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Autor:
Kai Sun, Olga D. Carlson, Luigi Ferrucci, Candace Crasto, Josephine M. Egan, Richard D. Semba
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:1375-1382
Context: The relationship of fibroblast growth factor 21 (FGF21) with glucose metabolism and insulin resistance has not been well characterized in community-dwelling adults. Objective: The objective of the study was to examine the relationship of FGF
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:1363-1370
The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophy
Autor:
Lynne E. Wagenknecht, Andreas Festa, Anthony J. Hanley, Nels C. Olson, Russell P. Tracy, Peter W. Callas, Steven M. Haffner
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:1032-1040
Although several epidemiological studies have investigated associations between TNF-α and insulin resistance, results have been inconsistent. We studied the relationship between TNF-α and glucose tolerance status as part of the Insulin Resistance A
Autor:
Samuel Dagogo-Jack, James T. Lane
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:3289-3297
New-onset diabetes after transplantation (NODAT) refers to the occurrence of diabetes in previously nondiabetic persons after organ transplantation. The incidence rates of NODAT vary by organ transplanted and posttransplant interval. The estimated ra
Autor:
Vipul Periwal, Amber B. Courville, Gyorgy Csako, Anne E. Sumner, Gloria Lena Vega, Carson C. Chow, Bernard V. Miller, Madia Ricks
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:2456-2463
Obesity and diabetes are more common in African-Americans than whites. Because free fatty acids (FFA) participate in the development of these conditions, studying race differences in the regulation of FFA and glucose by insulin is essential.The objec
Roux-en-Y Gastric Bypass Corrects Hyperinsulinemia Implications for the Remission of Type 2 Diabetes
Autor:
Rita C. Bowden, Timothy P. Gavin, William C. Chapman, Melissa A. Reed, G. Lynis Dohm, Hisham A. Barakat, Steven P. Piccoli, Walter J. Pories, Donghai Zheng, David Polidori, Lynn Yieh, Leona Brenner-Gati, Ed Tapscott, Nigel P. Shankley, Thomas D. Green, John R. Pender
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:2525-2531
Roux-en-Y gastric bypass (RYGB) has been shown to induce rapid and durable reversal of type 2 diabetes.The aim of the study was to investigate a possible mechanism for the remission of type 2 diabetes after RYGB.A cross-sectional, nonrandomized, cont
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:2136-2145
In epidemiological studies of childhood obesity, simple and reliable surrogate estimates of insulin sensitivity are needed because the gold standard, the hyperinsulinemic-euglycemic clamp, is not feasible on a large scale.To examine the correlation o
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:E1083-E1091
Maternal obesity, gestational diabetes (GDM), or type 2 diabetes (T2DM) is associated with altered lipid metabolism and fetal overgrowth.The objective of the study was to test the hypothesis that hyperlipidemia and hyperinsulinemia regulate lipid con
Age at Menarche and Metabolic Markers for Type 2 Diabetes in Premenopausal Women: The BioCycle Study
Autor:
Cuilin Zhang, Liwei Chen, Edwina Yeung, Enrique F. Schisterman, Aijun Ye, Jean Wactawski-Wende, Sunni L. Mumford
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:E1007-E1012
Early age at menarche has been linked to an elevated risk of type 2 diabetes. However, the underlying mechanism is unclear.Our objective was to examine associations between age at menarche and type 2 diabetes risk factors.The BioCycle Study followed
Autor:
Islam N. Mohamed, Paresh Dandona, Antoine Makdissi, Sandeep Dhindsa, Sonny Dandona, Husam Ghanim, Chang Ling Sia, Ajay Chaudhuri
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:1783-1788
Our objective was to determine whether peripheral blood mononuclear cells express amyloid precursor protein (APP) and other mediators involved in the pathogenesis of Alzheimer's disease and whether their expression is suppressed by insulin.Ten obese