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Autor:
Sharon E. Oberfield, Ricardo Azziz, Svetlana Ten, Denis A. Magoffin, Soren Harnois-Leblanc, Ethel Codner, Christianne J. Lane, Jean-Patrice Baillargeon, Michael I. Goran, Maria Isabel Hernandez, Fernando Cassorla, David H Geller, Natasha I. Leibel, Revi P. Mathew
Publikováno v:
J Clin Endocrinol Metab
Context First-degree relatives of women with polycystic ovary syndrome (PCOS) present hormonal and metabolic alterations compared to girls unrelated to PCOS. It is unknown whether glucose intolerance in the PCOS proband confers a more severe metaboli
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:1140-1158
Context Preterm birth (PTB) and suboptimal prepregnancy body mass index (BMI) operate through inflammatory pathways to impair fetoplacental development. Placental efflux transporters mediate fetal protection and nutrition; however, few studies consid
Patients With Cirrhosis Have Elevated Bone Turnover but Normal Hepatic Production of Osteoprotegerin
Autor:
Niklas Rye Jørgensen, Søren Møller, Karen Vagner Danielsen, Gitte Lund Christensen, Nina Kimer, Sarah Seberg Diemar
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:e980-e995
Context Severe osteodystrophy is common in patients with liver dysfunction. Markers of bone metabolism may help in early diagnosis of osteodystrophy and in understanding underlying pathophysiological mechanisms. Objective To elucidate changes in bone
Autor:
Zentaro Kiuchi, Harald Jüppner, Patrick Hanna, Robert C. Olney, Peter J. Tebben, Terry DeClue, Monica Reyes, Anu Sharma
Publikováno v:
J Clin Endocrinol Metab
Context Maternally inherited STX16 deletions that cause loss of methylation at GNAS exon A/B and thereby reduce Gsα expression are the most frequent cause of autosomal dominant pseudohypoparathyroidism type Ib (AD-PHP1B). Early identification of the
Autor:
Anne Tybjærg-Hansen, Malene Kongsgaard Hansen, Pia R. Kamstrup, Børge G. Nordestgaard, Henning Bundgaard, Ann Tabor, Ruth Frikke-Schmidt, Sofie Taageby Nielsen, Nina Strandkjær, Kasper Iversen
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:324-335
Background and Objective High lipoprotein(a) is a genetically determined causal risk factor for cardiovascular disease, and 20% of the adult population has high levels (ie, >42 mg/dL, >88 nmol/L). We investigated whether early life lipoprotein(a) lev
Autor:
Sheerazed Boulkroun, Maria-Christina Zennaro, Tchao Meatchi, Kelly De Sousa, Alaa B Abdellatif, Fabio L. Fernandes-Rosa, Laurence Amar, Isabelle Giscos-Douriez
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:419-434
Context Aldosterone-producing adenomas (APAs) are a common cause of primary aldosteronism (PA). Despite the discovery of somatic mutations in APA and the characterization of multiple factors regulating adrenal differentiation and function, the sequen
Autor:
Morgan N Cash, James M. Luther, Adina F. Turcu, Chia Jen Liu, Thomas J. Giordano, Jessie Hoxie, Kazutaka Nanba, Lan L. Gellert, Aaron M. Udager, William E. Rainey, Tobias Else, Juilee Rege
Publikováno v:
J Clin Endocrinol Metab
ContextSomatic gene mutations have been identified in only about half of cortisol-producing adenomas (CPAs). Affected genes include PRKACA, GNAS, PRKAR1A, and CTNNB1.ObjectiveThis work aims to expand our understanding of the prevalence of somatic mut
Autor:
Torfinn Støve Madssen, Tone S. Løvvik, Anders Hagen Jarmund, Live Marie Tobiesen Stokkeland, Eszter Vanky, Signe Nilssen Stafne, Solhild Stridsklev, Mariell Ryssdal, Ann-Charlotte Iversen, Bjørg Steinkjer, Guro F. Giskeødegård
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with low-grade inflammation and increased incidence of pregnancy complications, but its influence on the maternal immune system in pregnancy is unknown. Longitudinal s
Autor:
Wei-Min Tong, Yamei Niu, Ming Feng, Mengqi Chang, Zihao Wang, Jun Gao, Chengxian Yang, Renzhi Wang, Xinjie Bao
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:136-149
Introduction Pituitary growth hormone-secreting (GH) pituitary adenomas (PAs) cause mass effects and dysregulated hypersecretion of GH. However, somatic mutation burden is low in PAs. While progress has been made in identifying the epigenetic changes
Autor:
Yi-Xin Wang, Yi Ye, Yi Wang, An Pan, Xiong-Fei Pan, Xiaorong Qi, Ping Wu, Gang Liu, Ying Wen, Jiaying Yuan, Da Chen, Liangzhong Li, Yichao Huang, Chun-Xia Yang, Huayan Zeng, Yan Liu, Xue Yang, Fengjiang Sun
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:e804-e814
Context While the associations between thyroid markers and gestational diabetes mellitus (GDM) have been extensively studied, the results are inconclusive and the mechanisms remain unclear. Objective We aimed to investigate the prospective associatio