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Autor:
Kevin Pruitt, Rachel Babcock
Publikováno v:
The Journal of cell biology. 221(12)
Dishevelled exerts a molecular force that guides cell fate, but how it does so remains enigmatic. In this issue, Kang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202205069) show Dvl2 undergoes liquid–liquid phase separation to stabilize
Autor:
Eric Huang, Elise Marsan
Publikováno v:
The Journal of cell biology. 221(10)
Chhetri and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to t
Publikováno v:
The Journal of cell biology. 221(12)
The mechanistic target of rapamycin complex 1 (mTORC1), a multi-subunit protein kinase complex, interrogates growth factor signaling with cellular nutrient and energy status to control metabolic homeostasis. Activation of mTORC1 promotes biosynthesis
Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis
Autor:
Daniela Schloesser, Laura Lindenthal, Julia Sauer, Kyoung-Jin Chung, Triantafyllos Chavakis, Eva Griesser, Praveen Baskaran, Ulrike Maier-Habelsberger, Katrin Fundel-Clemens, Ines Schlotthauer, Carolin Kirsten Watson, Lee Kim Swee, Frederik Igney, John Edward Park, Markus S. Huber-Lang, Matthew-James Thomas, Karim Christian El Kasmi, Peter J. Murray
Publikováno v:
The Journal of cell biology. 222(2)
Progressive accrual of senescent cells in aging and chronic diseases is associated with detrimental effects in tissue homeostasis. We found that senescent fibroblasts and epithelia were not only refractory to macrophage-mediated engulfment and remova
Autor:
Yvette C. Wong, Soojin Kim, Jasmine Cisneros, Catherine G. Molakal, Pingping Song, Steven J. Lubbe, Dimitri Krainc
Publikováno v:
The Journal of cell biology. 221(10)
Lysosomes are highly dynamic organelles implicated in multiple diseases. Using live super-resolution microscopy, we found that lysosomal tethering events rarely undergo lysosomal fusion, but rather untether over time to reorganize the lysosomal netwo
Autor:
Anup Parchure, Meng Tian, Danièle Stalder, Cierra K. Boyer, Shelby C. Bearrows, Kristen E. Rohli, Jianchao Zhang, Felix Rivera-Molina, Bulat R. Ramazanov, Sushil K. Mahata, Yanzhuang Wang, Samuel B. Stephens, David C. Gershlick, Julia von Blume
Publikováno v:
The Journal of cell biology. 221(12)
Insulin is synthesized by pancreatic β-cells and stored into secretory granules (SGs). SGs fuse with the plasma membrane in response to a stimulus and deliver insulin to the bloodstream. The mechanism of how proinsulin and its processing enzymes are
Publikováno v:
The Journal of cell biology. 221(6)
Logue, Gorman, and Samali highlight a study by Guttman and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202111068) that shows exogenous antigen peptides imported into the ER can activate the ER stress sensor IRE1α, attenuating cross-pr
Publikováno v:
The Journal of cell biology. 221(5)
Programmed cell death-ligand 1 (PD-L1)–mediated T cell inhibition through PD-1 is a key checkpoint frequently exploited by tumors to evade immunity. In this issue, Wang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108083) reveal an une
Autor:
Rebecca Harris, Ming Yang, Christina Schmidt, Chloe Royet, Sarbjit Singh, Amarnath Natarajan, May Morris, Christian Frezza, Heike Laman
Publikováno v:
The Journal of cell biology. 221(7)
Fbxo7 is associated with cancer and Parkinson's disease. Although Fbxo7 recruits substrates for SCF-type ubiquitin ligases, it also promotes Cdk6 activation in a ligase-independent fashion. We discovered PFKP, the gatekeeper of glycolysis, in a scree
Autor:
Paola Bezzi
Publikováno v:
The Journal of cell biology. 221(4)
The study of human reactive astrocytes has been limited by resource availability. In this issue, Cvetkovic et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202107135) develop multicellular organoid systems containing mature astrocytes to study