Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lionel Feigenbaum"'
Autor:
Jeremy A. Daniel, André Nussenzweig, Lionel Feigenbaum, Natalya V. Belkina, Barry P. Sleckman, Zhongsheng You, Tanya T. Paull, Manuela Pellegrini, Baeck Seung Lee, Darius Filsuf, Zhi Guo
Publikováno v:
The Journal of Cell Biology
In contrast to ATM-null mice, mice expressing a kinase-dead ATM variant exhibit embryonic lethality, associated with greater deficiency in homologous recombination.
Ataxia telangiectasia (A-T) mutated (ATM) is a key deoxyribonucleic acid (DNA) d
Ataxia telangiectasia (A-T) mutated (ATM) is a key deoxyribonucleic acid (DNA) d
Autor:
Jeremy A. Daniel, Lionel Feigenbaum, Ji-Hoon Lee, Tanya T. Paull, André Nussenzweig, Manuela Pellegrini
Publikováno v:
The Journal of Cell Biology
Cellular responses to both physiological and pathological DNA double-strand breaks are initiated through activation of the evolutionarily conserved ataxia telangiectasia mutated (ATM) kinase. Upon DNA damage, an activation mechanism involving autopho
Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein
Publikováno v:
The Journal of Cell Biology
Improving the efficiency of PrP translocation into the ER decreases levels of transmembrane bound protein and rescues mice from prion disease.
Protein translocation into the endoplasmic reticulum is mediated by signal sequences that vary widely
Protein translocation into the endoplasmic reticulum is mediated by signal sequences that vary widely
Autor:
Federica Polato, Samuel Bunting, Nancy Wong, Hua-Tang Chen, Marina Kozak, Michael Kruhlak, Colleen Reczek, Wen-hwa Lee, Richard Baer, Thomas Ludwig, Lionel Feigenbaum, Stephen Jackson, Andre Nussenzweig
Publikováno v:
The Journal of Cell Biology. 205:2054OIA99
Autor:
Stephen P. Jackson, Lionel Feigenbaum, Youngsoo Lee, André Nussenzweig, Arkady Celeste, Michael J. Difilippantonio, Peter J. McKinnon, Michael J. Kruhlak, Simone Difilippantonio
Publikováno v:
The Journal of Experimental Medicine
The chromosomal instability syndromes Nijmegen breakage syndrome (NBS) and ataxia telangiectasia (AT) share many overlapping phenotypes, including cancer predisposition, radiation sensitivity, cell-cycle checkpoint defects, immunodeficiency, and gona