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Autor:
Pier Maria Battezzati, Carla Colombo, L. Zazzeron, Simona Bertoli, Andrea Mari, Giorgio Bedogni, Gianfranco Alicandro, Alberto Battezzati
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:2963-2971
Cystic fibrosis (CF) causes an exceptionally high prevalence of diabetes that increases with age, especially in females. The glucose tolerance defect is progressive, but a cystic fibrosis transmembrane conductance regulator-dependent insulin secretor
Autor:
Muhammad A. Abdul-Ghani, Ralph A. DeFronzo, Aurora Merovci, Scheherezada Urban McCarthy, Andrea Mari, Devjit Tripathy, Carolina Solis, Giuseppe Daniele, Juan Xiong, Alberto Chavez-Velazquez
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:1927-1932
Background: β-Cell dysfunction is a core defect in T2DM, and chronic, sustained hyperglycemia has been implicated in progressive β-cell failure, ie, glucotoxicity. The aim of the present study was to examine the effect of lowering the plasma glucos
Autor:
Barbara A. Gower, Norman K. Pollock, Thomas L. Clemens, Laura Lee Goree, Wesley M. Granger, Krista Casazza
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Animal studies indicate that osteocalcin (OC), particularly the undercarboxylated isoform (unOC), affects insulin sensitivity and secretion, but definitive data from humans are lacking.The objectives of the study were to determine whether total OC an
Autor:
Desmond G. Johnston, Ian F. Godsland, Jimmy D. Bell, Darrell V. Pavitt, Stanislas X. Morin, E. Louise Thomas, Simon D. Taylor-Robinson, Sanjeev R. Mehta
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:2151-2159
Context: Insulin is pivotal in regulating hepatic lipid synthesis, metabolism, and export. Objective: We tested the hypothesis that intrahepatic insulin exposure is an important determinant of intrahepatocellular lipid (IHCL), taking into account reg
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:1363-1370
The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophy
Autor:
K. Sreekumaran Nair, Kevin R. Short, Andrea Tom, Maureen L. Bigelow, Katherine A. Klaus, Brian A. Irving, L.L. Tatpati
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 95:894-902
Context: A reduction in maximal mitochondrial ATP production rate (MAPR) and mitochondrial DNA (mtDNA) abundance occurs with age in association with muscle weakness and reduced endurance in elderly people. Branched chain amino acids (BCAA) have been
Autor:
Kerstin Kirchhoff, Axel Haupt, Silke A. Schäfer, Norbert Stefan, Harald Staiger, Andreas Fritsche, Baptist Gallwitz, Fausto Machicao, Hans-Ulrich Häring, Martina Guthoff
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 94:1775-1780
Recently novel type 2 diabetes risk loci were identified and reported to associate with beta-cell dysfunction. We assessed whether the risk alleles in TCF7L2, CDKAL1, HHEX, SLC30A8, IGF2BP2, CDKN2A/2B, JAZF1, and WFS1 reduce insulin secretion in an a
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:1778-1784
Our aim was to assess the effect of chronic hyperglycemia on glucose- and insulin-mediated suppression of glucagon secretion by the alpha-cell.Thirty subjects with normal glucose tolerance, 27 with impaired fasting glucose and/or impaired glucose tol
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:93-97
Women of Asian and South Asian descent are at increased risk of developing gestational diabetes mellitus compared with Caucasians, despite lower body mass index (BMI). Nevertheless, there has been limited study of insulin action during pregnancy in t
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:185-191
Type 2 diabetes mellitus (T2DM) is estimated to account for 10-45% of incident pediatric diabetes cases.Our objective was to characterize the metabolic defects underlying T2DM in adolescents and young adults.We conducted a cross-sectional study of is