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Autor:
Elizabeth Stambrook, David A. D'Alessio, Martin Bidlingmaier, Harold W. Davis, Juliane Ramisch, Matthias H. Tschöp, Jenny Tong
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:3366-3374
The 20-kDa human GH (hGH) is produced in the pituitary by alternative splicing of the hGH-N gene. The 20-kDa hGH promotes growth similarly to 22-kDa or total hGH, the predominant form in circulation, but the relative effects of these isoforms on gluc
Autor:
Nicholas J. Wareham, Burak Salgin, Ajay Thankamony, David B. Dunger, Ken K. Ong, Pauline M Emmett
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:3302-3309
There are limited data in humans on the association between fasting free fatty acid (FFA) levels and pancreatic β-cell function.Our objective was to examine this association in children and adults with normal glucose tolerance and to explore fasting
Autor:
Desmond G. Johnston, Ian F. Godsland, Jimmy D. Bell, Darrell V. Pavitt, Stanislas X. Morin, E. Louise Thomas, Simon D. Taylor-Robinson, Sanjeev R. Mehta
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:2151-2159
Context: Insulin is pivotal in regulating hepatic lipid synthesis, metabolism, and export. Objective: We tested the hypothesis that intrahepatic insulin exposure is an important determinant of intrahepatocellular lipid (IHCL), taking into account reg
Autor:
Kelly L. McCoy, Kenneth J. Smith, Sally E. Carty, Linwah Yip, Steven P. Hodak, Adam S. Kabaker, Michael T. Stang, Coreen Farris, Marina N. Nikiforova, Yuri E. Nikiforov
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Introduction: Molecular testing of fine-needle aspiration (FNA) results helps diagnose thyroid cancer, although the additional cost of this adjunct has not been studied. We hypothesized that FNA molecular testing of two indeterminate categories (foll
Autor:
Kai Sun, Olga D. Carlson, Luigi Ferrucci, Candace Crasto, Josephine M. Egan, Richard D. Semba
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:1375-1382
Context: The relationship of fibroblast growth factor 21 (FGF21) with glucose metabolism and insulin resistance has not been well characterized in community-dwelling adults. Objective: The objective of the study was to examine the relationship of FGF
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:1363-1370
The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophy
Autor:
Lynne E. Wagenknecht, Andreas Festa, Anthony J. Hanley, Nels C. Olson, Russell P. Tracy, Peter W. Callas, Steven M. Haffner
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:1032-1040
Although several epidemiological studies have investigated associations between TNF-α and insulin resistance, results have been inconsistent. We studied the relationship between TNF-α and glucose tolerance status as part of the Insulin Resistance A
Autor:
Thierry Delbot, Alain Chevalier, Marie Bienvenu-Perrard, Caroline Pichard de Malleray, Lionel Groussin, Jérôme Clerc, Robert J. Marlowe, Françoise Aubène Leger, F. Dagousset, Marc Dreyfuss
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:871-880
In low-risk differentiated thyroid cancer (DTC), postoperative (131)I remnant ablation should employ a minimum effective activity; reports increasingly suggest efficacy of low activities, e.g. 1110 MBq/30 mCi. OBJECTIVES, DESIGN, PATIENTS, AND INTERV
Autor:
Oliver Blankenstein, Khalid Hussain, Michael Ashworth, Sarah E. Flanagan, Sian Ellard, Virpi V. Smith, Ritika R. Kapoor, Dunia Ismail, Agostino Pierro
Publikováno v:
J Clin Endocrinol Metab
BACKGROUND: Congenital hyperinsulinism (CHI) is a cause of persistent hypoglycemia due to unregulated insulin secretion from pancreatic β-cells. Histologically, there are two major subgroups, focal and diffuse. Focal CHI is typically unresponsive to
Autor:
Kitt Falk Petersen, Sylvie Dufour
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:3873-3880
Low birth weight (LBW) is a marker of fetal stress and is associated with an increased prevalence of type 2 diabetes (T2D). Insulin resistance plays a prominent role in the development of T2D; however, the pathogenesis of T2D in LBW is controversial.