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Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:E1225-E1233
Roux-en-Y gastric bypass (RYGB) is the most effective treatment for morbid obesity and resolution of diabetes. Over the last decade, it has become well accepted that this resolution of diabetes occurs before significant weight loss; however, the mech
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 95:1986-1990
Context: Aldosterone production is associated with insulin resistance in obese and hypertensive subjects. However, its effect on insulin sensitivity in healthy subjects is not clear. Objective: The objective of this study was to test the hypothesis t
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 94:4136-4143
Hormone therapy (HT) increases the risk of venous thrombosis and stroke. Risk of venous thrombosis and stroke is higher in older, overweight, and obese women using HT. However, the impact of age and obesity on estrogen concentrations among HT users i
Autor:
Akira Shimada, Tetsuro Kobayashi, Taro Maruyama, Azuma Kanatsuka, Osamu Funae, Hiroki Shimura, Norikazu Harii, Shoichiro Tanaka, Izumi Takei, Akira Kasuga, Satoru Yamada
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:2115-2121
Objective: We tested the hypothesis that insulin therapy rather than sulfonylurea (SU) treatment is preferable to reverse or preserve β-cell function among patients with slowly progressive insulin-dependent (type 1) diabetes (SPIDDM) or latent autoi
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:131-138
Postmenopausal hormone therapy has been examined extensively in relation to cardiovascular disease. However, research relating serum levels of sex hormones to cardiovascular disease is sparse, and the results are inconclusive.We measured sex hormones
Autor:
Frank Z. Stanczyk, Eric Vittinghoff, Bruce Ettinger, Walt Chandler, Mitch Dowsett, Jim Settlage, Deborah Grady, Elizabeth Folkerd, Jane A. Cauley, Vladimir Hanes, Jennifer Lee, Steven R. Cummings, Mary S. Beattie
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:3791-3797
Accurate measurement of low serum estradiol (E(2)30 pg/ml or110 pmol/liter) is needed to study relationships between endogenous E(2) and risks of diseases in older women.The objective of this study was to determine whether an extraction-based (indire
Autor:
Timothy G. Lesnick, Shu C. Foong, David H. Abbott, Daniel A. Dumesic, Jennifer L. Phy, Michael A. Zschunke
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:2327-2333
Polycystic ovary syndrome (PCOS) is a reproductive disorder of ovarian hyperandrogenism and insulin resistance characterized by abnormal luteinization of small follicles. After exposure to GnRH analog/FSH stimulation for in vitro fertilization (IVF),
Autor:
R. Jeffrey Chang, Richard Y. Yoo, Christine A. Eagleson, John C. Marshall, Kathleen A. Prendergast, Sandhya Chhabra, Carol M. Foster, Christopher R. McCartney
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:1714-1722
Context: Adolescent hyperandrogenemia is considered a forerunner of adult polycystic ovary syndrome, but its etiology remains uncertain. Objective: Our objective was to explore the hypothesis that peripubertal obesity is associated with hyperandrogen
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:1015-1020
Context: Lower systolic blood pressure (SBP) and lower rates of coronary heart disease among premenopausal women compared with similarly aged men and postmenopausal women suggest that female sex hormones may confer cardiovascular protection. 2-Hydrox
Autor:
M. Javad Hosseinzadeh Attar, Gerard S. Conway, E. Louise Thomas, Gavin Hamilton, Julia E. Ostberg, Jimmy D. Bell
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 90:2631-2635
Obesity, predominantly centrally distributed, is common in women with Turner syndrome (TS) and is thought to contribute to the increased risk of atherosclerosis; however, insulin concentrations are unexpectedly low. To explore this discrepancy, we as