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Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:824-830
The very low GH concentration in obesity is commonly attributed to high body fat mass; however, the influence of overeating on GH secretion is not clear.The aim of the study was to examine the effects of 2 wk of overeating on changes in GH secretion.
Autor:
Mohamad Maghnie, Sandro Loche, Costanza Frassinetti, Natascia Di Iorgi, Stefano Parodi, Maria Rosaria Casini, Flavia Napoli, Michele Ghezzi, Renata Lorini, Erika Calandra, Andrea Secco
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 94:4251-4257
Few studies have addressed the diagnostic role of the glucagon test in children with suspected GH deficiency (GHD).The objective of the study was to investigate the diagnostic value of the glucagon test as an alternative test to insulin tolerance tes
Autor:
Steven B. Heymsfield, Carlos Reyes-Vidal, Dympna Gallagher, Pamela U. Freda, Wei Shen, Eliza B. Geer, Jeffrey N. Bruce
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:2334-2343
Context: GH and IGF-I are important regulators of metabolism and body composition. In acromegaly, a state of GH and IGF-I excess, the lipolytic and insulin antagonistic effects of GH may alter adipose tissue (AT) distribution. Objectives: Our objecti
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:4265-4270
GH replacement in GH-deficient adults results in an improvement in metabolic status. GH might also decrease visceral adiposity in obese adults that are not GH deficient.Our objective was to determine the effects of supraphysiological GH therapy on th
Autor:
Valdir Ambrósio Moisés, Julio Abucham, Turibio L. Barros-Neto, Manoel Ricardo Alves Martins, Fabio Luiz Casanova Doin, William Ricardo Komatsu
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:4144-4153
The biological significance of GH-induced changes in serum TH concentrations is unknown. It has been suggested that serum free T(4) (FT(4)) should be targeted at the high-normal range during GH replacement.Our objective was to evaluate the effects of
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 92(8), 2992-3000. Endocrine Society
Context: IGF-I plays an important role in pre- and postnatal growth. Its serum levels are regulated by metabolic and genetic factors. Mean total IGF-I in short, small for gestational age (SGA) children is reduced, but within the normal range. Free/di
Autor:
Farideh Miraki-Moud, K. T. Maher, Leonila A. Kalingag, D. M. Walker, Joy P. Hinson, Cecilia Camacho-Hübner, Antonia M. Brooke, John P. Monson
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:3773-3779
Context: Patients with panhypopituitarism have impaired quality of life (QoL) despite GH replacement. They are profoundly androgen deficient, and dehydroepiandrosterone (DHEA) has been shown to have a beneficial effect on well-being and mood in patie
Autor:
Kerstin Albertsson-Wikland, Patrick Wilton, Michael B. Ranke, David A. Price, Edward O. Reiter
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:2047-2054
Treatment with GH has been used to correct the growth deficit in children with GH deficiency (GHD). Although successful in increasing height velocity, such treatment often falls short of helping patients achieve full genetic height potential.This stu
Autor:
Ronald S. Swerdloff, Xiao-Dan Qu, Daniel F. Kelly, Mohammed Y. Al Sayed, Irene T. Gaw Gonzalo, Pejman Cohan, Peter D. Christenson, Christina Wang
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 90:1563-1569
The aim of this study is to assess whether gender and body mass index (BMI) should be considered in developing thresholds to define GH deficiency, using GH responses to GHRH + arginine (ARG) stimulation and insulin tolerance test (ITT). Thirty-nine h
Autor:
Johannes D. Veldhuis, Mark Patterson, Judy Y. Weltman, Laurie Wideman, James T. Patrie, Arthur Weltman
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 89:840-846
GH represses its own secretion via rapid and reversible feedback exerted at key hypothalamic loci. The primary mechanisms include stimulation of somatostatin release and inhibition of GHRH outflow. Autoinhibition is prominent in the adult male rat bu