Zobrazeno 1 - 10
of 25
pro vyhledávání: ''
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:824-830
The very low GH concentration in obesity is commonly attributed to high body fat mass; however, the influence of overeating on GH secretion is not clear.The aim of the study was to examine the effects of 2 wk of overeating on changes in GH secretion.
Autor:
Matthew P. Harber, Naila Goldenberg, Jeffrey F. Horowitz, Kathy Symons, Sowmya Surya, Ariel L. Barkan, Alla A. Sakharova
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:2755-2759
Context: Fasting is associated with suppressed insulin and augmented GH secretion. The involvement of each mechanism in the regulation of fuel mobilization during fasting is unknown. Objective: To ascertain the role of GH in the regulation of the rat
Autor:
E. Vilaró, Cristina Esteban, Maria Clemente, P. Andaluz, Diego Yeste, M. Gussinyé, A. Carrascosa, Mónica Fernández-Cancio, M. A. Albisu, Laura Audi
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:764-770
Consensus is lacking as to whether the exon 3-deleted (d3)/full-length (fl) GH receptor (GHR) polymorphism is associated with responsiveness to GH therapy.Our objective was to evaluate, in short, prepubertal, appropriate-for-gestational age (AGA) pat
Autor:
Valdir Ambrósio Moisés, Julio Abucham, Turibio L. Barros-Neto, Manoel Ricardo Alves Martins, Fabio Luiz Casanova Doin, William Ricardo Komatsu
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:4144-4153
The biological significance of GH-induced changes in serum TH concentrations is unknown. It has been suggested that serum free T(4) (FT(4)) should be targeted at the high-normal range during GH replacement.Our objective was to evaluate the effects of
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 92(8), 2992-3000. Endocrine Society
Context: IGF-I plays an important role in pre- and postnatal growth. Its serum levels are regulated by metabolic and genetic factors. Mean total IGF-I in short, small for gestational age (SGA) children is reduced, but within the normal range. Free/di
Autor:
Kerstin Albertsson-Wikland, Patrick Wilton, Michael B. Ranke, David A. Price, Edward O. Reiter
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:2047-2054
Treatment with GH has been used to correct the growth deficit in children with GH deficiency (GHD). Although successful in increasing height velocity, such treatment often falls short of helping patients achieve full genetic height potential.This stu
Autor:
Ronald S. Swerdloff, Xiao-Dan Qu, Daniel F. Kelly, Mohammed Y. Al Sayed, Irene T. Gaw Gonzalo, Pejman Cohan, Peter D. Christenson, Christina Wang
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 90:1563-1569
The aim of this study is to assess whether gender and body mass index (BMI) should be considered in developing thresholds to define GH deficiency, using GH responses to GHRH + arginine (ARG) stimulation and insulin tolerance test (ITT). Thirty-nine h
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 89:1285-1290
The present study tests the postulate that testosterone (Te) stimulates GH secretion, in part, by attenuating autonegative feedback. To this end, 13 healthy men (ages 43-71 yr) received three consecutive weekly im injections of placebo (Pl) (n = 7) o
Autor:
Johannes D. Veldhuis, Mark Patterson, Judy Y. Weltman, Laurie Wideman, James T. Patrie, Arthur Weltman
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 89:840-846
GH represses its own secretion via rapid and reversible feedback exerted at key hypothalamic loci. The primary mechanisms include stimulation of somatostatin release and inhibition of GHRH outflow. Autoinhibition is prominent in the adult male rat bu
Autor:
Jens Otto Lunde Jørgensen, Jan Frystyk, K. Sreekumaran Nair, Per Ivarsen, Steen Nielsen, Helene Nørrelund, Jens Sandahl Christiansen, Niels Møller
Publikováno v:
Aarhus University
Nørrelund, H, Nair, K S, Nielsen, S, Frystyk, J, Ivarsen, P, Jørgensen, J O L, Christiansen, J S & Møller, N 2003, ' The decisive role of free fatty acids for protein conservation during fasting in humans with and without growth hormone ', Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 9, pp. 4371-4378 .
Nørrelund, H, Nair, K S, Nielsen, S, Frystyk, J, Ivarsen, P, Jørgensen, J O L, Christiansen, J S & Møller, N 2003, ' The decisive role of free fatty acids for protein conservation during fasting in humans with and without growth hormone ', Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 9, pp. 4371-4378 .
During fasting, a lack of GH increases protein loss by close to 50%, but the underlying mechanisms remain uncertain. The present study tests the hypothesis that the anabolic actions of GH depend on mobilization of lipids. Seven normal subjects were e