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of 156
pro vyhledávání: ''
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:824-830
The very low GH concentration in obesity is commonly attributed to high body fat mass; however, the influence of overeating on GH secretion is not clear.The aim of the study was to examine the effects of 2 wk of overeating on changes in GH secretion.
Autor:
Mohamad Maghnie, Sandro Loche, Costanza Frassinetti, Natascia Di Iorgi, Stefano Parodi, Maria Rosaria Casini, Flavia Napoli, Michele Ghezzi, Renata Lorini, Erika Calandra, Andrea Secco
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 94:4251-4257
Few studies have addressed the diagnostic role of the glucagon test in children with suspected GH deficiency (GHD).The objective of the study was to investigate the diagnostic value of the glucagon test as an alternative test to insulin tolerance tes
Autor:
Steven B. Heymsfield, Carlos Reyes-Vidal, Dympna Gallagher, Pamela U. Freda, Wei Shen, Eliza B. Geer, Jeffrey N. Bruce
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:2334-2343
Context: GH and IGF-I are important regulators of metabolism and body composition. In acromegaly, a state of GH and IGF-I excess, the lipolytic and insulin antagonistic effects of GH may alter adipose tissue (AT) distribution. Objectives: Our objecti
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:4265-4270
GH replacement in GH-deficient adults results in an improvement in metabolic status. GH might also decrease visceral adiposity in obese adults that are not GH deficient.Our objective was to determine the effects of supraphysiological GH therapy on th
Autor:
Valdir Ambrósio Moisés, Julio Abucham, Turibio L. Barros-Neto, Manoel Ricardo Alves Martins, Fabio Luiz Casanova Doin, William Ricardo Komatsu
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:4144-4153
The biological significance of GH-induced changes in serum TH concentrations is unknown. It has been suggested that serum free T(4) (FT(4)) should be targeted at the high-normal range during GH replacement.Our objective was to evaluate the effects of
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 92(8), 2992-3000. Endocrine Society
Context: IGF-I plays an important role in pre- and postnatal growth. Its serum levels are regulated by metabolic and genetic factors. Mean total IGF-I in short, small for gestational age (SGA) children is reduced, but within the normal range. Free/di
Autor:
Farideh Miraki-Moud, K. T. Maher, Leonila A. Kalingag, D. M. Walker, Joy P. Hinson, Cecilia Camacho-Hübner, Antonia M. Brooke, John P. Monson
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:3773-3779
Context: Patients with panhypopituitarism have impaired quality of life (QoL) despite GH replacement. They are profoundly androgen deficient, and dehydroepiandrosterone (DHEA) has been shown to have a beneficial effect on well-being and mood in patie
Autor:
Juergen Kratzsch, S. Laue, Eberhard Keller, Robert J. Smith, Wieland Kiess, Klemens Raile, A. Keller, Anke Schneider, Jürgen Klammt, Roland Pfäffle
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:2264-2271
Signaling via the IGF-I receptor (IGF-IR) is crucial for normal prenatal and postnatal growth. The heterozygous IGF-IR mutation Arg59Ter resulted in reduced IGF-IR expression and represents haploinsufficiency of the human IGF1R gene.We studied clinic
Autor:
Stephen M Shalet, Amanda Ogilvy-Stuart, Rachel Stoeter, Bernadette Brennan, Helena Gleeson, H. R. Gattamaneni
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 88:3682-3689
Final height (FH) outcome is important in survivors of childhood brain tumors. GH replacement is indicated in those found to be GH deficient (GHD). More recently, GnRH analogs (GnRHa) have been introduced to delay early or rapidly progressing puberty
Autor:
Paul G.H. Mulder, Maarten Reeser, Anita Hokken-Koelega, Mieke Houdijk, Yvonne van Pareren, M. Jansen
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 88(1), 347-353. Endocrine Society
Hyperlipidemia, diabetes mellitus type 2, and coronary heart disease have been associated with being born small for gestational age (SGA). It has been reported that GH treatment induced higher insulin levels, which has led to concern regarding the lo