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Autor:
Andreas Peter, Hans-Ulrich Häring, Martin Heni, Corinna Dannecker, Norbert Stefan, Andreas L. Birkenfeld, Julia Hummel, Robert Wagner, Andreas Vosseler, Andreas Fritsche
Publikováno v:
J. Clin. Endocrinol. Metab. 106, 1576-1584 (2021)
The Journal of Clinical Endocrinology and Metabolism
The Journal of Clinical Endocrinology and Metabolism
Context Pharmacological lowering of low-density lipoprotein (LDL) cholesterol potently reduces cardiovascular risk while concurrently increasing type 2 diabetes risk. Objective The aim of this study was to investigate the relationship between LDL cho
Autor:
Jack C M Ng, C. Mary Schooling
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:e2778-e2788
Context Glucagon acts reciprocally with insulin to regular blood glucose. However, the effect of glucagon on cardiovascular disease has not been widely studied. It has been suggested that insulin may increase the risk of ischemic heart disease. Objec
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 103:1522-1529
CONTEXT: Total pancreatectomy and intrahepatic islet autotransplantation (TP/IAT) is performed to alleviate severe abdominal pain, avoid narcotic use, maintain islet function, and avoid diabetes in patients with chronic pancreatitis. However, many TP
Autor:
Tanya J. Little, Laurence G. Trahair, Carolyn F. Deacon, Karen L. Jones, Michelle J. Bound, Michael Horowitz, Xiang Zhang, Christopher K. Rayner, Tongzhi Wu
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 101:4769-4778
Context: The rate of gastric emptying is an important determinant of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) secretion and may influence the magnitude of glucose lowering by dipeptidyl peptidase-4 (DPP-4
Autor:
Vikash Dadlani, Ananda Basu, Jennifer R. Geske, Adil E. Bharucha, Michele Schiavon, Rickey E. Carter, Claudio Cobelli, Ling Hinshaw, Rita Basu, Ashwini Mallad, Chiara Dalla Man, Yogish C. Kudva
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 101:1954-1962
Context: Early postprandial hyperglycemia and delayed hypoglycemia remain major problems in current management of type 1 diabetes (T1D). Objective: Our objective was to investigate the effects of pramlintide, known to suppress glucagon and delay gast
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:2987-2995
Hyperglucagonemia is a characteristic feature of type 2 diabetes (T2DM) that has been postulated to be due to β-cell dysfunction and the resultant loss of insulin-mediated α-cell suppression. When administered in early T2DM, short-term intensive in
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 99:1733-1740
The objective of the study was to clarify the relative contribution of islet number and islet size to β- and α-cell mass in humans.We obtained the pancreas at autopsy from 72 Japanese adults with no history of diabetes or pancreatitis (aged 47 ± 1
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:1363-1370
The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophy
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:1450-1455
Recent studies in mice have demonstrated that insulin signaling in osteoblasts stimulates bone formation and reduces osteoprotegerin production; the latter results in an increase in bone resorption, which then leads to the release of undercarboxylate
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:185-191
Type 2 diabetes mellitus (T2DM) is estimated to account for 10-45% of incident pediatric diabetes cases.Our objective was to characterize the metabolic defects underlying T2DM in adolescents and young adults.We conducted a cross-sectional study of is