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Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:1870-1878
Autoimmune thyroid diseases (AITDs) can be associated with type 1 diabetes (DM1). The prevalence of serum antibodies against thyroid hormones (THAb) in subjects with autoimmune diseases other than DM1 is increasing. No data are available for DM1.The
Autor:
Muhammad A. Abdul-Ghani, Ralph A. DeFronzo, Aurora Merovci, Scheherezada Urban McCarthy, Andrea Mari, Devjit Tripathy, Carolina Solis, Giuseppe Daniele, Juan Xiong, Alberto Chavez-Velazquez
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:1927-1932
Background: β-Cell dysfunction is a core defect in T2DM, and chronic, sustained hyperglycemia has been implicated in progressive β-cell failure, ie, glucotoxicity. The aim of the present study was to examine the effect of lowering the plasma glucos
Autor:
Charles Faiman, Betul Hatipoglu, Rita Bottino, Philip C. Johnston, James Bena, Yu Kuei Lin, Tyler Stevens, R. Matthew Walsh, Massimo Trucco
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:1765-1770
Context: Total pancreatectomy (TP) with islet cell autotransplantation (IAT) can reduce or prevent diabetes by preserving beta cell function and is normally performed with on-site isolation laboratory facilities. Objective: We examined factors associ
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:1602-1608
Context: Epidemiologic studies suggest that endogenous testosterone (T) levels in males may be implicated in cardiovascular disease (CVD), however further clarification is needed. Objective: We assessed the cross-sectional relationship between endoge
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:1078-1087
Increased adiposity and insulin resistance are associated with hyperglycemia and previous studies have reported that higher glucoses are associated with lower rates of weight gain. One possible mechanism is via increased energy expenditure (EE).To as
Autor:
Lynne E. Wagenknecht, Nicholette D. Palmer, Richard N. Bergman, Peter A. Antinozzi, Andrea Anderson, Robert Stevens, Donald W. Bowden, Christopher B. Newgard
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:E463-E468
Metabolomic profiling of amino acids and acylcarnitines has revealed consistent patterns associated with metabolic disease.This study used metabolomic profiling to identify analytes associated with insulin sensitivity (SI) and conversion to type 2 di
Autor:
Ksenia Sevastianova, Marju Orho-Melander, Hannele Yki-Järvinen, Nina Lundbom, Per-Henrik Groop, Sanja Sädevirta, Carol Forsblom, Gemma Llauradó, Antti Hakkarainen
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:607-616
Patients with type 1 diabetes mellitus (T1DM) lack the portal/peripheral insulin gradient, which might diminish insulin stimulation of hepatic lipogenesis and protect against development of nonalcoholic fatty liver disease (NAFLD). We compared liver
Autor:
Balakumar Swaminathan, Mathew Sermer, Caroline K. Kramer, Anthony J. Hanley, Ravi Retnakaran, Philip W. Connelly, Bernard Zinman
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 99:4506-4513
Context: Previous studies have yielded conflicting findings on the relationship between vitamin D deficiency/insufficiency and gestational diabetes mellitus (GDM). We hypothesized that PTH may be an underlying factor relevant to this potential associ
Autor:
Anke Tönjes, Juergen Kratzsch, Thomas Ebert, Anne Hoffmann, Susan Kralisch, Matthias Blüher, Mathias Fasshauer, Anette Bachmann, Ulrike Lossner, Michael Stumvoll
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 99:E2510-E2517
Angiopoietin-like protein 8 (Angptl8) has recently been introduced as a novel adipokine/hepatokine that promotes pancreatic β-cell proliferation and improves glucose tolerance in mouse models of insulin resistance. However, regulation of Angptl8 in
Autor:
Ian F. Godsland, Ali Alsafi, Rachel C. Troke, Victoria Salem, Mandy Donaldson, Mohammad A. Ghatei, Kevin C.R. Baynes, James Minnion, Benjamin C. T. Field, Stephen R. Bloom, Tricia Tan, Akila De Silva, Shivani Misra
Publikováno v:
E2324
E2317
The Journal of Clinical Endocrinology and Metabolism
E2317
The Journal of Clinical Endocrinology and Metabolism
Context: The combination of peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) has been proposed as a potential treatment for diabetes and obesity. However, the combined effects of these hormones, PYY3–36 and GLP-17–36 amide, on glucose homeost