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pro vyhledávání: ''
Autor:
Tiphaine Vidal-Trecan, B. Blondeau, Véronique Tardy-Guidollet, Jean-Pierre Riveline, Baz Baz, Sabrina Fetita, Philippe Boudou, Fidaa Ibrahim, Yves Morel, J.-L. Nguewa, Eric Vicaut, Aude Brac de la Perriere, Jean-François Gautier, Bernadette Breant
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:e191-e199
Objective High glucocorticoid levels in rodents inhibit development of beta cells during fetal life and lead to insulin deficiency in adulthood. To test whether similar phenomena occur in humans, we compared beta-cell function in adults who were expo
Autor:
Amy D Anderson, Karen L Knudsen, Christopher R. McCartney, Jessicah S. Collins, James T. Patrie, Eleanor G Hutchens, John C. Marshall, Christine M. Burt Solorzano
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 103:2571-2582
ContextPeripubertal obesity is associated with variable hyperandrogenemia, but precise mechanisms remain unclear.ObjectiveTo assess insulin resistance, hyperinsulinemia, and LH roles in peripubertal obesity–associated hyperandrogenemia.DesignCross-
Autor:
Dorit Samocha-Bonet, Anne Poljak, Donald J. Chisholm, Jerry R. Greenfield, Carsten Liess, Christian Thoma, Aimin Xu, Arthur B. Jenkins, B Milner, Jialiang Zhang, Daniel L. T Chen, Michael I. Trenell
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:4082-4091
Context: Whereas insulin resistance and obesity coexist, some obese individuals remain insulin sensitive. Objective: We examined phenotypic and metabolic factors associated with insulin sensitivity in both muscle and liver in obese individuals. Desig
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 98:4702-4708
Impairment of the incretin effect is one of the hallmarks of type 2 diabetes mellitus (T2DM). However, it is unknown whether this abnormality is specific to incretin-stimulated insulin secretion or a manifestation of generalized β-cell dysfunction.
Autor:
Cristina Lara-Castro, Meera Penumetcha, Bradford G. Hill, Douglas R. Moellering, Bradley R. Newcomer, Helliner S. Hill, Christopher P. Ingalls, Katherine H. Ingram, W. Timothy Garvey, Jeffrey C. Rupp, L. Jerome Brandon
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:E1182-E1186
Objective: The relationships among skeletal muscle lipid peroxidation, intramyocellular lipid content (IMCL), and insulin sensitivity were evaluated in nine insulin-sensitive (IS), 13 insulin-resistant (IR), and 10 adults with type 2 diabetes (T2DM).
Autor:
Bryan C. Bergman, Leigh Perreault, Janet K. Snell-Bergeon, Marian Rewers, David J. Howard, Robert H. Eckel, Irene E. Schauer, David M. Maahs
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:1663-1672
Type 1 diabetes is known to be a state of insulin resistance; however, the tissues involved in whole-body insulin resistance are less well known. It is unclear whether insulin resistance is due to glucose toxicity in the post-Diabetes Control and Com
Autor:
Jan Frystyk, Joachim Spranger, Martin O. Weickert, Andreas Pfeiffer, Ayman M. Arafat, Matthias Möhlig, Christof Schöfl
Publikováno v:
Arafat, A M, Weickert, M O, Frystyk, J, Spranger, J, Schöfl, C, Möhlig, M & Pfeiffer, A F H 2009, ' The Role of Insulin-Like Growth Factor (IGF) Binding Protein-2 in the Insulin-Mediated Decrease in IGF-I Bioactivity ', Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 12, pp. 5093-5101 . https://doi.org/10.1210/jc.2009-0875
Context: Insulin interacts with the GH-IGF system by a reciprocal regulation of IGF-binding proteins (IGFBP) and GH, which in turn regulate insulin sensitivity via bioactive IGF-I. This network is linked to metabolic syndrome and cardiovascular disea
Autor:
Lieuwe de Haan, Hans P. Sauerwein, Therese van Amelsvoort, Mireille J. Serlie, Hiske E. Becker, Regje M. E. Blümer, Lonneke van Nimwegen, Mariëtte T. Ackermans, Eric Fliers, Jitschak G. Storosum, Henk W. Venema, Gideon Allick
Publikováno v:
Journal of clinical endocrinology and metabolism, 93(2), 572-577. The Endocrine Society
OBJECTIVE: Our objective was to measure insulin sensitivity and body composition in antipsychotic-naive patients with DSM IV schizophrenia and/or schizoaffective disorder compared with matched controls. DESIGN: Seven antipsychotic medication-naive pa
Autor:
Oswald Wagner, Peter Nowotny, Jelena Todoric, Michael Krebs, Martin G. Bischof, Anton Luger, Harald Esterbauer, Miriam Promintzer, Christian Anderwald
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:4306-4312
Context: Recent data suggest that circulating retinol-binding protein (RBP) might be involved in the pathogenesis of insulin resistance. Moreover, protein C inhibitor (PCI), which specifically binds retinoic acid, was found to be increased in myocard
Autor:
Sheila Patel, Carmine Giuseppe FANELLI, Ljiljana Lukic, Aleksandra Jotic, Mary Paula Colgan, Andrea Natali, Caterina Guidone, SYMEON TOURNIS, Kurt Højlund, Nebojsa Lalic, Christian Heinz Anderwald, Joost Dekker, Amalia Gastaldelli, Elza Muscelli, Geltrude Mingrone
Publikováno v:
Ferrannini, E, Balkau, B, Coppack, S W, Dekker, J M, Mari, A, Nolan, J, Walker, M, Natali, A, Beck-Nielsen, H & Investigators, RISC 2007, ' Insulin resistance, insulin response, and obesity as indicators of metabolic risk ', Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 8, pp. 2885-92 . https://doi.org/10.1210/jc.2007-0334
Udgivelsesdato: 2007-Aug CONTEXT: Insulin resistance (IR) and obesity, especially abdominal obesity, are regarded as central pathophysiological features of a cluster of cardiovascular risk factors (CVRFs), but their relative roles remain undefined. M