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Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:824-830
The very low GH concentration in obesity is commonly attributed to high body fat mass; however, the influence of overeating on GH secretion is not clear.The aim of the study was to examine the effects of 2 wk of overeating on changes in GH secretion.
Autor:
Niels Møller, Steen B. Pedersen, Jens Otto Lunde Jørgensen, Ole Schmitz, Sten Lund, Mikkel H. Vendelbo, Lars C. Gormsen, Niels Jessen
Publikováno v:
Vendelbo, M, Jørgensen, J O, Pedersen, S B, Gormsen, L C, Lund, S, Schmitz, O, Jessen, N & Møller, N 2010, ' Exercise and Fasting Activate Growth Hormone-Dependent Myocellular Signal Transducer and Activator of Transcription-5b Phosphorylation and Insulin-Like Growth Factor-I Messenger Ribonucleic Acid Expression in Humans ', Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 9, pp. E64-68 . https://doi.org/10.1210/jc.2010-0689
Udgivelsesdato: 2010-Jun-9 Context: GH secretion is increased by stress, such as fasting and exercise. Objective: Our study was designed to test the hypothesis that fasting and exercise increase GH levels, GH-dependent signal transducer and activator
Autor:
Mohamad Maghnie, Sandro Loche, Costanza Frassinetti, Natascia Di Iorgi, Stefano Parodi, Maria Rosaria Casini, Flavia Napoli, Michele Ghezzi, Renata Lorini, Erika Calandra, Andrea Secco
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 94:4251-4257
Few studies have addressed the diagnostic role of the glucagon test in children with suspected GH deficiency (GHD).The objective of the study was to investigate the diagnostic value of the glucagon test as an alternative test to insulin tolerance tes
Autor:
Matthew P. Harber, Naila Goldenberg, Jeffrey F. Horowitz, Kathy Symons, Sowmya Surya, Ariel L. Barkan, Alla A. Sakharova
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:2755-2759
Context: Fasting is associated with suppressed insulin and augmented GH secretion. The involvement of each mechanism in the regulation of fuel mobilization during fasting is unknown. Objective: To ascertain the role of GH in the regulation of the rat
Autor:
Steven B. Heymsfield, Carlos Reyes-Vidal, Dympna Gallagher, Pamela U. Freda, Wei Shen, Eliza B. Geer, Jeffrey N. Bruce
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:2334-2343
Context: GH and IGF-I are important regulators of metabolism and body composition. In acromegaly, a state of GH and IGF-I excess, the lipolytic and insulin antagonistic effects of GH may alter adipose tissue (AT) distribution. Objectives: Our objecti
Autor:
E. Vilaró, Cristina Esteban, Maria Clemente, P. Andaluz, Diego Yeste, M. Gussinyé, A. Carrascosa, Mónica Fernández-Cancio, M. A. Albisu, Laura Audi
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:764-770
Consensus is lacking as to whether the exon 3-deleted (d3)/full-length (fl) GH receptor (GHR) polymorphism is associated with responsiveness to GH therapy.Our objective was to evaluate, in short, prepubertal, appropriate-for-gestational age (AGA) pat
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:4265-4270
GH replacement in GH-deficient adults results in an improvement in metabolic status. GH might also decrease visceral adiposity in obese adults that are not GH deficient.Our objective was to determine the effects of supraphysiological GH therapy on th
Autor:
Valdir Ambrósio Moisés, Julio Abucham, Turibio L. Barros-Neto, Manoel Ricardo Alves Martins, Fabio Luiz Casanova Doin, William Ricardo Komatsu
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:4144-4153
The biological significance of GH-induced changes in serum TH concentrations is unknown. It has been suggested that serum free T(4) (FT(4)) should be targeted at the high-normal range during GH replacement.Our objective was to evaluate the effects of
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 92(8), 2992-3000. Endocrine Society
Context: IGF-I plays an important role in pre- and postnatal growth. Its serum levels are regulated by metabolic and genetic factors. Mean total IGF-I in short, small for gestational age (SGA) children is reduced, but within the normal range. Free/di
Autor:
Farideh Miraki-Moud, K. T. Maher, Leonila A. Kalingag, D. M. Walker, Joy P. Hinson, Cecilia Camacho-Hübner, Antonia M. Brooke, John P. Monson
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:3773-3779
Context: Patients with panhypopituitarism have impaired quality of life (QoL) despite GH replacement. They are profoundly androgen deficient, and dehydroepiandrosterone (DHEA) has been shown to have a beneficial effect on well-being and mood in patie