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Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 96:824-830
The very low GH concentration in obesity is commonly attributed to high body fat mass; however, the influence of overeating on GH secretion is not clear.The aim of the study was to examine the effects of 2 wk of overeating on changes in GH secretion.
Autor:
Mohamad Maghnie, Sandro Loche, Costanza Frassinetti, Natascia Di Iorgi, Stefano Parodi, Maria Rosaria Casini, Flavia Napoli, Michele Ghezzi, Renata Lorini, Erika Calandra, Andrea Secco
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 94:4251-4257
Few studies have addressed the diagnostic role of the glucagon test in children with suspected GH deficiency (GHD).The objective of the study was to investigate the diagnostic value of the glucagon test as an alternative test to insulin tolerance tes
Autor:
Catherine Pienkowski, Audrey Cartault, N. Lounis, Pierre Moulin, Catherine Arnaud, Maithé Tauber, Corinne Marcouyeux, Philippe Otal, Isabelle Oliver, Béatrice Jouret, P Rochiccioli, Francis Joffre, Michèle Gayrard
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 88:5101-5106
It is now a consensus to resume GH treatment in adolescents with severe GH deficiency (GHD) at retesting to prevent the occurrence of adult GHD syndrome. However, we do not have any data on the follow-up of adolescents with nonsevere GHD at completio
Autor:
David M. Cook, Pierre Chatelain, Sandra Husbands, Linda Fryklund, Ken K. Ong, Ron G. Rosenfeld, Peter D. Gluckman, David B. Dunger, John Wass, Kevin C.J. Yuen, Michael B. Ranke
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 87:1989-1995
GH has both diabetogenic and insulin-like actions. Supraphysiological GH doses are known to reduce insulin sensitivity (S(I)), but lower doses are less well studied. We therefore compared the effects of two physiological GH doses (intermediate, 0.003
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 86:5813-5818
To test the hypothesis that GH-induced insulin resistance is mediated by an increase in FFA levels we assessed insulin sensitivity after inhibiting the increase in FFA by a nicotine acid derivative, Acipimox, in nine GH-deficient adults receiving GH
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, 102(3), 983-991. Endocrine Society
Children with Silver-Russell syndrome (SRS) are born small for gestational age (SGA) and remain short. Growth hormone (GH) treatment improves height in short SGA children, including those with SRS. Data on metabolic health and long-term safety of GH
Autor:
M Farmer, Michael O. Thorner, M A Bach, E. Van Cauter, Johannes D. Veldhuis, Emily H. Skiles, Suzan S. Pezzoli, G J Gormley, K Y Cole, L M Schilling, A M Taylor, D A Krupa, Ian Chapman, Mark L. Hartman
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 81:4249-4257
Aging is associated with declining activity of the GH axis, possibly contributing to adverse body composition changes and increased incidence of cardiovascular disease. The stimulatory effects on the GH-insulin-like growth factor I (IGF-I) axis of or
Autor:
S. S. C. Yen, Gail A. Laughlin
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 81:4301-4309
Growing evidence suggests that menstrual disturbances in female athletes are related to the metabolic cost of high levels of energy expenditure without compensatory increases in dietary intake. However, the linkage(s) between nutritional deficits and
Autor:
Brendan T. Kinsley, Donald C. Simonson
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 81:684-691
The epinephrine and cortisol responses to hypoglycemia are reduced in insulin-dependent diabetes mellitus (IDDM) patients in strict glycemic control. However, it is not known whether these abnormalities are mediated at a central (hypothalamic-pituita
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 80:2966-2973
Recently, we reported that hyperandrogenism in adolescent girls is accompanied by augmented LH pulsatility and elevated LH/FSH ratio with increased ovarian volume. Together with higher concentrations of 17-hydroxyprogesterone, androstenedione, testos