults is associated with bone loss, only a few studies have examined the effect of MBS on
Publikováno v:
J Clin Endocrinol Metab
Maturity-onset diabetes of the young, or MODY-monogenic diabetes, is a not-so-rare collection of inherited disorders of non-autoimmune diabetes mellitus that remains insufficiently diagnosed despite increasing awareness. These cases are important to
Autor:
Jeffrey D Zajac, Ada S Cheung, Sav Zwickl, Teddy Cook, Hui Yin Lim, Ariel Ginger, Cherie Chiang
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context As the number of transgender (trans) people (including those who are binary and/or nonbinary identified) seeking gender-affirming hormone therapy rises, endocrinologists are increasingly asked to assist with interpretation of laboratory tests
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context Approximately 60% of adults harbor 1 or more thyroid nodules. The possibility of cancer is the overriding concern, but only about 5% prove to be malignant. The widespread use of diagnostic imaging and improved access to health care favor the
Autor:
Nicolette C. Bishop, Carl J. Hulston, Alexander J. Wadley, Rachel M Woods, Rebecca Dewhurst-Trigg, Lauren B. Sherar, Oonagh Markey
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:2162-2176
Context It is unclear how white adipose tissue (WAT) inflammatory signaling proteins respond during the early stages of overnutrition. Objective To investigate the effect of short-term, high-fat overfeeding on fasting abdominal subcutaneous WAT total
Autor:
Richard D. Gordon, Karen Young, A. H. Ahmed, Moe Thuzar, Michael Stowasser, Greg Ward, Jacobus P.J. Ungerer, Zeng Guo, Brett McWhinney, Martin Wolley
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:e477-e483
Background In primary aldosteronism (PA), excessive, autonomous secretion of aldosterone is not suppressed by salt loading or fludrocortisone. For seated saline suppression testing (SSST), the recommended diagnostic cutoff 4-hour plasma aldosterone c
Autor:
Bernard Zinman, Luke W. Johnston, Ravi Retnakaran, Zhila Semnani-Azad, Stewart B. Harris, Anthony J. Hanley, Philip W. Connelly
Publikováno v:
Semnani-Azad, Z, Connelly, P W, Johnston, L W, Retnakaran, R, Harris, S B, Zinman, B & Hanley, A J 2020, ' The Macrophage Activation Marker Soluble CD163 is Longitudinally Associated With Insulin Sensitivity and β-cell Function ', The Journal of clinical endocrinology and metabolism, vol. 105, no. 3 . https://doi.org/10.1210/clinem/dgz166
J Clin Endocrinol Metab
J Clin Endocrinol Metab
Context Chronic inflammation arising from adipose tissue macrophage (ATM) activation may be central in type 2 diabetes etiology. Our objective was to assess the longitudinal associations of soluble CD163 (sCD163), a novel biomarker of ATM activation,
Autor:
Gerrit van Hall, Thomas Idorn, Bo Feldt-Rasmussen, Iain Bressendorff, Bolette Hartmann, Casper Rydahl, Nicolai J. Wewer Albrechtsen, Lisbet Brandi, Jens J. Holst, Henrik Post Hansen, Morten B. Jørgensen, Mads Hornum, Filip K. Knop
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:e564-e574
Context The insulin-stimulating and glucagon-regulating effects of the 2 incretin hormones, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), contribute to maintain normal glucose homeostasis. Impaired glucose to
Autor:
Annette Masuch, Anna Artati, Henry Völzke, Wolfgang Rathmann, Jerzy Adamski, Maik Pietzner, Thomas Kocher, Nele Friedrich, Kathrin Budde, Charlotte Wildberg, Matthias Nauck, Gabi Kastenmüller
Publikováno v:
J. Clin. Endocrinol. Metab. 104, 6357-6370 (2019)
Objective Impaired glucose tolerance (IGT) is one of the presymptomatic states of type 2 diabetes mellitus and requires an oral glucose tolerance test (OGTT) for diagnosis. Our aims were twofold: (i) characterize signatures of small molecules predict