Zobrazeno 1 - 10
of 719
pro vyhledávání: ''
Autor:
Torfinn Støve Madssen, Tone S. Løvvik, Anders Hagen Jarmund, Live Marie Tobiesen Stokkeland, Eszter Vanky, Signe Nilssen Stafne, Solhild Stridsklev, Mariell Ryssdal, Ann-Charlotte Iversen, Bjørg Steinkjer, Guro F. Giskeødegård
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with low-grade inflammation and increased incidence of pregnancy complications, but its influence on the maternal immune system in pregnancy is unknown. Longitudinal s
Autor:
Meagan Gray, Charles M. Rowland, Michael J. McPhaul, Kenneth Cusi, Dov Shiffman, Romina Lomonaco, Srilaxmi Kalavalapalli, Fernando Bril, Diana Barb
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 106:e4360-e4371
Context Patients with nonalcoholic fatty liver disease (NAFLD) are characterized by insulin resistance and hyperinsulinism. However, insulin resistance measurements have not been shown to be good diagnostic tools to predict NAFLD in prior studies. Ob
Autor:
Adrian Vella, Giuseppe De Nicolao, John G. Jones, Marcello C. Laurenti, James C. Andrews, Robert A. Rizza, Chiara Dalla Man, Aleksey V. Matveyenko, Cristina Barosa, Claudio Cobelli, Kent R. Bailey, Ron T. Varghese
Publikováno v:
J Clin Endocrinol Metab
Objective Pulsatile insulin secretion is impaired in diseases such as type 2 diabetes that are characterized by insulin resistance. This has led to the suggestion that changes in insulin pulsatility directly impair insulin signaling. We sought to exa
Autor:
Ou Wang, Yu Li, He Liu, Jiangfeng Mao, Hui Pan, Siyu Liang, Yuxiu Li, Junling Fu, Ming Li, Yan Qin, Shi Chen, Tao Yuan, Huijuan Zhu
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 106:e1051-e1061
Context Extreme insulin resistance is caused by genetic defects intersecting with the insulin action pathway or by the insulin receptor antibodies. Insulin autoimmune syndrome (IAS) is not considered one of the causes of extreme insulin resistance. O
Autor:
Li Zhao, Xianhui Ruan, Weiyu Zhang, Jingtai Zhi, Ming Gao, Peitao Zhang, Shicheng Guo, Mengran Tian, Xiangqian Zheng, Wei Zhang
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 106:91-107
Context Multiple mechanisms play roles in restricting the ability of T-cells to recognize and eliminate tumor cells. Objective To identify immune escape mechanisms involved in papillary thyroid carcinoma (PTC) to optimize immunotherapy. Setting and D
Autor:
Ariella Weinberg-Shukron, Adi Auerbach, Suleyman Gulsuner, Abdulsalam Abu-Libdeh, Amitay Cohen, David Zangen, Mary Claire King, Rina Hemi, Noa Ofek Shlomai, Ephrat Levy-Lahad
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:3486-3495
Context NKX2-2 is a crucial transcription factor that enables specific β-cell gene expression. Nkx2-2(–/–) mice manifest with severe neonatal diabetes and changes in β-cell progenitor fate into ghrelin-producing cells. In humans, recessive NKX2
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Objective To evaluate the efficacy of insulin sensitizers on menstrual frequency, sex hormone, and metabolic parameters in overweight women with polycystic ovary syndrome (PCOS). Methods We searched multiple databases from inception to September 2019
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:e2320-e2326
Context The clinical spectrum and knowledge of the molecular mechanisms underlying primary aldosteronism (PA), the most frequent form of endocrine hypertension, has evolved over recent years. In accordance with the Endocrine Society guidelines and in
Circulating Follistatin and Activin A and Their Regulation by Insulin in Obesity and Type 2 Diabetes
Autor:
Kurt Højlund, Pauline M. Møller, Lykke Sylow, Rikke Kruse, Jørgen F. P. Wojtaszewski, Birgitte F. Vind, Erik A. Richter
Publikováno v:
Sylow, L, Vind, B F, Kruse, R, Møller, P M, Wojtaszewski, J F P, Richter, E A & Højlund, K 2020, ' Circulating follistatin and activin A and their regulation by insulin in obesity and type 2 diabetes ', Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 5, pp. 1343–1354 . https://doi.org/10.1210/clinem/dgaa090
Background Circulating follistatin (Fst) binds activin A and thereby regulates biological functions such as muscle growth and β-cell survival. However, Fst and activin A’s implication in metabolic regulation is unclear. Objective To investigate ci
Autor:
Ann J. Conway, Christopher Yu, Lloyd J Ridley, Veena Jayadev, Carolyn Fennell, Nandini Shankara-Narayana, Reena Desai, Leo Turner, Sasha Savkovic, Len Kritharides, Maaike Kockx, David J. Handelsman
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:1827-1839
Context Androgen abuse impairs male reproductive and cardiac function, but the rate, extent, and determinants of recovery are not understood. Objective To investigate recovery of male reproductive and cardiac function after ceasing androgen intake in