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Autor:
Meagan Gray, Charles M. Rowland, Michael J. McPhaul, Kenneth Cusi, Dov Shiffman, Romina Lomonaco, Srilaxmi Kalavalapalli, Fernando Bril, Diana Barb
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 106:e4360-e4371
Context Patients with nonalcoholic fatty liver disease (NAFLD) are characterized by insulin resistance and hyperinsulinism. However, insulin resistance measurements have not been shown to be good diagnostic tools to predict NAFLD in prior studies. Ob
Autor:
Navin Michael, Zhiling Chan, Cherlyn Ding, Melvin Khee-Shing Leow, Yu Chung Chooi, Faidon Magkos, S. Sendhil Velan, Suresh Anand Sadananthan, John Choo
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 104:127-136
Context - The prevalence of diabetes is increasing throughout Asia, even in the absence of obesity, and is lower in women than in men. The underlying mechanisms are not well understood. Objective - To evaluate the sex differences in glucose and fatty
Autor:
Kristen J. Nadeau, Brandy M. Ringham, Melanie Cree-Green, Bradley R. Newcomer, Dana Dabelea, Ninghe Cai, Laura Pyle, Mark S. Brown
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 102:1652-1660
Context: Obesity, insulin resistance (IR), and diabetes are increasing in youth, especially in girls. IR is associated with muscle mitochondrial dysfunction in youth and adults with diabetes. However, it is unknown whether this relationship is presen
Autor:
Melanie Cree-Green, Daniel H. Bessesen, Kristen J. Nadeau, Teresa A. Sharp, Megan M. Kelsey, Laura Pyle, Rebecca A. Ohman-Hanson, Rocio I. Pereira
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 101:4808-4815
Insulin resistance (IR) and type 2 diabetes are increasing, particularly in Hispanic (H) vs non-Hispanic White (NHW) populations. Adiponectin has a known role in IR, and therefore, understanding ethnic and sex-specific behavior of adiponectin across
Autor:
Angela Sciacqua, Giorgio Sesti, Teresa Vanessa Fiorentino, Maria Perticone, Gaia Chiara Mannino, Elisabetta Pedace, Francesco Perticone, Francesco Andreozzi
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 101:4030-4038
Individuals with glycated hemoglobin (HbA1c)-defined prediabetes (HbA1c value of 5.7-6.4%) and 1-hour plasma glucose ≥155 mg/dL during an oral glucose tolerance test have an increased risk of developing type 2 diabetes.To evaluate the degree to whi
Autor:
G. William Wong, Leigh A. Peterson, Thomas H. Magnuson, Michael Schweitzer, Risa M. Wolf, Kimberley E. Steele, Xiange Zeng, Andrew E. Jaffe
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 101:2211-2217
Context: C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that has beneficial metabolic and cardiovascular effects in various animal models. Alterations in circulating CTRP9 have also been observed in patients with cardiovascular disease and di
Autor:
Brent S. Abel, Ahmed M. Gharib, Katherine P. Mullins, Ranganath Muniyappa, Monica C. Skarulis, Mary Walter, Ronald Ouwerkerk, Ritu Madan, Radwa A Noureldin, Elizabeth Y. Liu
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:3060-3068
Background: Myocardial steatosis, an independent predictor of diastolic dysfunction, is frequently present in type 2 diabetes mellitus. High free fatty acid flux, hyperglycemia, and hyperinsulinemia may play a role in myocardial steatosis. There are
Autor:
Pier Maria Battezzati, Carla Colombo, L. Zazzeron, Simona Bertoli, Andrea Mari, Giorgio Bedogni, Gianfranco Alicandro, Alberto Battezzati
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:2963-2971
Cystic fibrosis (CF) causes an exceptionally high prevalence of diabetes that increases with age, especially in females. The glucose tolerance defect is progressive, but a cystic fibrosis transmembrane conductance regulator-dependent insulin secretor
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:1602-1608
Context: Epidemiologic studies suggest that endogenous testosterone (T) levels in males may be implicated in cardiovascular disease (CVD), however further clarification is needed. Objective: We assessed the cross-sectional relationship between endoge
Autor:
Anke Tönjes, Juergen Kratzsch, Thomas Ebert, Anne Hoffmann, Susan Kralisch, Matthias Blüher, Mathias Fasshauer, Anette Bachmann, Ulrike Lossner, Michael Stumvoll
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 99:E2510-E2517
Angiopoietin-like protein 8 (Angptl8) has recently been introduced as a novel adipokine/hepatokine that promotes pancreatic β-cell proliferation and improves glucose tolerance in mouse models of insulin resistance. However, regulation of Angptl8 in